Hamostaseologie 2025; 45(01): 063-069
DOI: 10.1055/a-2491-3668
Review Article

Combining Diagnostics and Research in an Academic Laboratory

Grit Waitz
1   Institut für Transfusionsmedizin, Universitätsmedizin Rostock, Rostock, Germany
,
Stefan Handtke
2   Institut für Transfusionsmedizin, Universitätsmedizin Greifswald, Greifswald, Germany
,
Carlo Zaninetti
2   Institut für Transfusionsmedizin, Universitätsmedizin Greifswald, Greifswald, Germany
,
Linda Schönborn
2   Institut für Transfusionsmedizin, Universitätsmedizin Greifswald, Greifswald, Germany
,
Thomas Thiele
1   Institut für Transfusionsmedizin, Universitätsmedizin Rostock, Rostock, Germany
2   Institut für Transfusionsmedizin, Universitätsmedizin Greifswald, Greifswald, Germany
› Institutsangaben

Abstract

Combining diagnostics and research in academic laboratories faces challenges and bears great opportunities. In this short review, we describe the objectives of diagnostic and research laboratories dealing with thrombosis and hemostasis questions. We give an overview of specific goals for diagnostic and research laboratories and explain the synergies and tasks which need to be managed in an interdisciplinary team.



Publikationsverlauf

Eingereicht: 21. Oktober 2024

Angenommen: 27. November 2024

Artikel online veröffentlicht:
19. Februar 2025

© 2025. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 
  • References

  • 1 Lämmle B. Clinical problem solving and using new paths in the laboratory: learning from case studies. Hamostaseologie 2020; 40 (04) 414-419
  • 2 Oldenburg J, Klamroth R, Langer F. et al. Diagnosis and management of vaccine-related thrombosis following AstraZeneca COVID-19 vaccination: guidance statement from the GTH. Hamostaseologie 2021; 41 (03) 184-189
  • 3 Hu T, Chitnis N, Monos D, Dinh A. Next-generation sequencing technologies: an overview. Hum Immunol 2021; 82 (11) 801-811
  • 4 Kumar KR, Cowley MJ, Davis RL. Next-generation sequencing and emerging technologies. Semin Thromb Hemost 2019; 45 (07) 661-673
  • 5 Moffat KA, Kiencke V, Blanco AN. et al. International Society on Thrombosis and Haemostasis core curriculum project: core competencies in laboratory thrombosis and hemostasis. J Thromb Haemost 2019; 17 (11) 1848-1859
  • 6 Bradke F, Maartens A, Teichmann SA. Key attributes of successful research institutes. PLoS Biol 2023; 21 (09) e3002267
  • 7 Liston A, Lesage S. Starting your independent research laboratory. Stroke 2021; 52 (08) e520-e522
  • 8 Swartz TH, Palermo AS, Masur SK, Aberg JA. The science and value of diversity: closing the gaps in our understanding of inclusion and diversity. J Infect Dis 2019; 220 (220, Suppl 2): S33-S41
  • 9 Science benefits from diversity. Nature 2018; 558 (7708): 5
  • 10 Mackway-Jones K. Seeking funding for research. Emerg Med J 2003; 20 (04) 359-361
  • 11 Schneiter S, Colucci G, Sulzer I, Barizzi G, Lämmle B, Alberio L. Variability of anti-PF4/heparin antibody results obtained by the rapid testing system ID-H/PF4-PaGIA. J Thromb Haemost 2009; 7 (10) 1649-1655
  • 12 Dignos PN, Khan A, Gardiner-Davis M. et al. Hidden and understaffed: exploring Canadian medical laboratory technologists' pandemic stressors and lessons learned. Healthcare (Basel) 2023; 11 (20) 2736
