PDF herunterladen
CC BY-NC-ND 4.0 · AJP Rep 2024; 14(04): e270-e273
DOI: 10.1055/a-2447-8662
Case Report

Cardiac Dysfunction Associated with Lacosamide in a Premature Infant with Hypoxic Ischemic Encephalopathy: A Case Report

Trassanee Chatmethakul 
1   Department of Pediatrics, Neonatal-Perinatal Medicine Section, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
2   Division of Neonatology, Department of Pediatrics, University of Iowa, Iowa City, Iowa
,
Amy H. Stanford
2   Division of Neonatology, Department of Pediatrics, University of Iowa, Iowa City, Iowa
,
Danielle R. Rios
2   Division of Neonatology, Department of Pediatrics, University of Iowa, Iowa City, Iowa
,
Adrianne R. Bischoff
2   Division of Neonatology, Department of Pediatrics, University of Iowa, Iowa City, Iowa
,
Theresa Czech
3   Pediatric Neurology Division, Department of Pediatrics, University of Iowa, Iowa City, Iowa
,
Patrick J. McNamara 
2   Division of Neonatology, Department of Pediatrics, University of Iowa, Iowa City, Iowa
4   Department of Internal Medicine, University of Iowa, Iowa City, Iowa
› Institutsangaben
› Weitere Informationen
Auch verfügbar auf
   Lizenzen und Reprints

Abstract

Lacosamide (Vimpat Harris FRC Corporation, 2022 UCB, Inc. Smyrna, GA 30080) is an antiseizure medication, which acts through blockage of voltage-gated neuronal sodium channels. Its recent implementation in the neonatal population has been extrapolated from adult and pediatric data suggesting a favorable safety profile. Of note, preterm infants have unique developmental characteristics that may predispose them to increased risk of adverse reactions. We present a case of a preterm neonate who developed left ventricular dysfunction coinciding with the initiation of lacosamide.

Keywords

cardiac dysfunction - antiseizure medication - preterm infant - lacosamide


Publikationsverlauf

Eingereicht: 20. September 2024

Angenommen: 16. Oktober 2024

Accepted Manuscript online:
23. Oktober 2024

Artikel online veröffentlicht:
26. November 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

  • References

  • 1 Welsh SS, Lin N, Topjian AA, Abend NS. Safety of intravenous lacosamide in critically ill children. Seizure 2017; 52: 76-80
    CrossrefPubMedSuche in Google Scholar
  • 2 Agras PI, Tarcan A, Baskin E, Cengiz N, Gürakan B, Saatci U. Acute renal failure in the neonatal period. Ren Fail 2004; 26 (03) 305-309
    CrossrefPubMedSuche in Google Scholar
  • 3 Aggarwal A, Kumar P, Chowdhary G, Majumdar S, Narang A. Evaluation of renal functions in asphyxiated newborns. J Trop Pediatr 2005; 51 (05) 295-299
    CrossrefPubMedSuche in Google Scholar
  • 4 Go H, Momoi N, Kashiwabara N. et al. Neonatal and maternal serum creatinine levels during the early postnatal period in preterm and term infants. PLoS One 2018; 13 (05) e0196721
    CrossrefPubMedSuche in Google Scholar
  • 5 Starr MC, Flynn JT. Neonatal hypertension: cases, causes, and clinical approach. Pediatr Nephrol 2019; 34 (05) 787-799
    CrossrefPubMedSuche in Google Scholar
  • 6 Kim GH, Byeon JH, Eun BL. Neuroprotective effect of lacosamide on hypoxic-ischemic brain injury in neonatal rats. J Clin Neurol 2017; 13 (02) 138-143
    CrossrefPubMedSuche in Google Scholar
  • 7 Yu S, Li G, Huang CL, Lei M, Wu L. Late sodium current associated cardiac electrophysiological and mechanical dysfunction. Pflugers Arch 2018; 470 (03) 461-469
    CrossrefPubMedSuche in Google Scholar
  • 8 Berei TJ, Lillyblad MP, Almquist AK. Lacosamide-induced recurrent ventricular tachycardia in the acute care setting. J Pharm Pract 2018; 31 (02) 222-226
    CrossrefPubMedSuche in Google Scholar
  • 9 Maadarani O, Bitar Z, Ashkanani A. et al. Cardiac sodium channel blockade due to antiepileptic drug combination. Eur J Case Rep Intern Med 2021; 8 (10) 002839
    PubMedSuche in Google Scholar
  • 10 Doshi AR, Malhotra MG, Balaguru D, Amre D, Erikson C. Effect of intravenous phenobarbital on left ventricular myocardial contractility determined by echocardiography in children. Kans J Med 2019; 12 (02) 40-44
    CrossrefPubMedSuche in Google Scholar
  • 11 Loughnan PM, Greenwald A, Purton WW, Aranda JV, Watters G, Neims AH. Pharmacokinetic observations of phenytoin disposition in the newborn and young infant. Arch Dis Child 1977; 52 (04) 302-309
    CrossrefPubMedSuche in Google Scholar