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Synthesis 2024; 56(22): 3390-3398
DOI: 10.1055/a-2295-5417
DOI: 10.1055/a-2295-5417
paper
Dual Catalysis
Asymmetric Hydrogenative Coupling of Indoles with Unsaturated Ketones Enabled by Copper/Ruthenium Relay Catalysis
This research was supported by the National Natural Science Foundation of China (22172096), the Fundamental Research Funds for the Central Universities (GK202307002, GK202002003), the Projects for the Academic Leaders and Academic Backbones, Shaanxi Normal University (16QNGG008), the Natural Science Basic Research Program of Shaanxi Province (2021JC-30), and the 111 project (B14041).
Abstract
A relay catalytic system is developed for the asymmetric hydrogenative coupling of indoles with α,β-unsaturated ketones, affording enantioenriched chiral γ-indole alcohols with broad substrate scope and excellent enantioselectivities (32 examples, up to >99% ee). Mechanistic studies suggest that the relay catalytic system consists of copper-catalyzed alkylation and ruthenium-catalyzed asymmetric hydrogenation.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2295-5417.
- Supporting Information
Publikationsverlauf
Eingereicht: 01. März 2024
Angenommen nach Revision: 26. März 2024
Accepted Manuscript online:
26. März 2024
Artikel online veröffentlicht:
03. April 2024
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