Acute Inflammatory Response to Eccentric Exercise in Young and Master
                    Resistance-trained Athletes

Luciele Guerra Minuzzi; Alexander Ferrauti; Matheus Uba Chupel; Sebastian Hacker; Christopher Weyh; Pedro L. Valenzuela; Alejandro Lucia; Karsten Krüger; Thomas Reichel

doi:10.1055/a-2348-0238

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2024; 45(12): 897-907
DOI: 10.1055/a-2348-0238

Physiology & Biochemistry

Acute Inflammatory Response to Eccentric Exercise in Young and Master Resistance-trained Athletes

Luciele Guerra Minuzzi

¹Exercise and Immunometabolism Research Group, Postgraduate Program in Movement Sciences, Department of Physical Education, UNESP Campus de Presidente Prudente, Presidente Prudente, Brazil

²Faculty of Sport Sciences and Physical Education, Research Center for Sport and Physical Activity, University of Coimbra, Coimbra, Portugal

³Department of Exercise Physiology and Sports Therapy, Institute of Sport Science, Justus Liebig University Giessen, Giessen, Germany

,

Alexander Ferrauti

⁴Faculty of Sport Science, Ruhr University Bochum, Bochum, Germany

,

Matheus Uba Chupel

⁵Biological Sciences Platform - Hurvitz Brain Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada

,

Sebastian Hacker

³Department of Exercise Physiology and Sports Therapy, Institute of Sport Science, Justus Liebig University Giessen, Giessen, Germany

,

Christopher Weyh

³Department of Exercise Physiology and Sports Therapy, Institute of Sport Science, Justus Liebig University Giessen, Giessen, Germany

,

Pedro L. Valenzuela

⁶Department of Systems Biology, Universidad de Alcala de Henares, Madrid, Spain

⁷Physical Activity and Health Research Group (PaHerg), Research Institute of Hospital 12 de Octubre (imas12), Madrid, Spain

,

Alejandro Lucia

⁸Faculty of Sport Sciences, Universidad Europea de Madrid, Madrid, Spain

⁹Research Institute of the Hospital 12 de Octubre ('imas12'), Madrid, Spain

,

Karsten Krüger

³Department of Exercise Physiology and Sports Therapy, Institute of Sport Science, Justus Liebig University Giessen, Giessen, Germany

,

Thomas Reichel

³Department of Exercise Physiology and Sports Therapy, Institute of Sport Science, Justus Liebig University Giessen, Giessen, Germany

› Author Affiliations

Abstract

This study aimed to compare the acute inflammatory response following high-intensity eccentric exercise between resistance-trained young and master athletes with similar performance levels. Resistance-trained young (n=8; 22±2 years) and master (n=8; 52±4 years) male athletes of a similar performance level performed a standardized high-intensity eccentric squat exercise protocol (10 sets of half-squats at 70% of 1-repetition maximum). The serum concentration of 20 biomarkers related to tissue damage, inflammation, remodeling, and repair was measured at baseline, immediately after exercise, and over a 72 h recovery period. Both groups experienced similar muscle damage as evidenced by a comparable increase in creatine kinase activity 24 h after exercise (p<0.001). Interleukin-6 (p=0.009) and growth hormone (p<0.001) increased immediately post-exercise in both groups. Monocyte chemoattractant protein-1 increased immediately post-exercise only in young athletes (p=0.003) and then decreased 24 h later. There were no significant differences for the remaining variables, including cell markers related to neutrophil/macrophage activation or pro/anti-inflammatory cytokines. Resistance-trained young and master athletes, matched for performance level, showed an overall similar inflammatory response to eccentric exercise, possibly reflecting regulatory mechanisms or immunological adaptations to chronic stimulation in master athletes.

Keywords

master athletes - eccentric exercise - inflammatory response - muscle damage

Full Text

References

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