PDF herunterladen
CC BY 4.0 · Sustainability & Circularity NOW 2024; 01: a24604207
DOI: 10.1055/a-2460-4207
Review

Materials Sustainability in the Pharmaceutical Industry

Ankita Bhadoriya
1   Department of Quality Assurance and Medicinal Chemistry, Indore Institute of Pharmacy, Rau, Indore, Madhya Pradesh 453331, India
,
Bhakti Patil
2   Department of Pharmacy, Shri G.S. Institute of Technology and Science, Indore, Madhya Pradesh 452003, India
,
Kuldeep Vinchurkar 
3   Department of Pharmaceutics and Pharmaceutical Technology, Krishna School of Pharmacy and Research, Drs. Kiran and Pallavi Patel Global University (KPGU), Varnama, Vadodara, Gujarat 391243, India
,
Sheetal Mane
4   School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore, Madhya Pradesh 452003, India
,
Anilkumar Parambath
5   Research and Development Department, YTY Industry – Indorama Corporation, Sitiawan 32000, Perak, Malaysia
› Institutsangaben
› Weitere Informationen
   Lizenzen und Reprints Alle Artikel dieser Rubrik


Abstract

In the pharmaceutical industry, sustainable materials development is increasingly vital. The environmental impacts of medications emerge across their entire life cycle. While the pharmaceutical industry plays a crucial role in minimizing these effects during early production stages, opportunities to reduce environmental impacts stemming from drug consumption and disposal are currently limited. The pharmaceutical industry faces growing pressure to integrate sustainable practices into its operations due to environmental concerns and regulatory requirements. Materials sustainability, focusing on the responsible use of resources and minimizing environmental impact, has emerged as a crucial aspect of this transformation. Key strategies include the adoption of green chemistry principles to reduce hazardous substances and waste generation during drug development and manufacturing processes. Biodegradable materials and eco-friendly packaging designs are increasingly favored to mitigate the industry's impact on landfills and ecosystems. Challenges remain, including the complexity of regulatory frameworks and the need for collaborative efforts across stakeholders to achieve meaningful progress in material sustainability. This review is an attempt to present materials sustainability in the pharmaceutical industry and its pivotal shift toward environmentally responsible practices, driven by innovation, and regulation, aimed to investigate current environmental initiatives within the industry, alongside perspectives and attitudes regarding strategies to tackle environmental challenges and concerns. Sustainability in the pharmaceutical industry requires a holistic and integrated approach, involving every aspect of the business, from supply chain management to product development. By prioritizing sustainability, the industry can contribute to global climate goals while ensuring its own resilience and long-term success.

Keywords

Sustainability - Regulation - Pharmaceuticals in the environment - Pharmaceutical industry - Environmental classification - Green chemistry


Publikationsverlauf

Eingereicht: 02. August 2024

Angenommen nach Revision: 31. Oktober 2024

Accepted Manuscript online:
01. November 2024

Artikel online veröffentlicht:
12. Dezember 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

Bibliographical Record
Ankita Bhadoriya, Bhakti Patil, Kuldeep Vinchurkar, Sheetal Mane, Anilkumar Parambath. Materials Sustainability in the Pharmaceutical Industry. Sustainability & Circularity NOW 2024; 01: a24604207.
DOI: 10.1055/a-2460-4207
 

