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DOI: 10.1055/a-2271-4113
Nicht invasive Beatmung und High-Flow-Therapie: Lebensretter nicht nur bei COPD
Die nicht invasive Beatmung (NIV) und die nasale High-Flow-Therapie (HFNC) sind aus dem Instrumentarium der Intensiv- und Notfallmedizin nicht mehr wegzudenken. Richtig angewendet, können sie dem Patienten mit respiratorischer Insuffizienz eine Intubation ersparen und seine Prognose entscheidend verbessern.
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Um die Vorteile der nicht invasiven Beatmung (NIV) voll ausschöpfen zu können, ist neben der richtigen Indikationsstellung die individuelle Anpassung des Verfahrens an den Patienten und sein Krankheitsbild entscheidend.
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Essenziell sind die Auswahl und Anpassung des Interfaces sowie die differenzierte Einstellung der Beatmungsparameter.
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Die Beatmung mit High-Flow-Nasenkanüle (HFNC) bietet im hypoxisch bedingten Versagen eine wertvolle Alternative zur NIV; im hyperkapnischen Versagen kann sie die NIV oft sinnvoll ergänzen, z. B. in NIV-Pausen.
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Beide Verfahren erfordern eine engmaschige Überprüfung des Therapieerfolgs.
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Bei Therapieversagen ist eine rechtzeitige Intubation indiziert (s. hierzu auch [Abb. 3]).
Publication History
Article published online:
04 June 2024
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Literatur
- 1 Dalziel J. On sleep and apparatus for promoting artificial respiration. Br Assoc Adv Sci 1838; 1: 127
- 2 Brochard L, Isabel D, Piquet J. et al. Reversal of acute exacerbations of chronic obstructive lung disease by inspiratory assistance with a face mask. N Engl J Med 1990; 323: 1523-1530 DOI: 10.1056/NEJM199011293232204. (PMID: 2122253)
- 3 Macintyre N. Physiologic effects of noninvasive ventilation. Respir Care 2019; 64: 617-628 DOI: 10.4187/respcare.06635. (PMID: 31110031)
- 4 Chadda K, Annane D, Hart N. et al. Cardiac and respiratory effects of continuous positive airway pressure and noninvasive ventilation in acute cardiac pulmonary edema. Crit Care Med 2002; 30: 2457-2461 DOI: 10.1097/00003246-200211000-00009. (PMID: 12441754)
- 5 Masip J, Peacock WF, Price S. et al. Indications and practical approach to non-invasive ventilation in acute heart failure. Eur Heart J 2018; 39: 17-25 DOI: 10.1093/eurheartj/ehx580. (PMID: 29186485)
- 6 Westhoff M, Neumann P, Geiseler J. et al. S2k-Leitlinie Nichtinvasive Beatmung als Therapie der akuten respiratorischen Insuffizienz. AWMF-Registernr. 020–004. Accessed December 15, 2023 at: https://register.awmf.org/de/leitlinien/detail/020–004
- 7 Kluge S, Janssens U, Welte T. S3-Leitlinie Empfehlungen zur Stationären Therapie von Patienten mit COVID-19. Pneumologie 2021; 75: 88-112
- 8 Rochester DF, Braun NMT, Arora NS. Respiratory muscle strength in chronic obstructive pulmonary disease. Am Rev Respir Dis 1979; 119: 151-154 DOI: 10.1164/arrd.1979.119.2P2.151. (PMID: 426343)
- 9 Meyer FJ. Assessment and management of hyperinflation in the intensive care unit. Pneumologe 2017; 14: 11-19
