Racial Differences in Bleeding Risk: An Ecological Epidemiological Study Comparing Korea and United Kingdom Subjects

Dong-Seon Kang; Pil-Sung Yang; Daehoon Kim; Eunsun Jang; Hee Tae Yu; Tae-Hoon Kim; Jung Hoon Sung; Hui-Nam Pak; Moon-Hyoung Lee; Gregory Y.H. Lip; Boyoung Joung

doi:10.1055/a-2269-1123

Thrombosis and Haemostasis, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Thromb Haemost 2024; 124(09): 842-851
DOI: 10.1055/a-2269-1123

Cellular Haemostasis and Platelets

Racial Differences in Bleeding Risk: An Ecological Epidemiological Study Comparing Korea and United Kingdom Subjects

Dong-Seon Kang^*

¹Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea

,

Pil-Sung Yang^*

²Division of Cardiology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea

,

Daehoon Kim

¹Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea

,

Eunsun Jang

¹Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea

,

Hee Tae Yu

¹Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea

,

Tae-Hoon Kim

¹Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea

,

Jung Hoon Sung

²Division of Cardiology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea

,

Hui-Nam Pak

¹Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea

,

Moon-Hyoung Lee

¹Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea

,

Gregory Y.H. Lip ^*

³Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom

⁴Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

,

Boyoung Joung^*

¹Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea

› Institutsangaben

Abstract

Background This study aimed to evaluate racial differences in bleeding incidence by conducting an ecological epidemiological study using data from Korea and the United Kingdom.

Methods We included healthy participants from the Korean National Health Insurance Service-Health Screening and the UK Biobank who underwent health examinations between 2006 and 2010 and had no comorbidities or history of medication use. Finally, 112,750 East Asians (50.7% men, mean age 52.6 years) and 210,995 Caucasians (44.7% men, mean age 55.0 years) were analyzed. The primary outcome was composed of intracranial hemorrhage (ICH) and bleeding from the gastrointestinal, respiratory, and genitourinary systems.

Results During the follow-up, primary outcome events occurred in 2,110 East Asians and in 6,515 Caucasians. East Asians had a 38% lower 5-year incidence rate compared with Caucasians (3.88 vs. 6.29 per 1,000 person-years; incidence rate ratio [IRR]: 0.62, 95% confidence interval [CI]: 0.59–0.65). East Asians showed a lower incidence of major bleeding (IRR: 0.86, 95% CI: 0.81–0.91), bleeding from the gastrointestinal (IRR: 0.53, 95% CI: 0.49–0.56), and genitourinary systems (IRR: 0.49, 95% CI: 0.44–0.53) compared with Caucasians. The incidence rates of ICH (IRR: 3.20, 95% CI: 2.67–3.84) and bleeding from the respiratory system (IRR: 1.28, 95% CI: 1.11–1.47) were higher in East Asians. Notably, East Asians consuming alcohol ≥3 times/week showed a higher incidence of the primary outcome than Caucasians (IRR: 1.12, 95% CI: 1.01–1.25).

Conclusion This ecological study revealed significant racial differences in bleeding incidence, influenced by anatomical sites and lifestyle habits, underscoring the need for tailored approaches in bleeding management based on race.

Keywords

racial differences - intracranial hemorrhage - gastrointestinal system

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Referenzen

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