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DOI: 10.1055/a-2299-0130
Baseline Platelet Count Predicts Infarct Size and Mortality after Acute Myocardial Infarction
Funding H.B.S. has received funding from the European Research Council under the European Union's Horizon 2020 Research and Innovation Programme (STRATO, grant agreement no. 759272), the “Else-Kröner-Fresenius-Stiftung” (2020_EKSE.07), and the “Deutsche Forschungsgemeinschaft (DFG)” (515567441, 470462396, CRC 1123 (B11)). H.B.S. received lecture fees and travel support from Novo Nordisk Pharma GmbH, AstraZeneca GmbH, and Abbott Medical GmbH. S.K. reports speaker and consulting fees from Bristol Myers Squibb and Bentley and speaker fees from AstraZeneca and Translumina not related to the current work.
Abstract
Introduction Platelets greatly contribute to cardiovascular diseases. We sought to explore the association of platelet counts with infarct size and outcome in patients presenting with acute ST-segment elevation MI (STEMI) treated with primary percutaneous coronary intervention (PPCI).
Methods and Results In this retrospective study, we grouped 1,198 STEMI patients into tertiles (T) based on platelet count on admission: T1 = 102–206 [109 platelets/L] (n = 402), T2 = 207–259 [109 platelets/L] (n = 396), and T3 = 260–921 [109 platelets/L] (n = 400). Primary endpoint was 1-year all-cause mortality. Patients with highest platelet counts on admission showed the greatest area at risk and infarct size: area at risk (median) was 22.0% (interquartile range [IQR]: 12.0–39.8%) in T1, 21.0% (IQR: 11.0–37.1%) in T2, and 26.0% (IQR: 14.9–45.0%) of the left ventricle in T3 (p = 0.003); final infarct sizes after 7 to 14 days were as follows: 10.0% (IQR: 2.0–21.0%) in T1, 9.0% (IQR: 2.0–20.7%) in T2, and 12.0% (IQR: 3.0–27.3%) of the left ventricle in T3 (p = 0.015) as serial imaging revealed. At 1 year, 16 all-cause deaths occurred in T1, 5 in T2, and 22 in T3 (log-rank test, p = 0.006). After adjustment, T1 and T3 were associated with all-cause 1-year mortality (T1: hazard ratio [HR] = 3.40, 95% confidence interval [CI] = 1.23–9.54, p = 0.02; T3: HR = 3.55, 95% CI = 1.23–9.78, p = 0.01) compared with T2. At 5 years, all-cause mortality remained numerically higher in the T1 and T3.
Conclusions In patients with STEMI undergoing PPCI, low and high blood platelet levels on admission were associated with increased long-term mortality ([Fig. 1]).
* These authors contributed equally.
Publication History
Received: 09 January 2024
Accepted: 01 April 2024
Article published online:
04 October 2024
© 2024. Thieme. All rights reserved.
Georg Thieme Verlag KG
Stuttgart · New York
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