Concise Asymmetric Synthesis of Deepoxyalchornoic Acid and (12R,13R)-Isoleukotoxin Diol

Rodney Fernandes; Dnyaneshwar A Gorve; Himanshu Papnai

doi:10.1055/a-2382-4650

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Synthesis
DOI: 10.1055/a-2382-4650

paper

Concise Asymmetric Synthesis of Deepoxyalchornoic Acid and (12R,13R)-Isoleukotoxin Diol

Rodney Fernandes

¹Chemistry, Indian Institute of Technology Bombay, Mumbai, India

,

Dnyaneshwar A Gorve

²Chemistry, Indian Institute of Technology Bombay, Mumbai, India

,

Himanshu Papnai

³Chemistry, Indian Institute of Technology Bombay, Mumbai, India

› Author AffiliationsSupported by: Science and Engineering Research Board CRG/2021/000427

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The first asymmetric synthesis and structural confirmation of deepoxyalchornoic acid have been accomplished from commercially available starting materials. Asymmetric dihydroxylation and Wittig olefination has been strategically executed to achieve a concise synthesis of deepoxyalchornoic acid and (12R,13R)-Isoleukotoxin diol from a common intermediate chiral γ-lactone.

Publication History

Received: 09 July 2024

Accepted after revision: 07 August 2024

Accepted Manuscript online:
07 August 2024

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