- 10 Osadnik CR, Tee VS, Carson-Chahhoud KV. et al. Non-invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2017; (07) CD004104 DOI: 10.1002/14651858.CD004104.pub4. (PMID: 28702957)
- 11 Stefan MS, Nathanson BH, Higgins TL. et al. Comparative effectiveness of noninvasive and invasive ventilation in critically ill patients with acute exacerbation of chronic obstructive pulmonary disease. Crit Care Med 2015; 43: 1386-1394 DOI: 10.1097/CCM.0000000000000945. (PMID: 25768682)
- 12 Plant PK, Owen JL, Elliott MW. Early use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards: a multicentre randomised controlled trial. Lancet 2000; 355: 1931-1935 DOI: 10.1016/s0140-6736(00)02323-0. (PMID: 10859037)
- 13 Diaz GG, Alcaraz AC, Talavera JCP. et al. Noninvasive positive-pressure ventilation to treat hypercapnic coma secondary to respiratory failure. Chest 2005; 127: 952-960 DOI: 10.1378/chest.127.3.952. (PMID: 15764781)
- 14 Conti G, Antonelli M, Navalesi P. et al. Noninvasive vs. conventional mechanical ventilation in patients with chronic obstructive pulmonary disease after failure of medical treatment in the ward: a randomized trial. Intensive Care Med 2022; 28: 1701-1707 DOI: 10.1007/s00134-002-1478-0. (PMID: 12447511)
- 15 Barbé F, Togores B, Rubí M. et al. Noninvasive ventilatory support does not facilitate recovery from acute respiratory failure in chronic obstructive pulmonary disease. Eur Respir J 1996; 9: 1240-1245 DOI: 10.1183/09031936.96.09061240. (PMID: 8804944)
- 16 Burns KEA, Meade MO, Premji A. et al. Noninvasive positive-pressure ventilation as a weaning strategy for intubated adults with respiratory failure. Cochrane Database Syst Rev 2013; (12) CD004127 DOI: 10.1002/14651858.CD004127.pub3. (PMID: 24323843)
- 17 Nava S, Gregoretti C, Fanfulla F. et al. Noninvasive ventilation to prevent respiratory failure after extubation in high-risk patients. Cirt Care Med 2005; 33: 2465-2470 DOI: 10.1097/01.ccm.0000186416.44752.72. (PMID: 16276167)
- 18 Sharp JT, Griffith JT, Bunelli IL. et al. Ventilatory mechanics in pulmonary edema in man. J Clin Investig 1958; 37: 111-117 DOI: 10.1172/JCI103577. (PMID: 13491718)
- 19 Hauge A, Bo G, Waaler BA. Interrelations between pulmonary liquid volumes and lung compliance. J Appl Physiol 1975; 37: 608-614 DOI: 10.1152/jappl.1975.38.4.608. (PMID: 1141091)
- 20 Lenique F, Habis M, Lofaso F. et al. Ventilatory and hemodynamic effects of continuous positive airway pressure in left heart failure. Am J Respir Crit Care Med 1997; 155: 500-505 DOI: 10.1164/ajrccm.155.2.9032185. (PMID: 9032185)
- 21 Gray A, Goodacre S, Newby DE. et al. Noninvasive ventilation in acute cardiogenic pulmonary edema. N Engl J Med 2008; 359: 142-151 DOI: 10.1056/NEJMoa0707992. (PMID: 18614781)
- 22 Berbenetz N, Wang Y, Brown J. et al. Non-invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary oedema. Cochrane Database Syst Rev 2019; (04) CD005351 DOI: 10.1002/14651858.CD005351.pub4. (PMID: 30950507)
- 23 Cabrini L, Landoni G, Oriani A. et al. Noninvasive ventilation and survival in acute care settings: a comprehensive systematic review and metaanalysis of randomized controlled trials. Crit Care Med 2015; 43: 880-888 DOI: 10.1097/CCM.0000000000000819. (PMID: 25565461)
- 24 Vital FMR, Ladeira MT, Atallah AN. et al. Non-invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary oedema. Cochrane Database Syst Rev 2013; (05) CD005351 DOI: 10.1002/14651858.CD005351.pub3. (PMID: 23728654)
