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Synthesis
DOI: 10.1055/a-2290-6540
paper

Iodosulfonylation of [1.1.1]Propellane

Mengke Chen
,
Min Ling
,
Zhiwei Huang
,
Dongping Cheng∗
,
Jing-Hua Li∗
This work was supported by the National Natural Science Foundation of China (22078300).
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Abstract

An efficient disubstituted functionalization of [1.1.1]propellane has been developed. The protocol utilizes sulfonyl hydrazides and N-iodosuccinimide, enabling the introduction of iodine and sulfonyl groups into bicyclo[1.1.1]pentane (BCP) in moderate to excellent yields. It has the advantages of simple operation, mild conditions, and broad substrate scope.

Key words

[1.1.1]propellane - bicyclo[1.1.1]pentane - sulfonyl hydrazides - iodosulfonylation - radical reaction

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/a-2290-6540.
  • Supporting Information


Publication History

Received: 19 December 2023

Accepted after revision: 19 March 2024

Accepted Manuscript online:
19 March 2024

Article published online:
08 April 2024

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