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Synthesis
DOI: 10.1055/a-2446-8203
DOI: 10.1055/a-2446-8203
short review
SuFEx Chemistry
Applications of Sulfonyl Fluorides in Organic Transformations
Xi’an Science and Technology Project (2022JH-RYFW-0114), Xi’an Science and Technology Project (2023JH-GXRC-0196), Key Research and Development Project of Shaanxi Province (2022ZDLSF07-04).
Abstract
Sulfonyl fluorides, due to their balanced potential reactivity and stability as well as their compatibility with biological systems, have become important synthetic intermediates and building blocks in the fields of organic synthesis, drug discovery, and materials science. Especially after the report of sulfur(VI) fluoride exchange (SuFEx) chemistry by Sharpless and others, research on sulfonyl fluoride compounds and related compounds has increased significantly. This review summarizes application of sulfonyl fluorides in organic synthesis in the period 2014–2024, discussing different types of organic reactions, including C–X bond formation (including C–C, C–N, and C–F bond formation etc.), S–C bond formation, S–N bond formation, S–O bond formation, multicomponent ‘one-pot’ synthesis, and cyclization.
1 Introduction
2 Sulfonyl Fluorides Applied in C–X (C, N, F) Bond Formation
3 Sulfonyl Fluorides Applied in S–C Bond Formation
4 Sulfonyl Fluorides Applied in S–N Bond Formation
5 Sulfonyl Fluorides Applied in S–O Bond Formation
6 Sulfonyl Fluorides Applied in Multicomponent Reactions
7 Sulfonyl Fluorides Applied in Cyclizations
8 Conclusion and Perspective
Key words
sulfonyl fluorides - SuFEx chemistry - C–X bond formation - S–X bond formation - multicomponent reaction - cyclizationPublication History
Received: 31 July 2024
Accepted after revision: 21 October 2024
Accepted Manuscript online:
21 October 2024
Article published online:
10 December 2024
© 2024. Thieme. All rights reserved
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
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