Facile Synthesis of 2- and 3-Substituted Indoles Using a Catalytic Amount of Pd/C and 1-Octene System

Xu Dong; Ryosuke Matsubara; Masahiko Hayashi

doi:10.1055/a-2464-6964

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Synthesis
DOI: 10.1055/a-2464-6964

paper

Facile Synthesis of 2- and 3-Substituted Indoles Using a Catalytic Amount of Pd/C and 1-Octene System

Xu Dong

¹Chemistry, Kobe University, Kobe, Japan

,

Ryosuke Matsubara

¹Chemistry, Kobe University, Kobe, Japan

,

Masahiko Hayashi

²Department of Chemistry, Graduate School of Science, Kobe University, Kobe, Japan

› Author AffiliationsSupported by: the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan

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Herein, novel and efficient synthesis of 3- and 2-substituted indoles starting from 2-(2-nitro-1-phenylethyl or 2-nitro-1-alkyl)cyclohexanones and 1,4-diketones, respectively using a catalytic amount of Pd/C and 1-octene system is reported.

Publication History

Received: 09 October 2024

Accepted after revision: 08 November 2024

Accepted Manuscript online:
08 November 2024

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