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CC BY-NC-ND 4.0 · Am J Perinatol
DOI: 10.1055/a-2427-9065
Short Communication

Virulence Potential of ESBL-Producing Escherichia coli Isolated during the Perinatal Period

Hong Yin
1   Department of Clinical Microbiology, Linköping University Hospital, Linköping, Sweden
2   Department of Clinical Microbiology, Falu Hospital, Falun, Sweden
,
Vilma Blomberg
3   Department of Women's and Children's Health, Paediatric Inflammation, Metabolism and Child Health Research, Uppsala University, Uppsala, Sweden
,
Liwei Sun
4   Department of Pediatrics, Changchun Children's Hospital, Changchun City, China
,
ChunXia Yin
5   Department of Obstetrics and Gynecology, Changchun City Hospital, Changchun City, China
,
Susanne Sütterlin 
3   Department of Women's and Children's Health, Paediatric Inflammation, Metabolism and Child Health Research, Uppsala University, Uppsala, Sweden
6   Department of Pediatrics, Uppsala University Hospital, Uppsala, Sweden
› Author Affiliations Funding S.S. holds a grant from ALF funds (grant no.: ALF 810901) and the Swedish Research Council (grant no.: 2019–05909). Generation of sequence data was supported by a grant from Afa Insurance, Sweden (grant no.: 150411) and Alf-de-Ruvo Memorial Foundation, Sweden.
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Abstract

Objective The aim of the study was to investigate the virulence factors in Escherichia coli producing extended-spectrum β-lactamase (ESBL) derived from the perinatal fecal colonization flora of mothers and their newborns in a Chinese obstetric ward.

Study Design Rectal swabs were obtained from mothers prenatally and from their newborns postnatally, and analyzed for ESBL-producing Escherichia coli. The isolates were then whole-genome sequenced.

Results Maternal and neonatal colonization by ESBL-producing E. coli in a Chinese obstetric ward was 18% (31/177) and 5% (9/170), respectively. Fecal ESBL-producing isolates exhibited a significantly lower frequency of virulence factors compared with invasive E. coli.

Conclusion Providing balanced information on screening results is essential, along with conducting a risk assessment for antibiotic treatment strategies.

Key Points

  • High ESBL E. coli colonization rates in mothers and neonates perinatally

  • Fecal ESBL-producing E. coli showed fewer virulence traits.

  • ESBL-producing E. coli knowledge may prompt antibiotic overuse.

Keywords

Escherichia coli - fecal carriage - virulence factors - extended-spectrum β-lactamase - ESBL

Supplementary Material



Publication History

Received: 30 August 2024

Accepted: 19 September 2024

Accepted Manuscript online:
01 October 2024

Article published online:
22 October 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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