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Synthesis
DOI: 10.1055/a-2492-3240
DOI: 10.1055/a-2492-3240
feature
Synthesis of Isatins via Oxone®/TBAI-Mediated On-Water Oxidation of Indoles
This work was financially supported by the Council of Scientific and Industrial Research, India (CSIR, India) via Project Nos. HCP23 and HCP50. P.K. thanks CSIR for a fellowship. D.B. thanks CSIR-IIIM and CSIR-NCL for fellowships.
Abstract
Isatins and their derivatives are important scaffolds in a wide range of pharmaceuticals, bioactive compounds, and functional materials. Herein we describe a new strategy for the synthesis of isatins from indoles via Oxone®/TBAI-mediated oxidative dearomatization of indoles in water. The strategy works well with a variety of N-protected indoles and azaindoles.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2492-3240.
- Supporting Information
Publication History
Received: 25 September 2024
Accepted after revision: 28 November 2024
Accepted Manuscript online:
28 November 2024
Article published online:
07 January 2025
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