- 25 Mariani J, Macchia A, Belziti C. et al. Noninvasive ventilation in acute cardiogenic pulmonary edema: a meta-analysis of randomized controlled trials. J Card Fail 2011; 17: 850-859 DOI: 10.1016/j.cardfail.2011.05.010. (PMID: 21962424)
- 26 Weng CL, Zhao YT, Liu QH. et al. Meta-analysis: noninvasive ventilation in acute cardiogenic pulmonary edema. Ann Intern Med 2010; 152: 590-600 DOI: 10.7326/0003-4819-152-9-201005040-00009. (PMID: 20439577)
- 27 Potts JM. Noninvasive positive pressure ventilation: effect on mortality in acute cardiogenic pulmonary edema: a pragmatic meta-analysis. Pol Arch Med Wewn 2009; 119: 349-353 (PMID: 19694215)
- 28 Confalonieri M, Potena A, Carbone G. et al. Acute respiratory failure in patients with severe community-acquired pneumonia: a prospective randomized evaluation of noninvasive ventilation. Am J Respir Crit Care Med 1999; 160: 1585-1591 DOI: 10.1164/ajrccm.160.5.9903015. (PMID: 10556125)
- 29 Carrillo A, Gonzales-Diaz G, Ferrer M. et al. Non-invasive ventilation in community-acquired pneumonia and severe acute respiratory failure. Intensive Care Med 2012; 38: 458-466 DOI: 10.1007/s00134-012-2475-6. (PMID: 22318634)
- 30 Stefan MS, Priya A, Pekow PS. et al. The comparative effectiveness of noninvasive and invasive ventilation in patients with pneumonia. J Crit Care 2018; 43: 190-196 DOI: 10.1016/j.jcrc.2017.05.023. (PMID: 28915393)
- 31 Carron M, Freo U, Zorzi M. et al. Predictors of failure of noninvasive ventilation in patients with severe community-acquired pneumonia. J Crit Care 2010; 25: 540.e9-540.e14 DOI: 10.1016/j.jcrc.2010.02.012. (PMID: 20435435)
- 32 Nicolini A, Ferraioli G, Ferrari-Bravo M. et al. Early non-invasive ventilation treatment for respiratory failure due to severe community-acquired pneumonia. Clin Respir J 2016; 10: 98-103 DOI: 10.1111/crj.12184. (PMID: 25043135)
- 33 Murad A, Li PZ, Dial S. et al. The role of noninvasive positive pressure ventilation in community-acquired pneumonia. J Crit Care 2015; 30: 49-54 DOI: 10.1016/j.jcrc.2014.09.021. (PMID: 25449883)
- 34 Estopa R, Marti AT, Kastanos N. et al. Acute respiratory failure in severe hematologic disorders. Crit Care Med 1984; 12: 26-28 DOI: 10.1097/00003246-198401000-00007. (PMID: 6690201)
- 35 Blot F, Guiguet M, Nitenberg G. et al. Prognostic factors for neutropenic patients in an intensive care unit: respective roles of underlying malignancies and acute organ failures. Eur J Cancer 1997; 33: 1031-1037 DOI: 10.1016/s0959-8049(97)00042-7. (PMID: 9376183)
- 36 Dumas G, Chevret S, Lemiale V. et al. Survival in immunocompromised patients ultimately requiring invasive mechanical ventilation: a pooled individual patient data analysis. Am J Respir Crit Care Med 2021; 204: 187-196 DOI: 10.1164/rccm.202009-3575OC. (PMID: 33751920)
- 37 Hilbert G, Gruson D, Vargas F. et al. Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure. N Engl J Med 2001; 344: 481-487 DOI: 10.1056/NEJM200102153440703. (PMID: 11172189)
- 38 Antonelli M, Conti G, Bufi M. et al. Noninvasive ventilation for treatment of acute respiratory failure in patients undergoing solid organ transplantation: a randomized trial. JAMA 2000; 283: 235-241 DOI: 10.1001/jama.283.2.235. (PMID: 10634340)
