The Hidden Culprit: Troubles with Enhanced Deglycosylation in Mechanical Circulatory Support

Attila Braun; Elmina Mammadova-Bach

doi:10.1055/a-2448-2989

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2025; 125(04): 337-339
DOI: 10.1055/a-2448-2989

Invited Editorial Focus

The Hidden Culprit: Troubles with Enhanced Deglycosylation in Mechanical Circulatory Support

Attila Braun

¹Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig Maximilian University, Munich, Germany

,

Elmina Mammadova-Bach

¹Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig Maximilian University, Munich, Germany

²Division of Nephrology, Department of Medicine IV, Ludwig Maximilian University Hospital, Munich, Germany

› Author Affiliations

Abstract

Full Text

References

References
1 Roka-Moiia Y, Lewis S, Cleveland E, Italiano JE, Slepian MJ. Shear stress promotes remodeling of platelet glycosylation via upregulation of platelet glycosidase activity: one more thing. Thromb Haemost 2024;
2 Koliopoulou A, McKellar SH, Rondina M, Selzman CH. Bleeding and thrombosis in chronic ventricular assist device therapy: focus on platelets. Curr Opin Cardiol 2016; 31 (03) 299-307
3 Susen S, Rauch A, Van Belle E, Vincentelli A, Lenting PJ. Circulatory support devices: fundamental aspects and clinical management of bleeding and thrombosis. J Thromb Haemost 2015; 13 (10) 1757-1767
4 Mondal NK, Chen Z, Trivedi JR. et al. Oxidative stress induced modulation of platelet integrin α2bβ3 expression and shedding may predict the risk of major bleeding in heart failure patients supported by continuous flow left ventricular assist devices. Thromb Res 2017; 158: 140-148
5 Mammadova-Bach E, Gudermann T, Braun A. Platelet mechanotransduction: regulatory cross talk between mechanosensitive receptors and calcium channels. Arterioscler Thromb Vasc Biol 2023; 43 (08) 1339-1348
6 Foley K, Rao V, Djaiani G. Mechanical circulatory support and heparin: friends or foes?. J Cardiothorac Vasc Anesth 2023; 37 (12) 2508-2510
7 Bain J, Flannery AH, Flynn J, Dager W. Heparin induced thrombocytopenia with mechanical circulatory support devices: review of the literature and management considerations. J Thromb Thrombolysis 2017; 44 (01) 76-87
8 Sugimura Y, Bauer S, Immohr MB. et al. Heparin-induced thrombocytopenia under mechanical circulatory support by large impella for acute cardiogenic shock. J Cardiovasc Dev Dis 2021; 8 (12) 161
9 Teuteberg JJ, Slaughter MS, Rogers JG. et al; ADVANCE Trial Investigators. The HVAD left ventricular assist device: risk factors for neurological events and risk mitigation strategies. JACC Heart Fail 2015; 3 (10) 818-828
10 Lee-Sundlov MM, Stowell SR, Hoffmeister KM. Multifaceted role of glycosylation in transfusion medicine, platelets, and red blood cells. J Thromb Haemost 2020; 18 (07) 1535-1547
11 Choi SI, Simone JV, Jorney LJ. Neuraminidase-induced thrombocytopenia in rats. Br J Haematol 1972; 22 (01) 93-101
12 Li J, van der Wal DE, Zhu G. et al. Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia. Nat Commun 2015; 6: 7737
13 Nurden AT, Nurden P. Inherited thrombocytopenias: history, advances and perspectives. Haematologica 2020; 105 (08) 2004-2019
14 Jansen AJ, Peng J, Zhao HG, Hou M, Ni H. Sialidase inhibition to increase platelet counts: a new treatment option for thrombocytopenia. Am J Hematol 2015; 90 (05) E94-E95
15 Muthiah C, Lian Q, Benz S. et al. An extensive database analysis demonstrates significant increase in platelet quantity in unselected hospitalized patients following treatment with oseltamivir. Haematologica 2024; 109 (06) 1933-1935
16 Roka-Moiia Y, Miller-Gutierrez S, Palomares DE. et al. Platelet dysfunction during mechanical circulatory support: elevated shear stress promotes downregulation of α_IIbβ₃ and GPIb via microparticle shedding decreasing platelet aggregability. Arterioscler Thromb Vasc Biol 2021; 41 (04) 1319-1336
17 Roka-Moiia Y, Ammann KR, Miller-Gutierrez S. et al. Shear-mediated platelet microparticles demonstrate phenotypic heterogeneity as to morphology, receptor distribution, and hemostatic function. Int J Mol Sci 2023; 24 (08) 7386