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CC BY-NC-ND 4.0 · AJP Rep 2024; 14(03): e208-e214
DOI: 10.1055/a-2388-3298
Original Article

Predeposit Autologous Blood Donation in Rh(D)-Negative Pregnant Women: A Single-Center Study

Juan Xie  ‡   *
1   Department of Blood Transfusion, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China
,
Yu Ling  ‡   *
2   Department of Blood Transfusion, Nanjing Women and Children's Healthcare Hospital, Women's Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China
,
Xiaoyu Zhou 
1   Department of Blood Transfusion, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China
› Author Affiliations Funding The study was sponsored by the Special Funds for Health Science and Technology Development of Nanjing City (No. YKK20145).
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Abstract

Objective The primary purpose of this study was to assess the practicability of predeposit autologous blood donation (PABD) in the practice of Rh(D)-negative pregnant women.

Materials and Methods A cohort of 405 Rh(D)-negative pregnant women who had a delivery in the comprehensive tertiary hospital in Nanjing was analyzed retrospectively, over 10 years.

Results After PABD, 203 women experienced a slight drop in mean hemoglobin of 5.32 ± 0.5 g/L (PABD-associated anemia was not featured in our study). Thirteen women who received allogeneic blood might benefit from PABD practically.

Conclusion PABD is applicable for Rh(D)-negative pregnant women, as it ensures the availability of the patient's blood in the event of perinatal hemorrhage, thus minimizing the need for transfusion from external sources. Despite the autologous blood reinfusion of low proportion, PABD could still serve as an alternative when allogeneic blood resources are scarce. However, one challenge in the future is to identify candidates who may benefit most from PABD. Also, more attention is needed to raise awareness of patient blood management. Recommended strategies include early screening and treatment of anemia, hemostasis promotion, and blood loss reduction. Replacement of allogeneic transfusion with autotransfusion could be referred to where feasible. We believe that PABD still has a promising potential for application in Rh(D)-negative pregnant women.

Keywords

predeposit autologous blood donation - postpartum hemorrhage - gestational anemia - patient blood management

* Juan Xie and Yu Ling contributed equally to this work.




Publication History

Received: 03 May 2024

Accepted: 04 August 2024

Accepted Manuscript online:
14 August 2024

Article published online:
30 August 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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