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Klin Monbl Augenheilkd 2024; 241(02): 154-161
DOI: 10.1055/a-2257-6940
Übersicht

The Epidemiology of Glaucoma – an Age-Related Disease

Article in several languages: deutsch | English
Christian Wolfram 
Augenklinik, Universitätsklinikum Hamburg-Eppendorf, Deutschland
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Abstract

Background Epidemiological studies describe the distribution of glaucoma and its risk factors in the general population.

Material and Methods Epidemiological findings from population-based studies were extrapolated for the situation in Germany, in order to estimate current and future prevalence of glaucoma by using official population statistics for Germany.

Results The prevalence of glaucoma in the adult population above 40 years of age is currently 2.1%, resulting in 980 thousand subjects with glaucoma, plus at least one more million subjects with ocular hypertension (OHT). Two thirds of all glaucoma cases are above 70 years of age. By 2060, the prevalence of glaucoma will increase to 2.8%, due to the aging of the population.

Conclusions Despite a decrease in the population size, glaucoma will become more prevalent in the future.

Fazitbox

Bereits bekannt:

  • Das Lebensalter ist der stärkste Risikofaktor für die Entstehung des Glaukoms.

  • Unterschiede der Glaukomprävalenz bestehen zudem nach ethnischer Zugehörigkeit, dem Geschlecht und der Refraktion.

  • Das Wissen über die Ätiologie, den natürlichen Krankheitsverlauf und die Rolle einzelner Risikofaktoren des Glaukoms ist noch immer rudimentär.

Neu beschrieben:

  • Für Deutschland ergibt sich aktuell eine Zahl von knapp 1 Mio. Glaukomkranken, wovon ⅔ über 70 Jahre alt sind.

  • Mit der demografischen Alterung der Gesellschaft nimmt die Relevanz des Glaukoms als Gesundheitsproblem der Bevölkerung zu. Die Prävalenz in der erwachsenen Bevölkerung ab dem 40. Lebensjahr steigt von aktuell 2,1% auf 2,8% im Jahr 2060.

  • Herausforderungen und Chancen für zukünftige Erkenntnisse aus der Epidemiologie ergeben sich aus einer genauen Analyse der Papillenveränderungen größerer Bevölkerungsgruppen im Zeitverlauf.

Conclusion box

What we already know:

  • Age is the strongest risk factor for the development of glaucoma.

  • Glaucoma prevalence also differs according to ethnicity, gender and refraction.

  • The understanding of etiology, the natural course of the disease and the role of individual risk factors in glaucoma is still rudimentary.

Newly described:

  • The current figure for Germany is just under one million people with glaucoma, two thirds of whom are over 70 years old.

  • With the demographic ageing of society, the relevance of glaucoma as a public health problem is increasing. The prevalence in the adult population over the age of 40 is projected to increase from its current 2.1% to 2.8% in 2060.

  • Challenges and opportunities for future findings from epidemiology arise from a precise analysis of papillary changes in larger population groups over time.

Keywords

glaucoma - epidemiology - prevalence - incidence - Germany


Publication History

Received: 15 November 2023

Accepted: 30 January 2024

Article published online:
27 February 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • Literatur/References

