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DOI: 10.1055/a-2438-7367
Different molecular imaging methods for localization and diagnosis of a mesenchymal tumor causing osteomalacia.
Verschiedene molekulare Bildgebungsverfahren zur Lokalisierung und Diagnostik eines mesenchymalen Tumors, der Osteomalazie verursacht.
Introduction
Tumor-induced osteomalacia (TIO), also known as oncogenic osteomalacia (OOM), is a rare paraneoplastic syndrome caused by phosphaturic mesenchymal tumors (PMT) [1]. Although several hundred cases have been reported, the overall incidence remains unknown [1]. TIO is characterized by bone and muscle pain, pathologic fractures, weakness, and fatigue [1]. It typically affects adults, but has also been reported in children [1] [2]. The primary phosphatonin associated with TIO is fibroblast growth factor 23 (FGF-23), which leads to decreased tubular phosphate reabsorption, phosphaturia, and inhibited vitamin D activation, resulting in hypophosphatemia, bone demineralization, osteomalacia, and fractures [1]. Other causes of osteomalacia include severe vitamin D deficiency, hypophosphatemic rickets, renal or parathyroid disease, and certain drugs or toxins [1] [2] [3].
Publication History
Received: 09 September 2024
Accepted: 09 October 2024
Article published online:
20 November 2024
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