  • References

  • 1 Environmental management system: The internal and external impact of ISO 14001 implementation on the manufacturing companies. In IOP Conference Series: Earth and Environmental Science. Widiatami A, Pitaloka L, Nurkhin A. Eds IOP Publishing; Bristol (UK): 2022
    Suche in Google Scholar
  • 2 Johnson J, Vincent A. Proposal: Multi-annual (2021-2024) training package to address EFSA’s crisis preparedness needs. EFSA Supporting Publ. 2021; 18 (04) 6567E
    Suche in Google Scholar
  • 3 Freedhoff M. Toxic Substances Control Act (TSCA) Section 21 Petition for Rulemaking under TSCA Section 6; Reasons for Agency Response: Denial of Requested Rulemaking.
  • 4 Responsibility and the United Nations’ sustainable development goals. In Forum for development studies. Bexell M, Jönsson K. Eds Taylor & Francis; 2017
    Suche in Google Scholar
  • 5 Reno J. Waste and waste management. Annu. Rev. Anthropol. 2015; 44: 557-572
    Suche in Google Scholar
  • 6 Corvellec H, Stowell AF, Johansson N. Critiques of the circular economy. J. Ind. Ecol. 2022; 26 (02) 421-432
    Suche in Google Scholar
  • 7 Ly LT, Maggi FM, Montali M, Rinderle-Ma S, Van Der Aalst WM. Compliance monitoring in business processes: Functionalities, application, and tool-support. Inf. Syst. 2015; 54: 209-34
    Suche in Google Scholar
  • 8 Kuhre WL.. ISO 14001 certification. Prentice Hall; Upper Saddle River, NJ: 1995
    Suche in Google Scholar
  • 9 Chaloner-Larsson G, Anderson R, Egan A, Da Fonseca Costa Filho MA, Gomez Herrera JF, Supply V. et al. A WHO guide to good manufacturing practice (GMP) requirements. World Health Organization; 1999
    Suche in Google Scholar
  • 10 He T.-T, Ung CO. L, Hu H, Wang Y.-T. Good manufacturing practice (GMP) regulation of herbal medicine in comparative research: China GMP, cGMP, WHO-GMP, PIC/S and EU-GMP. Eur. J. Integr. Med. 2015; 7 (01) 55-66
    Suche in Google Scholar
  • 11 Shukla J. Good manufacturing practice (GMP): an overview. 2019
    Suche in Google Scholar
  • 12 Ojha A, Bhargava S. International council for harmonisation (ICH) guidelines. In Regulatory affairs in the pharmaceutical industry. Elsevier; 2022. pp 47-74
    Suche in Google Scholar
  • 13 Halkos G, Nomikos S. Corporate social responsibility: Trends in global reporting initiative standards. Econ. Anal. Policy 2021; 69: 106-117
    Suche in Google Scholar
  • 14 Brown H. Global reporting initiative. Handbook of Transnational Governance: Institutions & Innovations. Polity Press; Cambridge, UK: 2011. pp 281-289
    Suche in Google Scholar
  • 15 Hengstler J, Foth H, Kahl R, Kramer P, Lilienblum W, Schulz T. et al. The REACH concept and its impact on toxicological sciences. Toxicology 2006; 220 (2) –3 232-239
    Suche in Google Scholar
  • 16 Ingre-Khans E, Ågerstrand M, Beronius A, Rudén C. Toxicity studies used in registration, evaluation, authorisation and restriction of chemicals (REACH): How accurately are they reported?. Integr. Environ. Assess. Manage. 2019; 15 (03) 458-469
    Suche in Google Scholar
  • 17 Jagadeeswaran I, Sriram H. EU 1907/2006–Registration, Evaluation, Authorisation and Restriction of Chemicals. In Medical Device Guidelines and Regulations Handbook. Springer; 2022. pp 237-260
    Suche in Google Scholar
  • 18 Chatzopoulou S, Eriksson NL, Eriksson D. Improving risk assessment in the European food safety authority: lessons from the European Medicines Agency. Front. Plant Sci. 2020; 11: 488663
    Suche in Google Scholar
  • 19 Nabholz JV. Environmental hazard and risk assessment under the United States toxic substances control act. Sci. Total Environ. 1991; 109: 649-665
    Suche in Google Scholar