  • 1 Bourne RR, Taylor HR, Flaxman SR. et al. Number of People Blind or Visually Impaired by Glaucoma Worldwide and in World Regions 1990–2010: A Meta-Analysis. PLoS One 2016; 11: e0162229
    CrossrefPubMedGoogle Scholar
  • 2 Statistisches Bundesamt. Lebenserwartung und Sterbetafel. 2023 Im Internet (Stand: 2024-01-10): https://www.destatis.de/DE/Themen/Gesellschaft-Umwelt/Bevoelkerung/Sterbefaelle-Lebenserwartung/Tabellen/_tabellen-innen-lebenserwartung-sterbetafel.html
    PubMedGoogle Scholar
  • 3 European Glaucoma Society (EGS). Terminologie und Leitlinien für das Glaukom. 5. Auflage 2020.
    PubMedGoogle Scholar
  • 4 Deutsche Ophthalmologische Gesellschaft (DOG), Berufsverband der Augenärzte Deutschlands (BVA), AWMF. S2e-Leitlinie: Bewertung von Risikofaktoren für das Auftreten des Offenwinkelglaukoms. 21.01.2020. Accessed January 10, 2024 at: https://register.awmf.org/assets/guidelines/045-015l_S2e_Bewertung_Risikofaktoren_fuer_Auftreten_Offenwinkelglaukom_2020-11_1.pdf
    PubMedGoogle Scholar
  • 5 Deutsche Ophthalmologische Gesellschaft (DOG). Leitlinie 15a: Primäres chronisches Offenwinkelglaukom, Normaldruckglaukom und okuläre Hypertension. 2006
    PubMedGoogle Scholar
  • 6 Statisches Bundesamt. Bevölkerungsstatistik für Deutschland – Stand 31.12.2021. 2022 Accessed January 10, 2024 at: https://www.destatis.de/DE/Themen/Gesellschaft-Umwelt/Bevoelkerung/_inhalt.html
    PubMedGoogle Scholar
  • 7 Statistisches Bundesamt. Bevölkerung Deutschlands bis 2060 – 13. koordinierte Bevölkerungsvorausberechnung. 2015 Accessed January 10, 2024 at: https://www.destatis.de/DE/Themen/Gesellschaft-Umwelt/Bevoelkerung/Bevoelkerungsvorausberechnung/Publikationen/Downloads-Vorausberechnung/bevoelkerung-deutschland-2060-presse-5124204159004.pdf?__blob=publicationFile
    PubMedGoogle Scholar
  • 8 Mirshahi A, Ponto KA, Höhn R. et al. [Ophthalmological aspects of the Gutenberg Health Study (GHS): an interdisciplinary prospective population-based cohort study]. Ophthalmologe 2013; 110: 210-217
    PubMedGoogle Scholar
  • 9 Jagodzinski A, Johansen C, Koch-Gromus U. et al. Rationale and Design of the Hamburg City Health Study. Eur J Epidemiol 2020; 35: 169-181
    CrossrefPubMedGoogle Scholar
  • 10 Klein BE, Klein R, Sponsel WE. et al. Prevalence of glaucoma. The Beaver Dam Eye Study. Ophthalmology 1992; 99: 1499-1504
    CrossrefPubMedGoogle Scholar
  • 11 Kahn HA, Milton RC. Revised Framingham eye study prevalence of glaucoma and diabetic retinopathy. Am J Epidemiol 1980; 111: 769-776
    CrossrefPubMedGoogle Scholar
  • 12 Tielsch JM, Sommer A, Katz J. et al. Racial variations in the prevalence of primary open-angle glaucoma. The Baltimore Eye Survey. JAMA 1991; 266: 369-374
    CrossrefPubMedGoogle Scholar
  • 13 Mitchell P, Smith W, Attebo K. et al. Prevalence of open-angle glaucoma in Australia. The Blue Mountains Eye Study. Ophthalmology 1996; 103: 1661-1669
    CrossrefPubMedGoogle Scholar
  • 14 Leske MC, Connell AM, Schachat AP. et al. The Barbados Eye Study. Prevalence of open angle glaucoma. Arch Ophthalmol 1994; 112: 821-829
    CrossrefPubMedGoogle Scholar
  • 15 Dielemans I, Vingerling JR, Wolfs RC. et al. The prevalence of primary open-angle glaucoma in a population-based study in The Netherlands. The Rotterdam Study. Ophthalmology 1994; 101: 1851-1855
    CrossrefPubMedGoogle Scholar
  • 16 Bonomi L, Marchini G, Marraffa M. et al. Prevalence of glaucoma and intraocular pressure distribution in a defined population. The Egna-Neumarkt Study. Ophthalmology 1998; 105: 209-215
    CrossrefPubMedGoogle Scholar
