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Planta Med 2024; 90(13): 992-1004
DOI: 10.1055/a-2409-2999
Biological and Pharmacological Activity
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Erigeron breviscapus: A Promising Medication for Protecting the Optic Nerve in Glaucoma

Yuxin Cheng
1   Eye School, Chengdu University of Traditional Chinese Medicine, Chengdu, China
2   Department of Ophthalmology, Key Laboratory of Sichuan Province Ophthalmopathy Prevention & Cure and Visual Function Protection with TCM, Sichuan Province, Chengdu, China
,
Xuanyi Chen
3   Acupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, China
,
Guangyu Zhu
1   Eye School, Chengdu University of Traditional Chinese Medicine, Chengdu, China
2   Department of Ophthalmology, Key Laboratory of Sichuan Province Ophthalmopathy Prevention & Cure and Visual Function Protection with TCM, Sichuan Province, Chengdu, China
,
Na Li
4   Department of Infectious Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China
,
Yue Sun
1   Eye School, Chengdu University of Traditional Chinese Medicine, Chengdu, China
2   Department of Ophthalmology, Key Laboratory of Sichuan Province Ophthalmopathy Prevention & Cure and Visual Function Protection with TCM, Sichuan Province, Chengdu, China
,
Shichun Luo
1   Eye School, Chengdu University of Traditional Chinese Medicine, Chengdu, China
2   Department of Ophthalmology, Key Laboratory of Sichuan Province Ophthalmopathy Prevention & Cure and Visual Function Protection with TCM, Sichuan Province, Chengdu, China
,
Yujie Liu
1   Eye School, Chengdu University of Traditional Chinese Medicine, Chengdu, China
2   Department of Ophthalmology, Key Laboratory of Sichuan Province Ophthalmopathy Prevention & Cure and Visual Function Protection with TCM, Sichuan Province, Chengdu, China
,
Xuejing Lu
1   Eye School, Chengdu University of Traditional Chinese Medicine, Chengdu, China
2   Department of Ophthalmology, Key Laboratory of Sichuan Province Ophthalmopathy Prevention & Cure and Visual Function Protection with TCM, Sichuan Province, Chengdu, China
› Author AffiliationsThe authors gratefully acknowledge the support from the National Natural Science Foundation of China (Grant No. 82 174 444).
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Abstract

Glaucoma is a common eye condition characterized by the loss of retinal ganglion cells and their axons, optic nerve damage, and visual field defects, which seriously affect a patientʼs quality of life. The pathogenesis of glaucoma is still unclear at present. It presents as damage to retinal ganglion cells, and the main treatment is primarily to reduce intraocular pressure by surgery or taking medication. However, even with well-controlled intraocular pressure, retinal ganglion cells still undergo degeneration, progressive apoptosis, and axonal loss. Therefore, protecting the optic nerve and inhibiting the apoptosis of retinal ganglion cells are the current hot topic for prevention and treatment of glaucoma. Recently, Erigeron breviscapus, originating from Yunnan province in China, has been shown to be a promising herb with neuroprotective effects to treat glaucoma. Therefore, the traditional usage, botanical characteristics, and phytochemical composition of E. breviscapus were explored through a literature review. Furthermore, we have summarized the pharmacological mechanisms of E. breviscapus and its active components in inhibiting the apoptosis of retinal ganglion cells. These research findings can not only provide guidance and recommendations for the protection of retinal ganglion cells but also further explore the potential of E. breviscapus in the treatment of glaucoma.

Keywords

plants - medicinal - Asteraceae - Erigeron breviscapus - glaucoma - retinal ganglion cells - therapeutics


Publication History

Received: 12 February 2024

Accepted after revision: 21 August 2024

Article published online:
20 September 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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