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DOI: 10.1055/a-2367-6993
review

Hydrazide–hydrazones as potential antitubercular agents: overview of the literature (1999-2023)

SURAJ N. MALI 
1   School of Pharmacy, DY Patil Deemed To Be University, Navi Mumbai, India (Ringgold ID: RIN75138)
,
Anima Pandey
2   Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Ranchi, India (Ringgold ID: RIN28698)
,
Umang Shah
3   Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa, India (Ringgold ID: RIN130172)
,
Rahul Jawarkar
4   Department of Medicinal Chemistry and Drug Discovery, Dr Rajendra Gode College of Pharmacy, Malkapur, India (Ringgold ID: RIN470739)
,
Rakesh Somani
5   School of Pharmacy, DY Patil University Deemed to be University, Navi Mumbai, India (Ringgold ID: RIN75138)
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Hydrazide-hydrazone derivatives are prevalent in numerous bioactive compounds, showcasing a diverse array of biological effects including antibacterial, antitubercular, antifungal, anticancer, anti-inflammatory, anticonvulsant, antiviral, and antiprotozoal properties. Consequently, numerous medicinal chemists undertake the synthesis of various hydrazide-hydrazones, subjecting them to evaluation for their biological activities. Among these, antituberculosis activity stands out as a recurring focus in scientific literature. This paper provides a comprehensive overview of research spanning the last twenty-four years (1999-2023), concentrating on the antituberculosis properties of hydrazide-hydrazone derivatives. The insights presented herein could serve as a valuable roadmap for the development of novel hydrazide-hydrazones with potential antimicrobial efficacy.



Publication History

Received: 10 June 2024

Accepted after revision: 03 July 2024

Accepted Manuscript online:
16 July 2024

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