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DOI: 10.1055/a-2306-8759
The Hallmarks of Endometriosis
Markenzeichen von Endometriose
Abstract
A heuristic tool called “the hallmarks of cancer” helps to reduce the enormous complexity of cancer phenotypes and genotypes to a preliminary set of guiding principles. Other aspects of cancer have surfaced as possible improvements in our understanding of the disease’s mechanisms. Endometriosis is a gynecological disease condition negatively impacting the quality of life of many women. To date, there is no curative treatment for endometriosis. Therapy is aimed at treating the symptoms using hormone therapy, pain therapy and complementary therapy. Chronic pain and overlapping pain syndromes and illnesses can also be treated with multimodal pain therapy and psychosomatic therapy. Endometriosis is, however, a chronic and complex entity which, in this regard, resembles cancer. The present work investigates the hallmarks of endometriosis with a view to summarizing the current research status and paving new ways for future research projects.
Zusammenfassung
Ein heuristisches Werkzeug, „Markenzeichen von Krebs“ genannt, wird eingesetzt, um die große Komplexität der Phänotypen und Genotypen von Krebszellen zu vereinfachen und in einer vorläufigen Reihe von Leitprinzipien zusammenzufassen. Andere Aspekte von Krebserkrankungen sind in jüngster Zeit auch als potenzielle Ansätze zur Verbesserung des Verständnisses von Krebserkrankungsmechanismen in Erscheinung getretten. Die Endometriose ist eine gynäkologische Erkrankung, welche die Lebensqualität vieler Frauen stark beeinträchtigt. Es gibt bisher keine kurative Behandlung dafür. Die aktuellen Therapien fokussieren darauf, Symptome anhand von Hormontherapie, Schmerztherapie sowie komplementären Therapien zu lindern. Chronische Schmerzen und überlappende Schmerzsyndrome und Erkrankungen können mithilfe multimodaler Schmerztherapien und psychosomatischer Therapien behandelt werden. Aber die Endometriose ist eine chronische und komplexe Entität, die Ähnlichkeiten mit Krebs aufweist. Diese Arbeit untersucht die Kennzeichen von Endometriose mit dem Ziel, den aktuellen Forschungsstand zusammenzufassen und neue Wege für künftige Forschungsprojekte zu ebnen.
Publication History
Received: 27 February 2024
Accepted after revision: 14 April 2024
Article published online:
13 June 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Georg Thieme Verlag KG
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References
- 1 Mechsner S. Endometrioseschmerz beherrschen. Schmerz 2021; 35: 159-171
- 2 Burghaus S, Beckmann MW. Endometriose – gynäkologische Diagnostik und Therapie. Schmerz 2021; 35: 172-178
- 3 D’Alterio MN, D’Ancona G, Raslan M. et al. Management Challenges of Deep Infiltrating Endometriosis. Int J Fertil Steril 2021; 15: 88-94
- 4 Schliep KC, Chen Z, Stanford JB. et al. Endometriosis diagnosis and staging by operating surgeon and expert review using multiple diagnostic tools: an inter-rater agreement study. BJOG 2017; 124: 220-229
- 5 Keckstein J, Saridogan E, Ulrich UA. et al. The #Enzian classification: A comprehensive non-invasive and surgical description system for endometriosis. Acta Obstet Gynecol Scand 2021; 100: 1165-1175
- 6 Chapron C, Marcellin L, Borghese B. et al. Rethinking mechanisms, diagnosis and management of endometriosis. Nat Rev Endocrinol 2019; 15: 666-682
- 7 Agarwal SK, Chapron C, Giudice LC. et al. Clinical diagnosis of endometriosis: a call to action. Am J Obstet Gynecol 2019; 220: 354.e1-354.e12
- 8 Strehl JD, Hackl J, Wachter DL. et al. Correlation of histological and macroscopic findings in peritoneal endometriosis. Int J Clin Exp Pathol 2013; 7: 152-162
- 9 Hudelist G, Tuttlies F, Rauter G. et al. Can transvaginal sonography predict infiltration depth in patients with deep infiltrating endometriosis of the rectum?. Hum Reprod 2009; 24: 1012-1017
- 10 Antero MF, Ayhan A, Segars J. et al. Pathology and Pathogenesis of Adenomyosis. Semin Reprod Med 2020; 38: 108-118
- 11 Kalaitzopoulos DR, Samartzis N, Kolovos GN. et al. Treatment of endometriosis: a review with comparison of 8 guidelines. BMC Womens Health 2021; 21: 397
- 12 Brown J, Crawford TJ, Allen C. et al. Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis. Cochrane Database Syst Rev 2017; (01) CD004753
- 13 Burghaus S, Schäfer SD, Beckmann MW. et al. Diagnosis and Treatment of Endometriosis. Guideline of the DGGG, SGGG and OEGGG (S2k Level, AWMF Registry Number 015/045, August 2020). Geburtshilfe Frauenheilkd 2021; 81: 422-446
- 14 Burghaus S, Klingsiek P, Fasching PA. et al. Risk Factors for Endometriosis in a German Case-Control Study. Geburtshilfe Frauenheilkd 2011; 71: 1073-1079
- 15 Psilopatis I, Vrettou K, Fleckenstein FN. et al. The Impact of Histone Modifications in Endometriosis Highlights New Therapeutic Opportunities. Cells 2023; 12: 1227
- 16 Laganà AS, Garzon S, Götte M. et al. The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights. Int J Mol Sci 2019; 20: 5615
- 17 Zondervan KT, Becker CM, Missmer SA. Endometriosis. N Engl J Med 2020; 382: 1244-1256
- 18 Zhang M, Xu T, Tong D. et al. Research advances in endometriosis-related signaling pathways: A review. Biomed Pharmacother 2023; 164: 114909
- 19 Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674
- 20 McKinnon BD, Kocbek V, Nirgianakis K. et al. Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics. Hum Reprod Update 2016; 22: 382-403
- 21 Hung SW, Zhang R, Tan Z. et al. Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review. Med Res Rev 2021; 41: 2489-2564
- 22 Shi J, Tan X, Feng G. et al. Research advances in drug therapy of endometriosis. Front Pharmacol 2023; 14: 1199010
- 23 Karp BI, Stratton P. Endometriosis-associated chronic pelvic pain. Med 2023; 4: 143-146
- 24 Zhang T, De Carolis C, Man GCW. et al. The link between immunity, autoimmunity and endometriosis: a literature update. Autoimmun Rev 2018; 17: 945-955
- 25 Adewuyi EO, Sapkota Y. International Endogene Consortium Iec, andMe Research Team, International Headache Genetics Consortium Ihgc. et al. Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity. Genes (Basel) 2020; 11: 268
- 26 Rahmioglu N, Mortlock S, Ghiasi M. et al. The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions. Nat Genet 2023; 55: 423-436