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DOI: 10.1055/a-2427-9065
Virulence Potential of ESBL-Producing Escherichia coli Isolated during the Perinatal Period
Funding S.S. holds a grant from ALF funds (grant no.: ALF 810901) and the Swedish Research Council (grant no.: 2019–05909). Generation of sequence data was supported by a grant from Afa Insurance, Sweden (grant no.: 150411) and Alf-de-Ruvo Memorial Foundation, Sweden.
Abstract
Objective The aim of the study was to investigate the virulence factors in Escherichia coli producing extended-spectrum β-lactamase (ESBL) derived from the perinatal fecal colonization flora of mothers and their newborns in a Chinese obstetric ward.
Study Design Rectal swabs were obtained from mothers prenatally and from their newborns postnatally, and analyzed for ESBL-producing Escherichia coli. The isolates were then whole-genome sequenced.
Results Maternal and neonatal colonization by ESBL-producing E. coli in a Chinese obstetric ward was 18% (31/177) and 5% (9/170), respectively. Fecal ESBL-producing isolates exhibited a significantly lower frequency of virulence factors compared with invasive E. coli.
Conclusion Providing balanced information on screening results is essential, along with conducting a risk assessment for antibiotic treatment strategies.
Key Points
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High ESBL E. coli colonization rates in mothers and neonates perinatally
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Fecal ESBL-producing E. coli showed fewer virulence traits.
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ESBL-producing E. coli knowledge may prompt antibiotic overuse.
Keywords
Escherichia coli - fecal carriage - virulence factors - extended-spectrum β-lactamase - ESBLPublikationsverlauf
Eingereicht: 30. August 2024
Angenommen: 19. September 2024
Accepted Manuscript online:
01. Oktober 2024
Artikel online veröffentlicht:
22. Oktober 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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