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DOI: 10.1055/a-2423-9269
Strategies for the Total Synthesis of Fucoxanthin from a Commercial Perspective
This work was supported by the Technology Innovation Program (20020268, Establishment of industrialization foundation through the development of high value-added health functional food materials and combination formulations using Tisochrysis lutea and Phaeodactylum tricornutum) funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea) and was funded by Korea Institute of Marine Science & Technology Promotion (KIMST) funded by the Ministry of Oceans and Fisheries (grant no. 20220134).
Abstract
Fucoxanthin, the light-harvesting pigment of various algae, has shown promising biological activity in pre-clinical and clinical models. It has also received marketing approval as a nutraceutical and cosmetic ingredient in the USA and other countries. The commercial synthesis of this natural ingredient assumes significance because of various drawbacks (low yield, patent infringement, longer duration of cultivation, etc.) associated with its extraction and isolation procedures. This review is intended to provide an appraisal of the total syntheses of fucoxanthin reported to date along with a detailed explanation of the commercially viable approach. Finally, we briefly discuss the future of research for the total synthesis of fucoxanthin.
Publication History
Received: 29 June 2024
Accepted after revision: 18 September 2024
Accepted Manuscript online:
27 September 2024
Article published online:
24 October 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)
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