A Facile Procedure for Halodecarboxylation of Hydroxyaromatic Carboxylic Acids

Zhenbei Zhang; Wenhui Sun; Zhishan Cao; Guisheng Zhang; Olha Bakumenko; Feng Xue

doi:10.1055/a-2294-4029

Synlett, Table of Contents

Synlett 2024; 35(18): 2117-2122
DOI: 10.1055/a-2294-4029

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A Facile Procedure for Halodecarboxylation of Hydroxyaromatic Carboxylic Acids

Zhenbei Zhang∗

^aCollege of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang, 453002, P. R. of China

^bSchool of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, P. R. of China

,

Wenhui Sun

^aCollege of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang, 453002, P. R. of China

,

Zhishan Cao

^cCollege of Resources and Environment , Henan Institute of Science and Technology, Xinxiang, 453002, P. R. of China

,

Guisheng Zhang

^bSchool of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, P. R. of China

,

Olha Bakumenko∗

^dDepartment of Plant Protection, Sumy National Agrarian University, Sumy, 40021, Ukraine

,

Feng Xue∗

^aCollege of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang, 453002, P. R. of China

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Abstract

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Abstract

An efficient approach is reported for the direct halodecarboxylation of hydroxyaromatic acids by using a readily available N-halosuccinimide (halo = Cl, Br) as the sole promoter in ethanol at room temperature without any other catalyst or additive. This environmentally friendly route tolerates a wide substrate scope with good to excellent yields under convenient conditions.

Key words

halogenation - decarboxylation - N-chlorosuccinimide - N-bromosuccinimide - hydroxyaromatic acids - trihalophenols

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References

References and Notes

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