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Synthesis
DOI: 10.1055/a-2378-8663
DOI: 10.1055/a-2378-8663
paper
Special Topic Dedicated to Prof. H. Ila
Photoredox-Catalyzed Synthesis of N-Aryl γ-Lactams via Radical Addition–Cyclization Cascade
Generous support by the CSIR [fellowship to AA, TM and 02(0407)/21/EMR-II to SDS] and IISER Kolkata and DST-INSPIRE (for fellowship to VV and infrastructure) is gratefully acknowledged.
Abstract
A visible-light mediated one-pot synthesis of N-aryl γ-lactams is developed following a cascade radical addition/cyclization sequence. This transition metal-free approach proceeds efficiently at room temperature, employing an organic dye as the photocatalyst. Inexpensive N-arylglycines and acrylic acid derivatives were used as the starting materials and a vast array of diversely substituted N-aryl γ-lactams were synthesized in moderate to excellent yields. Detailed mechanistic experiments and comprehensive photophysical studies elucidated a plausible reaction mechanism.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2378-8663.
- Supporting Information
Publication History
Received: 27 June 2024
Accepted after revision: 02 August 2024
Accepted Manuscript online:
02 August 2024
Article published online:
28 August 2024
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