- 39 Lemiale V, Mokart D, Resche-Rigon M. et al. Effect of noninvasive ventilation vs oxygen therapy on mortality among immunocompromised patients with acute respiratory failure: a randomized clinical trial. JAMA 2015; 314: 1711-1719 DOI: 10.1001/jama.2015.12402. (PMID: 26444879)
- 40 Frat JP, Ragot S, Girault C. et al. Effect of non-invasive oxygenation strategies in immunocompromised patients with severe acute respiratory failure: a post-hoc analysis of a randomised trial. Lancet Respir Med 2016; 4: 646-652 DOI: 10.1016/S2213-2600(16)30093-5. (PMID: 27245914)
- 41 Dumas G, Chevret S, Lemiale V. et al. Oxygenation/non-invasive ventilation strategy and risk for intubation in immunocompromised patients with hypoxemic acute respiratory failure. Oncotarget 2018; 9: 33682-33693 DOI: 10.18632/oncotarget.26069. (PMID: 30263094)
- 42 Rathi NK, Haque SA, Nates R. et al. Noninvasivepositive pressure ventilation vs invasive mechanical ventilation as first-line therapy for acute hypoxemic respiratory failure in cancer patients. J Crit Care 2017; 39: 56-61 DOI: 10.1016/j.jcrc.2017.01.007. (PMID: 28213266)
- 43 Barreto LM, Ravetti CG, Athaide TB. et al. Factors associated with non-invasive mechanical ventilation failure in patients with hematological neoplasia and their association with outcomes. J Intensive Care 2020; 8: 68 DOI: 10.1186/s40560-020-00484-x. (PMID: 32922803)
- 44 Oczenski W. Atmen-Atemhilfen: Atemphysiologie und Beatmungstechnik. Stuttgart: Thieme; 2008
- 45 Principi T, Pantanetti S, Catani F. et al. Noninvasive continuous positive airway pressure delivered by helmet in hematological malignancy patients with hypoxemic acute respiratory failure. Intensive Care Med 2004; 30: 147-150 DOI: 10.1007/s00134-003-2056-9. (PMID: 14593457)
- 46 Conti G, Cavaliere F, Costa R. et al. Noninvasive positive-pressure ventilation with different interfaces in patients with respiratory failure after abdominal surgery: a matched-control study. Respir Care 2007; 52: 1463-1471 (PMID: 17971249)
- 47 Adi O, Via G. Salleh. et al. Randomized clinical trial comparing helmet continuous positive airway pressure (hCPAP) to facemask continuous positive airway pressure (fCPAP) for the treatment of acute respiratory failure in the emergency department. Am J Emerg Med 2021; 49: 385-392 DOI: 10.1016/j.ajem.2021.06.031. (PMID: 34271286)
- 48 Antonelli M, Pennisi MA, Pelosi P. et al. Noninvasive positive pressure ventilation using a helmet in patients with acute exacerbation of chronic obstructive pulmonary disease: a feasibility study. Anesthesiology 2004; 100: 16-24 DOI: 10.1097/00000542-200401000-00007. (PMID: 14695719)
- 49 Navalesi P, Costa R, Ceriana P. et al. Non-invasive ventilation in chronic obstructive pulmonary disease patients: helmet versus facial mask. Int Care Med 2007; 33: 74-81 DOI: 10.1007/s00134-006-0391-3. (PMID: 17039354)
- 50 Pankow W, Podszus T, Gutheil T. et al. Expiratory flow limitation and intrinsic positive end-expiratory pressure in obesity. J Appl Physiol (1985) 1998; 85: 1236-1243 DOI: 10.1152/jappl.1998.85.4.1236. (PMID: 9760311)
- 51 Grieco DL, Munshi L, Piquilloud L. Personalized noninvasive respiratory support for acute hypoxemic respiratory failure. Int Care Med 2023; 49: 840-843 DOI: 10.1007/s00134-023-07048-1.