  • 20 Rayasam SD, Koman PD, Axelrad DA, Woodruff TJ, Chartres N. Toxic Substances Control Act (TSCA) implementation: how the amended law has failed to protect vulnerable populations from toxic chemicals in the United States. Environ. Sci. Technol. 2022; 56 (17) 11969-11982
    Suche in Google Scholar
  • 21 Vincent P. FDA’s implementation of the National Environmental Policy Act. Fundamentals of Aquatic Toxicology. CRC Press; 2020. pp 735-762
    Suche in Google Scholar
  • 22 Grossman MR, Recent FD. A. Regulatory Measures. Eur. Food Feed Law Rev. 2014; 9: 60
    Suche in Google Scholar
  • 23 Zhang L, He G, Mol AP, Zhu X. Power politics in the revision of China’s Environmental Protection Law. Environ. Polit. 2013; 22 (06) 1029-1035
    Suche in Google Scholar
  • 24 Kubota Y. Experience with the chemical substances control law in Japan. Ecotoxicol. Environ. Saf. 1979; 3 (03) 256-268
    Suche in Google Scholar
  • 25 Hyer A, Gregory D, Kay K, Le Q, Turnage J, Gupton F. et al. Continuous Manufacturing of Active Pharmaceutical Ingredients: Current Trends and Perspectives. Adv. Synth. Catal. 2024; 366 (03) 357-389
    Suche in Google Scholar
  • 26 Karwehl S, Stadler M. Exploitation of fungal biodiversity for discovery of novel antibiotics. How to Overcome the Antibiotic Crisis: Facts, Challenges, Technologies and Future Perspectives. Curr. Top. Microbiol. Immunol. 2016; 398: 303-338
    Suche in Google Scholar
  • 27 Newman DJ, Cragg GM. Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. J. Nat. Prod. 2020; 83 (03) 770-803
    Suche in Google Scholar
  • 28 Jiménez-González C, Constable DJ. Green chemistry and engineering: a practical design approach. John Wiley & Sons; 2011
    Suche in Google Scholar
  • 29 Küster A, Adler N. Pharmaceuticals in the environment: scientific evidence of risks and its regulation. Philos. Trans. R. Soc., B 2014; 369 (1656) 20130587
    Suche in Google Scholar
  • 30 Hopewell J, Dvorak R, Kosior E. Plastics recycling: challenges and opportunities. Philos. Trans. R. Soc., B 2009; 364 (1526) 2115-2126
    Suche in Google Scholar
  • 31 Bridson JH, Gaugler EC, Smith DA, Northcott GL, Gaw S. Leaching and extraction of additives from plastic pollution to inform environmental risk: A multidisciplinary review of analytical approaches. J. Hazard. Mater. 2021; 414: 125571
    Suche in Google Scholar
  • 32 Nasa P. A review on pharmaceutical packaging material. World J. Pharm. Res. 2014; 3 (05) 344-368
    Suche in Google Scholar
  • 33 EDITION T. ENCYCLOPEDIA OF PACKAGING TECHNOLOGY. 2009
  • 34 Sheldon RA. Green and sustainable manufacture of chemicals from biomass: state of the art. Green Chem. 2014; 16 (03) 950-963
    Suche in Google Scholar
  • 35 Walsh G. Biopharmaceutical benchmarks 2018. Nat. Biotechnol. 2018; 36 (12) 1136-1145
    Suche in Google Scholar
  • 36 Rajagopal D, Zilberman D. Environmental, economic and policy aspects of biofuels. Found. Trends Microecon. 2008; 4 (05) 353-468
    Suche in Google Scholar
  • 37 Kunal CM, Akhilesh D, Kumar BS. Recent trends in pharmaceutical packaging: A review. Int. J. Pharm. Chem. Sci. 2012; 1 (03) 1282-1292
    Suche in Google Scholar
  • 38 Rejeb A, Rejeb K, Appolloni A, Jagtap S, Iranmanesh M, Alghamdi S. et al. Unleashing the power of internet of things and blockchain: A comprehensive analysis and future directions. Internet Things Cyber-Phys. Syst. 2024; 4: 1-18
    Suche in Google Scholar
  • 39 Zemanová Š, Druláková R. Mainstreaming global sustainable development goals through the un global compact: the case of visegrad countries. J. Risk Financ. Manage. 2020; 13 (03) 41
    Suche in Google Scholar
  • 40 Milanesi M, Runfola A, Guercini S. Pharmaceutical industry riding the wave of sustainability: Review and opportunities for future research. J. Cleaner Prod. 2020; 261: 121204
    Suche in Google Scholar
