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CC BY 4.0 · SynOpen
DOI: 10.1055/a-2407-4709
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A convenient synthesis of CHF2O-containing pyrrolidines and related compounds — Perspective building blocks for drug discovery

Kostiantyn Levchenko 
1   Building Blocks Production, Enamine Ltd, Kyiv, Ukraine (Ringgold ID: RIN376198)
2   Department of Organic Chemistry, Ivan Franko National University of Lviv, Lviv, Ukraine (Ringgold ID: RIN112865)
,
Ivan Virstiuk
1   Building Blocks Production, Enamine Ltd, Kyiv, Ukraine (Ringgold ID: RIN376198)
2   Department of Organic Chemistry, Ivan Franko National University of Lviv, Lviv, Ukraine (Ringgold ID: RIN112865)
,
Daria Menshykova
1   Building Blocks Production, Enamine Ltd, Kyiv, Ukraine (Ringgold ID: RIN376198)
3   Department of Organic Chemistry, National Technical University of Ukraine Igor Sikorsky Kyiv Polytechnic Institute, Kiiv, Ukraine (Ringgold ID: RIN187495)
,
Nazariy Pokhodylo 
2   Department of Organic Chemistry, Ivan Franko National University of Lviv, Lviv, Ukraine (Ringgold ID: RIN112865)
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Fluorine-containing organic molecules, including CHF2O-derivatives, are among the most sought-after in medicinal chemistry. In the current work, a mini-library of 21 compounds with a CHF2O-motif incorporated with azetidine, pyrrolidine (proline), piperidine, 2-azabicyclo[2.2.1]heptane, and 8-azabicyclo[3.2.1]octane cores were synthesized. A multigram scale (10 to 30 g) procedure for synthesizing title compounds from commercially available amino alcohols was studied.



Publication History

Received: 14 July 2024

Accepted after revision: 30 August 2024

Accepted Manuscript online:
04 December 2024

© . The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

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