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Zentralbl Chir 2024; 149(S 01): S45-S51
DOI: 10.1055/a-2353-0363
Thoraxchirurgie
Übersicht

Zielgerichtete Systemtherapie beim operablen Lungenkarzinom

Perioperative Targeted Therapy for Operable, Early Stage NSCLC
Samer Etman‡
1   Klinik für Thoraxchirurgie, Fachkrankenhaus Coswig GmbH, Coswig, Deutschland (Ringgold ID: RIN549637)
,
Felix Saalfeld‡
2   Department of Oncology, Carl Gustav Carus University Hospital, Dresden, Germany (Ringgold ID: RIN677983)
,
Daniela Aust
3   Department of Pathology, Carl Gustav Carus University Hospital, Dresden, Germany (Ringgold ID: RIN677983)
,
Monika Sombati
1   Klinik für Thoraxchirurgie, Fachkrankenhaus Coswig GmbH, Coswig, Deutschland (Ringgold ID: RIN549637)
,
Rahel Decker
1   Klinik für Thoraxchirurgie, Fachkrankenhaus Coswig GmbH, Coswig, Deutschland (Ringgold ID: RIN549637)
,
Johannes Schweipert
4   Department of Thoracic Surgery, Carl Gustav Carus University Hospital, Dresden, Germany (Ringgold ID: RIN39063)
,
Daniel Baum
1   Klinik für Thoraxchirurgie, Fachkrankenhaus Coswig GmbH, Coswig, Deutschland (Ringgold ID: RIN549637)
,
Martin Wermke
2   Department of Oncology, Carl Gustav Carus University Hospital, Dresden, Germany (Ringgold ID: RIN677983)
,
Till Ploenes
4   Department of Thoracic Surgery, Carl Gustav Carus University Hospital, Dresden, Germany (Ringgold ID: RIN39063)
1   Klinik für Thoraxchirurgie, Fachkrankenhaus Coswig GmbH, Coswig, Deutschland (Ringgold ID: RIN549637)
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Zusammenfassung

Das nicht kleinzellige Lungenkarzinom (NSCLC) fällt durch hohe Rezidivraten in den Frühstadien auf. In einer deutschen Kohorte lag das rezidivfreie Überleben nach 5 Jahren bei 62% (Stadium IA1), 40,7% (Stadium IIA) und 28% (Stadium IIIA). Neben dem perioperativen Einsatz von Immuncheckpointinhibitoren drängt auch die zielgerichtete Tumortherapie als Innovation aus dem palliativen Setting in die frühen Stadien. Von besonderer Relevanz ist der Einsatz des EGFR-Inhibitors Osimertinib (EGFR: Epidermal Growth Factor Receptor), für den eine Verbesserung des Gesamtüberlebens in der adjuvanten Situation gezeigt wurde. In dieser praxisorientierten Übersichtarbeit beschreiben wir kurz den aktuellen Stand der adjuvanten zielgerichteten Therapie und der dazugehörigen Testung und geben einen Ausblick auf weitere Entwicklungen.

Abstract

Non-small cell lung cancer (NSCLC) is characterized by high recurrence rates in the early stages. In a German cohort, recurrence-free survival after 5 years was 62% (stage IA1), 40.7% (stage IIA) and 28% (stage IIIA). In addition to the perioperative use of immune checkpoint inhibitors, targeted tumor therapy is also making inroads as an innovation from the palliative setting into the early stages. Of particular relevance is the use of the EGFR inhibitor osimertinib, which has been shown to improve overall survival in the adjuvant setting. In this practice-oriented review, we briefly describe the current status of adjuvant targeted therapy and the associated testing and provide an outlook on further developments.

Schlüsselwörter

NSCLC - Lungenkarzinom - multimodal - Osimertininb - ADAURA - FLAURA

Keywords

NSCLC - ADAURA - Osimertininb - FLAURA


Publication History

Received: 06 May 2024

Accepted after revision: 25 June 2024

Article published online:
13 August 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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