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CC BY 4.0 · SynOpen 2024; 08(03): 173-184
DOI: 10.1055/a-2367-6993
review

Hydrazide–Hydrazones as Potential Antitubercular Agents: An Overview of the Literature (1999–2023)

Suraj N. Mali  ∗
a   School of Pharmacy, D.Y. Patil University (Deemed to be University), Sector 7, Nerul, Navi Mumbai 400706, India
,
Anima Pandey
b   Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, India
,
Umang Shah
c   Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa, India
,
Rahul D Jawarkar
d   Department of Medicinal Chemistry and Drug Discovery, Dr. Rajendra Gode Institute of Pharmacy, University Mardi Road, Amravati, 444603, India
,
Rakesh Somani
a   School of Pharmacy, D.Y. Patil University (Deemed to be University), Sector 7, Nerul, Navi Mumbai 400706, India
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This article is dedicated to my lovely parents, and my younger brother Sagar Mali, who deep-heartedly supported me to achieve my goals.

Abstract

Hydrazide–hydrazone derivatives are prevalent in numerous bioactive compounds, showcasing a diverse array of biological effects including antibacterial, antitubercular, antifungal, anticancer, anti-inflammatory, anticonvulsant, antiviral, and antiprotozoal properties. Consequently, numerous medicinal chemists have undertaken the synthesis of various hydrazide–hydrazones, subjecting them to evaluation for their biological activities. Among these, antituberculosis activity stands out as a recurring focus in the scientific literature. This paper provides a comprehensive overview of research spanning the last 24 years (1999–2023), concentrating on the antituberculosis properties of hydrazide–hydrazone derivatives. The insights presented herein could serve as a valuable roadmap for the development of novel hydrazide–hydrazones with potential antimicrobial efficacy.

Key words

hydrazide–hydrazone - antituberculosis - recent advances - tuberculosis


Publikationsverlauf

Eingereicht: 10. Juni 2024

Angenommen nach Revision: 03. Juli 2024

Accepted Manuscript online:
16. Juli 2024

Artikel online veröffentlicht:
19. August 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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