Download PDF
Planta Med
DOI: 10.1055/a-2494-9020
Reviews

Plants with Hair Growth Activity for Alopecia: A Scoping Review on Methodological Aspects

Sharize Betoni Galende 
1   Department of Pharmacy, Laboratory of Pharmaceutical Biology, Palafito, Universidade Estadual de Maringá, Maringá, Brazil
,
Mariana Nascimento de Paula 
1   Department of Pharmacy, Laboratory of Pharmaceutical Biology, Palafito, Universidade Estadual de Maringá, Maringá, Brazil
,
Mariana Millan Fachi 
2   Department of Pharmacy, Universidade Federal do Paraná, Curitiba, Brazil
,
Daniela Cristina de Medeiros Araújo 
3   Course of Pharmacy, Centro Universitário Ingá, Maringá, Brazil
,
Danielly Chierrito 
3   Course of Pharmacy, Centro Universitário Ingá, Maringá, Brazil
,
João Carlos Palazzo de Mello 
1   Department of Pharmacy, Laboratory of Pharmaceutical Biology, Palafito, Universidade Estadual de Maringá, Maringá, Brazil
› Author AffiliationsThe authors would like to thank the Laboratory of Pharmaceutical Biology (Palafito) at Universidade Estadual de Maringá. This work was supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Scholarship Finance Code 001 for S. B.Galende) and CNPq (grant #310 407/2022 – 2 for J. C. P. Mello).
› Further Information
Also available at
    Permissions and Reprints

Abstract

Alopecia is a common dermatological disorder of patchy hair loss with substantial patient burden. Phytotherapeutic compounds are increasingly used as a source of new therapeutic options. This review aimed to synthesize the evidence on plant species in hair growth and the methodological aspects of in vivo experimental models. The systematic scoping review was conducted following the PRISMA checklist, the Joanna Briggs Institute, and in accordance with Cochrane. A systematic search was carried out in the Pubmed, Scopus, Web of Science, and SciELO databases. In vivo experiments that evaluated hair growth activity using natural substances of plant origin were included. Data collection and analysis: a total of 1250 studies were identified, of which 175 were included for qualitative synthesis. Of these, 128 used mice, 37 rats, 10 rabbits, 1 guinea pig, and 1 sheep as animal models. The methodologies mapped were as follows: hair growth analysis, histological analysis, immunohistochemistry, gene expression analysis, Western blot, enzyme-linked immunosorbent assay, and biochemical analysis. Minoxidil and finasteride were the most commonly used positive controls. The studies evaluated plant species (166), algae (11), or isolated substances (31). Overall, 152 plant species and 37 isolated substances were identified. This is the first systematic scoping review on the methodological aspects of in vivo hair growth activity. We created a checklist to be completed by authors to allow data comparison and reproducibility, facilitate data interpretation by readers, and ensure better quality of evidence. This work may become a valuable tool for future research and contribute to significant advances in hair growth studies.

Keywords

hair regrowth - baldness - herbal medicine - biological products - methodology

Supporting Information

    The data underlying this article are available in the article and in its online supplementary material, such as complete search strategies, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) checklist, studies excluded after full reading, and the chemical structures of the isolated substances identified in the studies.

