Synthesis of Difluoromethyl Chromono[3,2-c]pyrazolines/pyrazoles by [3+2] Cycloaddition Reaction of Difluoroacetohydrazonoyl Bromides with 3-EWG-Chromones

Abstract

A highly convenient and straightforward strategy for the synthesis of difluoromethyl substituted tricyclic fused chromono[3,2-c]pyrazolines/pyrazoles is developed via [3+2]-cycloaddition of difluoroacetohydrazonoyl bromides to chromene derivatives bearing an electron-withdrawing group at the 3-position. The reaction has the advantages of mild conditions, good tolerance of functional groups, and simple operation.

Key words

cycloaddition reaction - chromono[3,2-c]pyrazolines - chromono[3,2-c]pyrazoles - difluoroacetohydrazonoyl bromides - 3-EWG chromones

Publikationsverlauf

Eingereicht: 02. Mai 2024

Angenommen nach Revision: 17. Juli 2024

Accepted Manuscript online:
18. Juli 2024

Artikel online veröffentlicht:
12. August 2024

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