- 52 Duan J, Yang J, Jiang L. et al. Prediction of noninvasive ventilation failure using the ROX index in patients with de novo acute respiratory failure. Ann Intensive Care 2022; 12: 110 DOI: 10.1186/s13613-022-01085-7. (PMID: 36469159)
- 53 Berg KM, Lang GR, Salciccioli JD. et al. The rapid shallow breathing index as a predictor of failure of noninvasive ventilation for patients with acute respiratory failure. Respir Care 2012; 57: 1548-1554 DOI: 10.4187/respcare.01597. (PMID: 22417884)
- 54 Duan J, Han X, Bai L. Zhou. et al. Assessment of heart rate, acidosis, consciousness, oxygenation, and respiratory rate to predict noninvasive ventilation failure in hypoxemic patients. Int Care Med 2017; 43: 192-199 DOI: 10.1007/s00134-016-4601-3. (PMID: 27812731)
- 55 Grieco DL, Maggiore SM, Roca O. et al. Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS. Int Care Med 2021; 47: 851-866 DOI: 10.1007/s00134-021-06459-2. (PMID: 34232336)
- 56 Lee CC, Mankodi D, Shaharyar S. et al. High flow nasal cannula versus conventional oxygen therapy and non-invasive ventilation in adults with acute hypoxemic respiratory failure: a systematic review. Respir Med 2016; 121: 100-108 DOI: 10.1016/j.rmed.2016.11.004. (PMID: 27888983)
- 57 Mauri T, Turrini C, Eronia N. et al. Physiologic effects of high-flow nasal cannula in acute hypoxemic respiratory failure. Am J Respir Crit Care Med 2017; 195: 1207-1215 DOI: 10.1164/rccm.201605-0916OC. (PMID: 27997805)
- 58 Möller W, Celik G, Feng S. et al. Nasal high flow clears anatomical dead space in upper airway models. J Appl Physiol 2015; 118: 1525-1532 DOI: 10.1152/japplphysiol.00934.2014. (PMID: 25882385)
- 59 Luo J, Lu M, Zhao Z. et al. Positive end-expiratory pressure effect of 3 high-flow nasal cannula devices. Respir Care 2017; 62: 888-895 DOI: 10.4187/respcare.05337. (PMID: 28442633)
- 60 Hardavella G, Karampinis I, Frille A. et al. Oxygen devices and delivery systems. Breathe 2019; 15: 108-116 DOI: 10.1183/20734735.0204-2019. (PMID: 31777573)
- 61 Frat JP, Thille AW, Mercat A. et al. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med 2015; 372: 2185-2196 DOI: 10.1056/NEJMoa1503326. (PMID: 25981908)
- 62 Rochwerg B., Granton D, Wang DX. et al. High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: a systematic review and meta-analysis. Intensive Care Med 2019; 45: 563-572 DOI: 10.1007/s00134-019-05590-5. (PMID: 30888444)
- 63 Lewis SR, Baker PE, Parker R. et al. High-flow nasal cannulae for respiratory support in adult intensive care patients. Cochrane Database Syst Rev 2021; (02) CD010172 DOI: 10.1002/14651858.CD010172.pub3. (PMID: 33661521)
- 64 Simon M, Wachs C, Braune S. et al. High-flow nasal cannula versus bag-valve-mask for preoxygenation before intubation in subjects with hypoxemic respiratory failure. Respir Care 2016; 61: 1160-1167 DOI: 10.4187/respcare.04413. (PMID: 27274092)
- 65 Cortegiani A, Longhini F, Madotto F. et al. High flow nasal therapy versus noninvasive ventilation as initial ventilatory strategy in COPD exacerbation: a multicenter non-inferiority randomized trial. Crit Care 2020; 24: 1-13 DOI: 10.1186/s13054-020-03409-0. (PMID: 33317579)
- 66 Yang PL, Yi JQ, Chen HB. High-flow nasal cannula for acute exacerbation of chronic obstructive pulmonary disease: a systematic review and meta-analysis. Heart Lung 2021; 50: 252-261 DOI: 10.1016/j.hrtlng.2020.12.010. (PMID: 33359930)
- 67 Spoletini G, Mega C, Pisani L. et al. High-flow nasal therapy vs standard oxygen during breaks off noninvasive ventilation for acute respiratory failure: a pilot randomized controlled trial. J Crit Care 2018; 48: 418-425 DOI: 10.1016/j.jcrc.2018.10.004. (PMID: 30321833)
- 68 Rochwerg B, Einav S, Chaudhuri D. et al. The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline. Intensive Care Med 2020; 46: 2226-2237 DOI: 10.1007/s00134-020-06312-y. (PMID: 33201321)
- 69 Hui DS, Chow BK, Lo T. et al. Exhaled air dispersion during high-flow nasal cannula therapy versus CPAP via different masks. Eur Respir J 2019; 53: 1802339 DOI: 10.1183/13993003.02339-2018. (PMID: 30705129)
- 70 Wachs C, Grensemann J, Kluge S. High-Flow-Sauerstofftherapie–Schritt für Schritt. DMW-Deutsche Medizinische Wochenschrift 2020; 145: 693-697
- 71 Roca O, Caralt B, Messika J. et al. An index combining respiratory rate and oxygenation to predict outcome of nasal high-flow therapy. Am J Respir Crit Care Med 2019; 199: 1368-1376 DOI: 10.1164/rccm.201803-0589OC. (PMID: 30576221)