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CC BY-NC-ND 4.0 · Thorac Cardiovasc Surg
DOI: 10.1055/a-2380-6799
Original Thoracic

The Solid Volume Ratio is Better Than the Consolidation Tumor Ratio in Predicting the Malignant Pathological Features of cT1 Lung Adenocarcinoma

Yu Liu   *
1   Department of Thoracic Surgery, PLA 960th Hospital, Jinan, China
,
Ning Jiang   *
2   Department of Thoracic Surgery, The Second Hospital of Shandong University, Jinan, China
,
Zhiqiang Zou
1   Department of Thoracic Surgery, PLA 960th Hospital, Jinan, China
,
Hongxiu Liu
3   Department of Medical Imaging, PLA 960th Hospital, Jinan, China
,
Chuanhang Zang
4   Department of Thoracic Surgery, PLA 964th Hospital, Changchun, China
,
Jia Gu
5   Department of Pathology, PLA 960th Hospital, Jinan, China
,
Ning Xin
1   Department of Thoracic Surgery, PLA 960th Hospital, Jinan, China
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Abstract

Background More effective methods are urgently needed for predicting the pathological grade and lymph node metastasis of cT1-stage lung adenocarcinoma.

Methods We analyzed the relationships between CT quantitative parameters (including three-dimensional parameters) and pathological grade and lymph node metastasis in cT1-stage lung adenocarcinoma patients of our center between January 2015 and December 2023.

Results A total of 343 patients were included, of which there were 233 males and 110 females, aged 61.8 ± 9.4 (30–82) years. The area under the receiver operating characteristic (ROC) curve for predicting the pathological grade of lung adenocarcinoma using the consolidation–tumor ratio (CTR) and the solid volume ratio (SVR) were 0.761 and 0.777, respectively. The areas under the ROC curves (AUCs) for predicting lymph node metastasis were 0.804 and 0.873, respectively. Multivariate logistic regression analysis suggested that the SVR was an independent predictor of highly malignant lung adenocarcinoma pathology, while the SVR and pathological grade were independent predictors of lymph node metastasis. The sensitivity of predicting the pathological grading of lung adenocarcinoma based on SVR >5% was 97.2%, with a negative predictive value of 96%. The sensitivity of predicting lymph node metastasis based on SVR >47.1% was 97.3%, and the negative predictive value was 99.5%.

Conclusion The SVR has greater diagnostic value than the CTR in the preoperative prediction of pathologic grade and lymph node metastasis in stage cT1-stage lung adenocarcinoma patients, and the SVR may replace the diameter and CTR as better criteria for guiding surgical implementation.

Keywords

lung adenocarcinoma - predictive factor - lymph node metastasis - pathological grading

Data Availability Statement

All authors had full access to the data in the study and took responsibility for the integrity of the data and the accuracy of the data analysis.


Authors' Contribution

Conceptualization, Y.L., N.X., and N.J. Methodology, Y.L. and N.X. Investigation, J.G. Formal analysis, Y.L. and N.X. Resources, Y.L., H.L., C.Z. Writing—original draft, Y.L. and N.J. Writing—review and editing, N.X. Visualization, Y.L. Supervision, Z.Z.


* These authors contributed equally to this article.




Publication History

Received: 04 May 2024

Accepted: 06 July 2024

Accepted Manuscript online:
06 August 2024

Article published online:
19 September 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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