Subscribe to RSS
DOI: 10.1055/a-2358-6044
Management postoperativer Infektionen nach thoraxchirurgischen Eingriffen

Nosokomiale Infektionen des Operationsgebietes und des operativen Zugangsweges („surgical site infections“, SSI) sind in der postoperativen Phase nach thoraxchirurgischen Eingriffen, trotz der zunehmenden Verbreitung minimalinvasiver und atraumatischer Operationsverfahren, weiter ein relevantes klinisches Problem. Sie können abhängig von Lokalisation und Ausdehnung mit einer hohen Morbidität und Mortalität einhergehen.
-
Postoperative Infektionen nach thoraxchirurgischen Eingriffen bedingen eine hohe Morbidität und Mortalität.
-
Bekannte personen- und prozedurengebundene Risikofaktoren müssen im gesamten perioperativen Verlauf konsequent adressiert werden, um eine Risikominimierung zu erreichen.
-
Für eine intraoperative Antibiotikaprophylaxe besteht bei thoraxchirurgischen Eingriffen eine klare Evidenz.
-
Oberflächliche Wundinfektionen im operativen Zugangsweg werden stadienadaptiert zunächst lokal behandelt, eine Antibiotikatherapie ist nur bei systemischen Infektzeichen oder Auftreten einer phlegmonösen Entzündung indiziert.
-
Bei Auftreten von schweren Komplikationen wie Bronchusstumpfinsuffizienz oder postoperativem Pleuraempyem ist eine rasche, ebenfalls stadienadaptierte Therapie unabdinglich, die bis hin zur Anlage eines Thorakostomas oder einer Thorakoplastik führen kann.
Schlüsselwörter
Infektiologie - Thoraxchirurgie - Bronchusstumpfinsuffizienz - AnastomoseninsuffizienzPublication History
Article published online:
05 March 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
-
Literatur
- 1 Nan DN, Fernández-Ayala M, Fariñas-Alvarez C. et al. Nosocomial infection after lung surgery: incidence and risk factors. Chest 2005; 128: 2647-2652
- 2 Dubiel G, Rogozinski P, Zaloudik E. et al. Identifying the infection control areas requiring modifications in thoracic surgery units: results of a two-year surveillance of Surgical site infections in hospitals in southern poland. Surg Infect 2017; 18: 820-826
- 3 Armbrecht A, Gröschel A, Pöttgen C. et al. Nachsorge, Komplikationen und deren Therapie bei der operativen, strahlentherapeutischen und medikamentösen Therapie des Lungenkarzinoms. Onkologie 2011; 34 (Suppl. 4) 11-16
- 4 Farkas EA, Detterbeck FC. Airway complications after pulmonary resection. Thorac Surg Clin 2006; 16: 243-251
- 5 Sfyridis PG, Kapetanakis EI, Baltayiannis NE. et al. Bronchial stump buttressing with an intercostal muscle flap in diabetic patients. Ann Thorac Surg 2007; 84: 967-971
- 6 Alloubi I, Jougon J, Delcambre F. et al. Early complications after pneumonectomy: retrospective study of 168 patients. Interact Cardiovasc Thorac Surg 2010; 11: 162-165
- 7 Lemaitre J, Mansour Z, Kochetkova EA. et al. Bronchoplastic lobectomy: do early results depend on the underlying pathology? A comparison between typical carcinoids and primary lung cancer. Eur J Cardiothorac Surg 2006; 30: 168-171
- 8 Davis CP. Chapter 6: Normal Flora. In: Baron S. , Hrsg. Medical Microbiology. 4. Galveston: University of Texas Medical Branch; 1996. Accessed January 21, 2025 at: https://www.ncbi.nlm.nih.gov/books/NBK7617
- 9 Robinson J. Colonization and infection of the respiratory tract: What do we know?. Paediat Child Health 2004; 9: 21-24
- 10 Neumeister B, Geiss HK, Braun R, Kimmig P. , Hrsg. Mikrobiologische Diagnostik: Bakteriologie – Mykologie – Virologie – Parasitologi. Stuttgart: Thieme; 2009
- 11 Charlson ES., Bittinger K, Haas A R. et al. Topographical Continuity of Bacterial Populations in the Healthy Human Respiratory Tract. Am J Respir Crit Care Med 2011; 184: 957-963
- 12 Charlson ES, Bittinger K, Chen J. et al. Assessing Bacterial Populations in the Lung by Replicate Analysis of Samples from the Upper and Lower Respiratory Tracts. PLoS One 2012; 7: e42786
- 13 Chang SH, Krupnick AS. Perioperative antibiotics in thoracic surgery. Thorac Surg Clin 2012; 22: 35-45
- 14 Alfageme I, Muñoz F, Peña N. et al. Empyema of the thorax in adults. Etiology, microbiologic findings, and management. Chest 1993; 103: 839-843
- 15 Ban KA, Minei JP, Laronga C. et al. American College of Surgeons and Surgical Infection Society: Surgical Site Infection Guidelines, 2016 Update. J Am Coll Surg 2017; 224: 59-74
- 16 Kommission für Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut, Berlin. Prävention postoperativer Infektionen im Operationsgebiet: Empfehlung der Kommission für Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut. Bundesgesundheitsbl 2018; 61: 448-473
- 17 Qiu B, Han J, Zhao J. Effect of thoracoscopic and thoracotomy on postoperative wound complications in patients with lung cancer: A meta-analysis. Int Wound J 2023; 20: 4217-4226
