Visible-Light-Driven Oxidative Chlorination of Alkyl sp³ C–H Bonds with HCl/Air at Room Temperature

Abstract

An aerobic chlorination of alkyl sp³ C–H bonds of functionalized alkanes and simple alkanes has been established successfully under visible light at room temperature. The reaction is performed in the presence of catalytic NaNO₂ using HCl or NaCl/acid as a chlorine source and air as a terminal oxidant under atmospheric pressure. It is suggested that NOCl from NaNO₂/HCl is a crucial species in the catalytic cycle involving an aerobic oxidation and a photochemical radical chlorination.

Key words

alkane - chlorination - air - oxidation - sodium nitrite

Publication History

Received: 16 December 2023

Accepted after revision: 05 February 2024

Accepted Manuscript online:
05 February 2024

Article published online:
26 February 2024

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