Redox-Neutral 1,2-Dicarbofunctionalization of Buta-1,3-diene by Merging Decatungstate and Chromium Catalysis

Abstract

Homoallylic alcohol is a significantly useful intermediate in organic synthesis. Here we establish a three-component Nozaki–Hiyama–Kishi (NHK) type reaction of buta-1,3-diene, aldehydes, and aliphatic C–H partners by merging decatungstate and chromium catalysis, enabling a modular, redox-neutral, and atom-economic strategy to access a diverse range of homoallylic alcohols.

Key words

photocatalysis - C–H activation - chromium catalysis - multicomponent reaction - buta-1,3-diene - homoallylic alcohols

Publication History

Received: 21 March 2024

Accepted after revision: 15 May 2024

Accepted Manuscript online:
15 May 2024

Article published online:
03 June 2024

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