- 18 Aeschbacher P, Nguyen T, Dorn P. et al. Surgical site infections are associated with higher blood loss and open access in general thoracic surgery practice. Front Surg 2021; 8: 656249
- 19 Suzuki M, Otsuji M, Baba M. et al. Bronchopleural fistula after lung cancer surgery. Multivariate analysis of risk factors. J Cardiovasc Surg (Torino) 2002; 43: 263-267
- 20 Li SJ, Fan J, Zhou J. et al. Diabetes mellitus and risk of bronchopleural fistula after pulmonary resections: a meta-analysis. Ann Thorac Surg 2016; 102: 328-339
- 21 Li S, Fan J, Zhou J. et al. Residual disease at the bronchial stump is positively associated with the risk of bronchoplerual fistula in patients undergoing lung cancer surgery: a meta-analysis. Interact Cardiovasc Thorac Surg 2016; 22: 327-335
- 22 Li SJ, Zhou XD, Huang J. et al. A systematic review and meta-analysis-does chronic obstructive pulmonary disease predispose to bronchopleural fistula formation in patients undergoing lung cancer surgery?. J Thorac Dis 2016; 8: 1625-1638
- 23 Li H, Zheng X, Gao J. Extensive analysis of risk factors associated with surgical site infections post-cardiothoracic open surgery. Int Wound J 2024; 21: e14842
- 24 Turna A, Kutlu CA, Ozalp T. et al. Antibiotic prophylaxis in elective thoracic surgery: cefuroxime versus cefepime. Thorac Cardiovasc Surg 2003; 51: 84-88
- 25 Berríos-Torres SI, Umscheid CA, Bratzler DW. et al. Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017. JAMA Surg 2017; 152: 784-791
- 26 Di Maio M, Perrone F, Deschamps C. et al. A meta-analysis of the impact of bronchial stump coverage on the risk of bronchopleural fistula after pneumonectomy. Eur J Cardiothorac Surg 2015; 48: 196-200
- 27 Llewellyn-Bennett R, Wotton R, West D. Prophylactic flap coverage and the incidence of bronchopleural fistulae after pneumonectomy. Interact Cardiovasc Thorac Surg 2013; 16: 681-685
- 28 Anderson DJ. Prevention of surgical site infection: beyond scip. AORN J 2014; 99: 315-319
- 29 Batchelor T, Rasburn N, Abdelnour-Berchtold E. et al. Guidelines for enhanced recovery after lung surgery: recommendations of the Enhanced Recovery After lung Surgery (ERAS®) and the European Society of Thoracic Surgeons (ESTS). Eur J Cardiothorac Surg 2019; 55: 91-115
- 30 Lobdell K, Perrault L, Drgastin R. et al. Drainology: Leveraging research in chest-drain management to enhance recovery after cardiothoracic surgery. JTCVS Techniques 2024; 24: 226-240
- 31 Maier S, Körner P, Diedrich S. et al. Definition and management of wound infections. Chirurg 2011; 82: 235-241
- 32 Swartz MN. Clinical practice. Cellulitis. N Engl J Med 2004; 350: 904-912
- 33 Forbes SS, McLean RF. Review article: the anesthesiologist’s role in the prevention of surgical site infections. Can J Anaesth 2013; 60: 176-183
- 34 Schneiter D, Cassina P, Korom S. et al. Accelerated treatment for early and late postpneumonectomy empyema. Ann Thorac Surg 2001; 72: 1668-1672
- 35 Park JS, Eom JS, Choi SH. et al. Use of a serratus anterior musculocutaneous flap for surgical obliteration of a bronchopleural fistula. Interact Cardiovasc Thorac Surg 2015; 20: 569-574
- 36 Andreetti C, D’Andrilli A, Ibrahim M. et al. Effective treatment of post-pneumonectomy bronchopleural fistula by conical fully covered self-expandable stent. Interact Cardiovasc Thorac Surg 2012; 14: 420-423
- 37 Cusumano G, Terminella A, Vasta I. et al. Endoscopic stenting for double bronco-pleural fistula after lobectomy. Asian Cardiovasc Thorac Ann 2015; 23: 995-997
- 38 Cao M, Zhu Q, Wang W. et al. Clinical Application of Fully covered self-expandable metal stents in the treatment of bronchial fistula. Thorac Cardiovasc Surg 2016; 64: 533-539
- 39 Mahajan AK, Khandhar SJ. Bronchoscopic valves for prolonged air leak: current status and technique. J Thorac Dis 2017; 9 (Suppl. 2) S110-S115
- 40 Bylicki O, Vandemoortele T, Orsini B. et al. Incidence and management of anastomotic complications after bronchial resection: a retrospective study. Ann Thorac Surg 2014; 98: 1961-1967
- 41 Zaheer S, Allen MS, Cassivi SD. et al. Postpneumonectomy empyema: results after the Clagett procedure. Ann Thorac Surg 2006; 82: 279-286
- 42 Sziklavari Z, Grosser C, Neu R. et al. Complex pleural empyema can be safely treated with vacuum-assisted closure. J Cardiothorac Surg 2011; 6: 130
- 43 Perentes JY, Abdelnour-Berchtold E, Blatter J. et al. Vacuum-assisted closure device for the management of infected postpneumonectomy chest cavities. J Thorac Cardiovasc Surg 2015; 149: 745-750
- 44 Stüben B, Plitzko G, Reeh M. et al. Intrathoracic vacuum therapy for the therapy of pleural empyema – a systematic review and analysis of the literature. J Thorac Dis 2023; 15: 780-790
- 45 Hysi I, Rousse N, Claret A. et al. Open window thoracostomy and thoracoplasty to manage 90 postpneumonectomy empyemas. Ann Thorac Surg 2011; 92: 1833-1839