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CC BY-NC-ND 4.0 · Thromb Haemost 2025; 125(05): 508-512
DOI: 10.1055/a-2434-4905
Letter to the Editor

Cardiac Repair after Myocardial Infarction is Controlled by a Complement C5a Receptor 1-Driven Signaling Cascade

Authors

  • Yaw Asare

    1   Institute for Stroke and Dementia Research, Ludwig Maximilian University, University Hospital, Munich, Germany

  • Sakine Simsekyilmaz

    2   Institute for Molecular Cardiovascular Research, RWTH Aachen University Hospital, Aachen, Germany

  • Janine Köhncke

    2   Institute for Molecular Cardiovascular Research, RWTH Aachen University Hospital, Aachen, Germany

  • Gansuvd Shagdarsuren

    3   Department of Nephrology, School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia

  • Mareike Staudt

    2   Institute for Molecular Cardiovascular Research, RWTH Aachen University Hospital, Aachen, Germany

  • Heidi Noels

    2   Institute for Molecular Cardiovascular Research, RWTH Aachen University Hospital, Aachen, Germany

  • Andreas Klos

    4   Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany

  • Johannes C. Fischer

    5   Institute for Transplantation Diagnostics and Cell Therapeutics, University Hospital and Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

  • Jürgen Bernhagen

    1   Institute for Stroke and Dementia Research, Ludwig Maximilian University, University Hospital, Munich, Germany
    6   German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance (MHA), Munich, Germany

  • Alma Zernecke

    7   Institute of Experimental Biomedicine, University Hospital Würzburg, Würzburg, Germany

  • Elisa A. Liehn

    8   Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark
    9   National Heart Center Singapore, Singapore
    10   ”Victor Babes” National Institute for Pathology, Bucharest, Romania

  • Erdenechimeg Shagdarsuren

    5   Institute for Transplantation Diagnostics and Cell Therapeutics, University Hospital and Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

Funding This work was supported by the Deutsche Forschungsgemeinschaft (DFG; CRC 1123 [B3]; and AS 575/1-1) grant to Y.A. J.B. acknowledges support from DFG (CRC 1123 [A3] and LMUexc strategic partnerships with Singapore) as well as from the German Center for Cardiovascular Research (grant: DZHK B 20-004 Extern/81 × 2600258). E.S. received funding from DFG (GU1223/3-1).
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Graphical Abstract

Ethical Approval Statement

All animal experiments were approved by local authorities (Landesamt für Natur, Umwelt und Verbraucherschutz Nordrhein-Westfalen, Germany) and complied with the German animal protection law (AZ: 8.87-50.10.35.09.088).


Data Availability Statement

All data and materials are presented in the main manuscript or supplementary materials and are available on reasonable request.


Authors' Contribution

Y.A. and E.S. designed research with input from E.L; Y.A., S.S., E.L., J.K., G.S., M.S., H.N. performed research, Y.A., E.S., E.L., S.S., A.K., A.Z., J.B. analyzed data; Y.A., and E.S. wrote the paper. All authors reviewed and edited the manuscript.


Supplementary Material



Publication History

Received: 27 June 2024

Accepted: 17 August 2024

Accepted Manuscript online:
04 October 2024

Article published online:
29 October 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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