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Diabetes aktuell 2024; 22(07): 301-305
DOI: 10.1055/a-2437-3844
Schwerpunkt

Schwere Komplikationen bei Lebendimpfungen

Was uns Kinder mit seltenen Immundefekt-erkrankungen über antivirale Immunität lehren
Florian Gothe
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ZUSAMMENFASSUNG

Lebendimpfstoffe erzeugen eine starke, lang-anhaltende Immunität und haben Millionen Menschenleben weltweit gerettet. Sehr selten jedoch können sich angeborene Störungen des Immunsystems nach einer Lebendimpfung manifestieren. Im vorliegenden Beitrag sollen anhand monogenetischer Immundefekte entscheidende Mechanismen der antiviralen Immunität diskutiert werden. Das Verständnis der jeweiligen pathophysiologischen Grundlagen erlaubt Rückschlüsse beispielsweise auf die Impfstoffentwicklung.



Publikationsverlauf

Artikel online veröffentlicht:
20. November 2024

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