  • 17 Topouzis F, Wilson MR, Harris A. et al. Prevalence of open-angle glaucoma in Greece: the Thessaloniki Eye Study. Am J Ophthalmol 2007; 144: 511-519
    CrossrefPubMedGoogle Scholar
  • 18 Wolfs RC, Borger PH, Ramrattan RS. et al. Changing views on open-angle glaucoma: definitions and prevalences–The Rotterdam Study. Invest Ophthalmol Vis Sci 2000; 41: 3309-3321
    PubMedGoogle Scholar
  • 19 Foster PJ, Buhrmann R, Quigley HA. et al. The definition and classification of glaucoma in prevalence surveys. Br J Ophthalmol 2002; 86: 238-242
    CrossrefPubMedGoogle Scholar
  • 20 Tham YC, Li X, Wong TY. et al. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology 2014; 121: 2081-2090
    CrossrefPubMedGoogle Scholar
  • 21 Zhang N, Wang J, Li Y. et al. Prevalence of primary open angle glaucoma in the last 20 years: a meta-analysis and systematic review. Sci Rep 2021; 11: 13762
    CrossrefPubMedGoogle Scholar
  • 22 Kapetanakis VV, Chan MP, Foster PJ. et al. Global variations and time trends in the prevalence of primary open angle glaucoma (POAG): a systematic review and meta-analysis. Br J Ophthalmol 2016; 100: 86-93
    CrossrefPubMedGoogle Scholar
  • 23 Wang YX, Yang H, Wei CC. et al. High myopia as risk factor for the 10-year incidence of open-angle glaucoma in the Beijing Eye Study. Br J Ophthalmol 2023; 107: 935-940
    CrossrefPubMedGoogle Scholar
  • 24 Gupta P, Zhao D, Guallar E. et al. Prevalence of Glaucoma in the United States: The 2005–2008 National Health and Nutrition Examination Survey. Invest Ophthalmol Vis Sci 2016; 57: 2905-2913
    CrossrefPubMedGoogle Scholar
  • 25 Allison K, Patel D, Alabi O. Epidemiology of Glaucoma: The Past, Present, and Predictions for the Future. Cureus 2020; 12: e11686
    PubMedGoogle Scholar
  • 26 Baskaran M, Foo RC, Cheng CY. et al. The Prevalence and Types of Glaucoma in an Urban Chinese Population: The Singapore Chinese Eye Study. JAMA Ophthalmol 2015; 133: 874-880
    CrossrefPubMedGoogle Scholar
  • 27 Cheng JW, Cheng SW, Ma XY. et al. The prevalence of primary glaucoma in mainland China: a systematic review and meta-analysis. J Glaucoma 2013; 22: 301-306
    CrossrefPubMedGoogle Scholar
  • 28 He M, Foster PJ, Ge J. et al. Prevalence and clinical characteristics of glaucoma in adult Chinese: a population-based study in Liwan District, Guangzhou. Invest Ophthalmol Vis Sci 2006; 47: 2782-2788
    CrossrefPubMedGoogle Scholar
  • 29 Fujiwara K, Yasuda M, Hata J. et al. Prevalence of Glaucoma and Its Systemic Risk Factors in a General Japanese Population: The Hisayama Study. Transl Vis Sci Technol 2022; 11: 11
    CrossrefPubMedGoogle Scholar
  • 30 Day AC, Baio G, Gazzard G. et al. The prevalence of primary angle closure glaucoma in European derived populations: a systematic review. Br J Ophthalmol 2012; 96: 1162-1167
    CrossrefPubMedGoogle Scholar
  • 31 Qiu M, Wang SY, Singh K. et al. Association between myopia and glaucoma in the United States population. Invest Ophthalmol Vis Sci 2013; 54: 830-835
    CrossrefPubMedGoogle Scholar
  • 32 Xu L, Wang Y, Wang S. et al. High myopia and glaucoma susceptibility the Beijing Eye Study. Ophthalmology 2007; 114: 216-220
    CrossrefPubMedGoogle Scholar
  • 33 Tham YC, Cheng CY. Associations between chronic systemic diseases and primary open angle glaucoma: an epidemiological perspective. Clin Exp Ophthalmol 2017; 45: 24-32
    CrossrefPubMedGoogle Scholar
  • 34 Wandell P, Carlsson AC, Ljunggren G. Systemic diseases and their association with open-angle glaucoma in the population of Stockholm. Int Ophthalmol 2022; 42: 1481-1489
    CrossrefPubMedGoogle Scholar
