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CC BY 4.0 · Sustainability & Circularity NOW 2024; 01: a23865537
DOI: 10.1055/a-2386-5537
DOI: 10.1055/a-2386-5537
Original Article
NaIO4/NH2OH-mediated Efficient Synthesis of Phosphoroamidates from Anilines and Triethyl Phosphite
Funding Information Rambabu Dandela thanks DST-SERB for Core research grants (CRG/2023/001402) and (CRG/2022/001855).
Abstract
A simple, efficient, and metal-free method was developed for the synthesis of phosphoroamidates. In essence, a mixture of sodium periodate (NaIO4) and hydroxylamine (NH2OH⸱HCl) was used in stoichiometric amounts to execute the phosphoramidation reaction of aromatic amines and triethyl phosphites at room temperature, in open air. This method offers a practical synthesis route to afford a diverse range of phosphoroamidates via the construction of P − N bonds, with excellent functional group compatibility and good yields under mild conditions.
Keywords
Metal-free - Sodium periodate (NaIO4) - Hydroxylamine (NH2OH⸱HCl) - Available starting substrates - Phosphoroamidates - Room temperatureSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2386-5537.
- Ergänzendes Material
Publikationsverlauf
Eingereicht: 10. Mai 2024
Angenommen nach Revision: 12. August 2024
Accepted Manuscript online:
13. August 2024
Artikel online veröffentlicht:
09. Oktober 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).
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Bibliographical Record
E. V. Venkat Shivaji Ramarao, Savita Gat, Rana Chatterjee, Jayshree Solanke, Vasudevan Dhayalan, Rambabu Dandela. NaIO4/NH2OH-mediated Efficient Synthesis of Phosphoroamidates from Anilines and Triethyl Phosphite. Sustainability & Circularity NOW 2024; 01: a23865537.
DOI: 10.1055/a-2386-5537
E. V. Venkat Shivaji Ramarao, Savita Gat, Rana Chatterjee, Jayshree Solanke, Vasudevan Dhayalan, Rambabu Dandela. NaIO4/NH2OH-mediated Efficient Synthesis of Phosphoroamidates from Anilines and Triethyl Phosphite. Sustainability & Circularity NOW 2024; 01: a23865537.
DOI: 10.1055/a-2386-5537
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