  • 41 Abaku EA, Odimarha AC. Sustainable supply chain management in the medical industry: a theoretical and practical examination. Int. Med. Sci. Res. J. 2024; 4 (03) 319-340
    Suche in Google Scholar
  • 42 Summerton L, Sneddon HF, Jones LC, Clark JH. Green and sustainable medicinal chemistry: methods, tools and strategies for the 21st Century pharmaceutical industry. Royal Society of Chemistry; 2016
    Suche in Google Scholar
  • 43 Hidalgo DB. Applications of Renewable Energy Sources in Cooling and Heating of Buildings
  • 44 Ashkenas R, Manville B. Harvard Business Review leader's handbook: make an impact, inspire your organization, and get to the next level. Harvard Business Press; 2018
    Suche in Google Scholar
  • 45 Yildiz Çankaya S. The effects of strategic sourcing on supply chain strategies. J. Global Oper. Strategic Sourcing. 2020; 13 (02) 129-148
    Suche in Google Scholar
  • 46 Al-Awamleh H, Alhalalmeh M, Alatyat Z, Saraireh S, Akour I, Alneimat S. et al. The effect of green supply chain on sustainability: Evidence from the pharmaceutical industry. Uncertain Supply Chain Manage. 2022; 10 (04) 1261-1270
    Suche in Google Scholar
  • 47 Sam AG, Song D. ISO 14001 certification and industrial decarbonization: An empirical study. J. Environ. Manage. 2022; 323: 116169
    Suche in Google Scholar
  • 48 Reshmy R, Philip E, Madhavan A, Arun K, Binod P, Pugazhendhi A. et al. Promising eco-friendly biomaterials for future biomedicine: Cleaner production and applications of Nanocellulose. Environ. Technol. Innov. 2021; 24: 101855
    Suche in Google Scholar
  • 49 Ole NC, Omotuyi OY, Herbert EB, Omukoro DE. Environmental laws and enforcement: Prospects and challenges. Environ. Pollut. Public Health 2024; 305-326
    Suche in Google Scholar
  • 50 Wettstein DJ, Boes S. Effectiveness of national pricing policies for patent-protected pharmaceuticals in the OECD: a systematic literature review. Appl. Health Econ. Health Policy 2019; 17: 143-162
    Suche in Google Scholar
  • 51 Hensley P, LaMattina JL. A plan for sustainable funding for US biomedical research. Nat. Rev. Drug Discovery 2015; 14 (02) 147-149
    Suche in Google Scholar
  • 52 Spraul K, Thaler J. Partnering for good? An analysis of how to achieve sustainability-related outcomes in public–private partnerships. Bus. Res. 2020; 13 (02) 485-511
    Suche in Google Scholar
  • 53 Green healthcare system: Main features in supporting sustainability of healthcare system—A review. In Green Buildings and Renewable Energy: Med Green Forum 2019-Part of World Renewable Energy Congress and Network. Fadda J. Ed Springer; 2020
    Suche in Google Scholar
  • 54 Ranjbari M, Esfandabadi ZS, Shevchenko T, Chassagnon-Haned N, Peng W, Tabatabaei M. et al. Mapping healthcare waste management research: Past evolution, current challenges, and future perspectives towards a circular economy transition. J. Hazard. Mater. 2022; 422: 126724
    Suche in Google Scholar
  • 55 Martín-Matute B, Meier MA, Métro T.-X, Koenig SG, Sneddon HF, Sudarsanam P. et al. Sustainable Chemistry and Engineering in Pharma. ACS Publications; 2021. pp 13395-13398
    Suche in Google Scholar
  • 56 Kumar M, Sridharan S, Sawarkar AD, Shakeel A, Anerao P, Mannina G. et al. Current research trends on emerging contaminants pharmaceutical and personal care products (PPCPs): A comprehensive review. Sci. Total Environ. 2023; 859: 160031
    Suche in Google Scholar
  • 57 Hellweg S, Milà i Canals L. Emerging approaches, challenges and opportunities in life cycle assessment. Science 2014; 344 (6188) 1109-1113
    Suche in Google Scholar
  • 58 Suleman A, Kondiah PP, Mabrouk M, Choonara YE. The application of 3D-printing and nanotechnology for the targeted treatment of osteosarcoma. Front. Mater. 2021; 8: 668834
    Suche in Google Scholar