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DOI: 10.1055/a-2266-3213
Regioselective C3-Formylation of 2H-Indazoles Using Selectfluor under Microwave-Assisted Conditions
Abstract
An efficient microwave-assisted Selectfluor-mediated regioselective C3-formylation of 2H-indazoles bearing a variety of alkyl and aryl substituents using DMSO as the formylating agent has been developed. This methodology provides access to 3-formyl 2H-indazoles with moderate to excellent yields. These functionalized indazoles are potentially useful as templates for drug discovery. Control experimental results suggest that this formylation probably proceeds through a radical pathway.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2266-3213. Spectral data for the new intermediates are presented.
- Supporting Information
Publikationsverlauf
Eingereicht: 18. August 2023
Angenommen nach Revision: 09. Februar 2024
Accepted Manuscript online:
12. Februar 2024
Artikel online veröffentlicht:
04. März 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)
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