  • 13 Sexton JB, Adair KC, Proulx J. et al. Emotional exhaustion among US health care workers before and during the COVID-19 pandemic, 2019-2021. JAMA Netw Open 2022; 5 (09) e2232748
  • 14 Rabbani N, Kim GYE, Suarez CJ, Chen JH. Applications of machine learning in routine laboratory medicine: current state and future directions. Clin Biochem 2022; 103: 1-7
  • 15 Link KG, Stobb MT, Monroe DM. et al. Computationally driven discovery in coagulation. Arterioscler Thromb Vasc Biol 2021; 41 (01) 79-86
  • 16 Chiasakul T, Lam BD, McNichol M. et al. Artificial intelligence in the prediction of venous thromboembolism: a systematic review and pooled analysis. Eur J Haematol 2023; 111 (06) 951-962
  • 17 Greinacher A, Pecci A, Kunishima S. et al. Diagnosis of inherited platelet disorders on a blood smear: a tool to facilitate worldwide diagnosis of platelet disorders. J Thromb Haemost 2017; 15 (07) 1511-1521
  • 18 Palma-Barqueros V, Revilla N, Sánchez A. et al. Inherited platelet disorders: an updated overview. Int J Mol Sci 2021; 22 (09) 4521
  • 19 Zaninetti C, Leinøe E, Lozano ML. et al. Validation of immunofluorescence analysis of blood smears in patients with inherited platelet disorders. J Thromb Haemost 2023; 21 (04) 1010-1019
  • 20 Brøns N, Zaninetti C, Ostrowski SR. et al. A novel homozygous GFI1B variant in 2 sisters with thrombocytopenia and severe bleeding tendency. Platelets 2021; 32 (05) 701-704
  • 21 Palma-Barqueros V, Bastida JM, López Andreo MJ. et al; Grupo Español de Alteraciones Plaquetarias Congénitas (GEAPC), Spanish Society of Thrombosis and Haemostasis (SETH). Platelet transcriptome analysis in patients with germline RUNX1 mutations. J Thromb Haemost 2023; 21 (05) 1352-1365
  • 22 Palma-Barqueros V, Revilla N, Zaninetti C. et al. Src-related thrombocytopenia: a fine line between a megakaryocyte dysfunction and an immune-mediated disease. Blood Adv 2022; 6 (17) 5244-5255
  • 23 Zaninetti C, Baschin M, Vater L. et al. Platelet expression of the transcription factor ETV6 associates with ETV6-related thrombocytopenia and can be detected by immunofluorescence on the blood film. Br J Haematol 2024; 204 (02) 710-714
  • 24 Zaninetti C, Rivera J, Vater L. et al. Aggregates of nonmuscular myosin IIA in erythrocytes associate with GATA1- and GFI1B-related thrombocytopenia. J Thromb Haemost 2024; 22 (04) 1179-1186
  • 25 Greinacher A, Thiele T, Warkentin TE, Weisser K, Kyrle PA, Eichinger S. Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination. N Engl J Med 2021; 384 (22) 2092-2101
  • 26 Thiele T, Weisser K, Schönborn L. et al. Laboratory confirmed vaccine-induced immune thrombotic thrombocytopenia: retrospective analysis of reported cases after vaccination with ChAdOx-1 nCoV-19 in Germany. Lancet Reg Health Eur 2022; 12: 100270
  • 27 Schönborn L, Esteban O, Wesche J. et al. Anti-PF4 immunothrombosis without proximate heparin or adenovirus vector vaccine exposure. Blood 2023; 142 (26) 2305-2314
  • 28 Greinacher A, Selleng K, Palankar R. et al. Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia. Blood 2021; 138 (22) 2256-2268
  • 29 Wang JJ, Schönborn L, Warkentin TE. et al. Antibody fingerprints linking adenoviral anti-PF4 disorders. N Engl J Med 2024; 390 (19) 1827-1829
  • 30 Lindhoff-Last E, Schönborn L, Zaninetti C, Warkentin TE, Greinacher A. Rescue therapy in chronic prothrombotic autoimmune anti-PF4 disorder. N Engl J Med 2023; 389 (14) 1339-1341