  • 35 Zhao D, Cho J, Kim MH. et al. The association of blood pressure and primary open-angle glaucoma: a meta-analysis. Am J Ophthalmol 2014; 158: 615-627.e9
    CrossrefPubMedGoogle Scholar
  • 36 Jünemann AG, Huchzermeyer C, Rejdak R. et al. [Dyslipidaemia and glaucoma]. Klin Monbl Augenheilkd 2014; 231: 1203-1214
    PubMedGoogle Scholar
  • 37 Hennis A, Wu SY, Nemesure B. et al. Awareness of incident open-angle glaucoma in a population study: the Barbados Eye Studies. Ophthalmology 2007; 114: 1816-1821
    CrossrefPubMedGoogle Scholar
  • 38 Topouzis F, Coleman AL, Harris A. et al. Factors associated with undiagnosed open-angle glaucoma: the Thessaloniki Eye Study. Am J Ophthalmol 2008; 145: 327-335
    PubMedGoogle Scholar
  • 39 Chua J, Baskaran M, Ong PG. et al. Prevalence, Risk Factors, and Visual Features of Undiagnosed Glaucoma: The Singapore Epidemiology of Eye Diseases Study. JAMA Ophthalmol 2015; 133: 938-946
    CrossrefPubMedGoogle Scholar
  • 40 Shen SY, Wong TY, Foster PJ. et al. The prevalence and types of glaucoma in Malay people: the Singapore Malay eye study. Invest Ophthalmol Vis Sci 2008; 49: 3846-3851
    CrossrefPubMedGoogle Scholar
  • 41 Höhn R, Nickels S, Schuster AK. et al. Prevalence of glaucoma in Germany: results from the Gutenberg Health Study. Graefes Arch Clin Exp Ophthalmol 2018; 256: 1695-1702
    CrossrefPubMedGoogle Scholar
  • 42 Wolfram C, Pfeiffer N. [Glaucoma diseases in Rhineland-Palatine 2010. Epidemiology and utilization of healthcare]. Ophthalmologe 2012; 109: 271-276
    PubMedGoogle Scholar
  • 43 Wolfram C, Vu TPL, Klemm M. et al. [Use of antiglaucomatous drugs in the urban adult population: New Insights into the prevalence of glaucoma from the Hamburg City Health Study]. Ophthalmologie 2023; 120: 1098-1106
    PubMedGoogle Scholar
  • 44 Reitmeir P, Linkohr B, Heier M. et al. Common eye diseases in older adults of southern Germany: results from the KORA-Age study. Age Ageing 2017; 46: 481-486
    PubMedGoogle Scholar
  • 45 Bonomi L, Marchini G, Marraffa M. et al. The relationship between intraocular pressure and glaucoma in a defined population. Data from the Egna-Neumarkt Glaucoma Study. Ophthalmologica 2001; 215: 34-38
    CrossrefPubMedGoogle Scholar
  • 46 Chamard C, Villain M, Bron A. et al. Prevalence of Unknown Ocular Hypertension, Glaucoma Suspects, and Glaucoma in Patients Seen in an Ophthalmology Center in France. Ophthalmic Res 2020; 63: 295-301
    CrossrefPubMedGoogle Scholar
  • 47 Finger RP, Bertram B, Wolfram C. et al. Blindness and visual impairment in Germany: a slight fall in prevalence. Dtsch Arztebl Int 2012; 109: 484-489
    PubMedGoogle Scholar
  • 48 Statistisches Bundesamt. Sozialleistungen – Schwerbehinderte Menschen in Deutschland 2013. 2015 Accessed January 10, 2024 at: https://www.statistischebibliothek.de/mir/servlets/MCRFileNodeServlet/DEHeft_derivate_00015408/5227101139004.pdf
    PubMedGoogle Scholar
  • 49 Burr JM, Mowatt G, Hernández R. et al. The clinical effectiveness and cost-effectiveness of screening for open angle glaucoma: a systematic review and economic evaluation. Health Technol Assess 2007; 11: iii-iv ix–x, 1–190
    CrossrefPubMedGoogle Scholar
  • 50 Quigley HA. 21st century glaucoma care. Eye (Lond) 2019; 33: 254-260
    CrossrefPubMedGoogle Scholar
  • 51 Schuster AK, Wagner FM, Pfeiffer N. et al. Risk factors for open-angle glaucoma and recommendations for glaucoma screening. Ophthalmologe 2021; 118 (Suppl. 2) S145-S152
    CrossrefPubMedGoogle Scholar
  • 52 Topouzis F, Coleman AL, Harris A. et al. Factors associated with undiagnosed open-angle glaucoma: the Thessaloniki Eye Study. Am J Ophthalmol 2008; 145: 327-335
    CrossrefPubMedGoogle Scholar