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J Neurol Surg B Skull Base
DOI: 10.1055/a-2436-4097
Original Article

Optimizing Surgical Outcomes for Skull Base Epidermoid Cysts

Mueez Waqar 
1   Department of Neurosurgery, Northern Care Alliance NHS Foundation Trust, Salford, United Kingdom
,
Alireza Shoakazemi
2   Department of Neurosurgery, Barking, Havering and Redbridge University Trust, London, United Kingdom
,
James Barber
3   Department of Neurosurgery, The Royal London Hospital, London, United Kingdom
,
Omar N. Pathmanaban
1   Department of Neurosurgery, Northern Care Alliance NHS Foundation Trust, Salford, United Kingdom
,
Scott A. Rutherford
1   Department of Neurosurgery, Northern Care Alliance NHS Foundation Trust, Salford, United Kingdom
,
Andrew T. King
1   Department of Neurosurgery, Northern Care Alliance NHS Foundation Trust, Salford, United Kingdom
,
Charlotte Hammerbeck-Ward
4   Department of Neurosurgery, University Hospitals Sussex NHS Foundation Trust, West Sussex, United Kingdom
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Abstract

Introduction Surgery for skull base epidermoid cysts (SBECs) has several inherent risks including aseptic meningitis and cerebrospinal fluid (CSF) malabsorption. Perioperative measures to reduce the likelihood of such complications have not been evaluated, and this study sought to compare outcomes before and after implementation of an institutional perioperative protocol in the management of SBECs.

Methods Review of a prospective database of surgically managed SBECs. Outcomes were compared before (2003–2008) and after (2010–2021) implementation of a perioperative protocol including intraoperative hyper-irrigation, prolonged course of postoperative steroids, and aggressive management of CSF malabsorption.

Results A total of 39 patients were included: 12 before and 27 after implementation of the protocol. The groups were similar with respect to mean age (p = 0.99), gender (p = 0.29), surgical approach—most commonly retrosigmoid (p > 0.99)—and extent of resection—most commonly total or near total (p = 0.64). The post-protocol implementation group had a significantly lower rate of CSF diversion (p = 0.04). The overall rates of hydrocephalus (7 vs. 30%), CSF leak (19 vs. 33%), bacterial meningitis (15 vs. 33%), and mean length of stay (12 vs. 49 days) were lower in the post-implementation group, although differences did not reach statistical significance. Rates of aseptic meningitis and cranial nerve palsies were similar.

Conclusion Our additional perioperative measures resulted in more favorable CSF dynamics with reduced need for CSF diversion and secondary consequences such as wound leaks and infective meningitis.

Keywords

epidermoid cysts - steroids - dexamethasone - irrigation - posterior fossa

Authors' Contributions

Data collection was conducted by M.W., A.S., J.B., and O.N.P. The data analysis involved M.W., A.S., O.N.P., S.A.R., A.T.K., and C.H.-W. The first draft was written by M.W., A.S., J.B., and O.N.P., while the final draft received approval from all authors.




Publication History

Received: 01 March 2024

Accepted: 06 October 2024

Accepted Manuscript online:
08 October 2024

Article published online:
07 November 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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