Lifestyle Changes in Aging and their Potential Impact on POAG

Abstract

Primary open angle glaucoma is a primary mitochondrial disease with oxidative stress triggering neuroinflammation, eventually resulting in neurodegeneration. This affects many other areas of the brain in addition to the visual system. Aging also leads to inflammaging – a low-grade chronic inflammatory reaction in mitochondrial dysfunction, so these inflammatory processes overlap in the aging process and intensify pathophysiological processes associated with glaucoma. Actively counteracting these inflammatory events involves optimising treatment for any manifest systemic diseases while maintaining chronobiology and improving the microbiome. Physical and mental activity also provides support. This requires a holistic approach towards optimising neurodegeneration treatment in primary open angle glaucoma in addition to reducing intraocular pressure according personalised patient targets.

Fazit

Bereits bekannt:

• Erhöhtes Alter ist ein Risikofaktor für das POWG.

• Das Älterwerden ist ein sehr komplexer Prozess.

• Bekannte Maßnahmen zur Verlangsamung des Alterns sind eine optimale Therapieeinstellung der vorliegenden Systemerkrankungen sowie physische und mentale Aktivität.

Neu beschrieben:

• Das POWG zählt zu den neurodegenerativen Erkrankungen.

• Das Altern führt zu einer chronischen subklinischen Entzündung (Inflamm-Aging).

• Neue Schwerpunkte zur Verlangsamung des Alterns sind eine Einhaltung von chronobiologischen Abläufen und die Aufrechterhaltung eines gesunden enteralen Mikrobioms.

Conclusion

Already known:

• Increased age is a risk factor for POAG.

• Aging is a highly complex process.

• Familiar measures towards slowing down aging include optimised therapy for manifest systemic diseases as well as physical and mental activity.

New:

• POAG is a neurodegenerative disease.

• Aging leads to chronic subclinical inflammation, known as inflammaging.

• New areas of focus for slowing down aging include maintaining chronobiological processes and maintaining a healthy enteral microbiome.

Keywords

Glaucoma - aging - neurodegeneration - chronobiology - microbiome - physical activity

Publication History

Received: 17 December 2023

Accepted: 19 July 2024

Article published online:
27 August 2024

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