Silver-Catalyzed Dearomative [3+2] Spiroannulation of Aryl Oxamic Acids with Alkynes

Abstract

A silver-catalyzed dearomative decarboxylative [3+2] spiroannulation of aryl oxamic acids with alkynes is described. The reaction provides reliable access to a range of azaspiro[4,5]trienones in moderate yields in aqueous media. In addition, the reaction exhibits a broad substrate scope and good functional group compatibility.

Key words

silver-catalyzed - dearomative - [3+2] spiroannulation - oxamic acid - alkyne - azaspiro[4,5]trienone

Publication History

Received: 03 June 2024

Accepted after revision: 03 July 2024

Accepted Manuscript online:
03 July 2024

Article published online:
24 July 2024

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