  • Supporting Information


Publication History

Received: 12 August 2024

Accepted after revision: 29 November 2024

Accepted Manuscript online:
02 December 2024

Article published online:
20 January 2025

© 2025. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

  • References

  • 1 Likhitkar M, Shakur AA, Bansal KK, Pande M. Alopecia – Reason and possible treatments. MOJ Drug Des Dev Ther 2018; 2: 198-208
    Search in Google Scholar
  • 2 Phillips TG, Slomiany WP, Allison R. Hair loss: Common causes and treatment. Am Fam Physician 2017; 96: 371-378
    Search in Google Scholar
  • 3 Fricke ACV, Miteva M. Epidemiology and burden of alopecia areata: A systematic review. Clin Cosmet Investig Dermatol 2015; 8: 397-403
    Search in Google Scholar
  • 4 Macbeth AE, Holmes S, Harries M, Chiu WS, Tziotzios C, Lusignan S, Messneger AG, Thompson AR. The associated burden of mental health conditions in alopecia areata: A population-based study in UK primary care. Br J Dermatol 2022; 187: 73-81
    Search in Google Scholar
  • 5 Toussi A, Barton VR, Le ST, Agbai ON, Kiuru M. Psychosocial and psychiatric comorbidities and health-related quality of life in alopecia areata: A systematic review. J Am Acad Dermatol 2021; 85: 162-175
    Search in Google Scholar
  • 6 Okhovat JP, Marks DH, Manatis-Lornell A, Hagigeorges D, Locascio JJ, Senna MM. Association between alopecia areata, anxiety, and depression: A systematic review and meta-analysis. J Am Acad Dermatol 2019; 88: 1040-1050
    Search in Google Scholar
  • 7 Katoulis AC, Christodoulou C, Liakou AI, Kouris A, Korkoliaku P, Kaloudi E, Kanelleas A, Papageorgiou C, Rigopoulos D. Quality of life and psychosocial impact of scarring and non-scarring alopecia in women. J Dtsch Dermatol Ges 2015; 13: 137-141
    Search in Google Scholar
  • 8 Layegh P, Arshadi HR, Shahriari S, Pezeshkpour F, Nahidi Y. A comparative study on the prevalence of depression and suicidal ideation in dermatology patients suffering from psoriasis, acne, alopecia areata and vitiligo. Iran J Dermatology 2010; 13: 106-111
    Search in Google Scholar
  • 9 Vélez-Muñiz RDC, Peralta-Pedrero ML, Jurado-Santa Cruz F, Morales-Sánchez MA. Psychological profile and quality of life of patients with alopecia areata. Ski Appendage Disord 2019; 5: 293-298
    Search in Google Scholar
  • 10 Sinclair RD. Alopecia areata and suicide of children. Med J Aust 2014; 200: 145
    Search in Google Scholar
  • 11 Kotiyal R, Chauhan A, Mishra A, Adhikari L, Semwal D, Semalty A, Semalty M. Alopecia and the herbal drugs: An overview of the current status. Adv Biomed Pharma 2015; 32: 246-254
    Search in Google Scholar
  • 12 Rose PT. Hair restoration surgery: Challenges and solutions. Clin Cosmet Investig Dermatol 2015; 8: 361-370
    Search in Google Scholar
  • 13 Jimenez F, Vogel JE, Avram M. CME Part II. Hair transplantation: Surgical technique. J Am Acad Dermatol 2021; 85: 818-829
    Search in Google Scholar
  • 14 Rinaldi S, Bussa M, Mascaro A. Update on the treatment of androgenetic alopecia. Eur Rev Med Pharmacol Sci 2016; 20: 54-58
    Search in Google Scholar
  • 15 Rogers NE, Avram MR. Medical treatments for male and female pattern hair loss. J Am Acad Dermatol 2008; 59: 547-566
    Search in Google Scholar
  • 16 Tai T, Kochhar A. Physiology and medical treatments for alopecia. Facial Plast Surg Clin North Am 2020; 28: 149-159
    Search in Google Scholar
  • 17 United States Food and Drug Administration. FDA approves first systemic treatment for alopecia areata. Accessed June 12, 2023 at: https://www.fda.gov/news-events/press-announcements/fda-approves-first-systemic-treatment-alopecia-areata
  • 18 King B, Mostaghimi A, Shimomura Y, Zlotogorski A, Choi GS, Blume-Peytavi U, Passeron T, Holzwarth K, Dutronc Y, McCollam J, Yang FE, Stanley S, Wu WS, Sinclair R. Integrated safety analysis of baricitinib in adults with severe alopecia areata from two randomized clinical trials. Br J Dermatol 2023; 188: 218-227
    Search in Google Scholar
  • 19 Bartere SA, Malode LL, Malode LL, Nimbalwar MG, Gulhane CA, Manwar JV, Bakal RL. Exploring the potential of herbal drugs for the treatment of hair loss. GSC Biol Pharm Sci 2021; 16: 212-223
    Search in Google Scholar
  • 20 Tricco AC, Lillie E, Zarin W, OʼBrien KK, Colquhoun H, Levac D, Moher D, Peters MDJ, Horsleu T, Weeks L, Hempel S, Akl EA, Chang C, McGowan J, Stewart L, Hartling L, Aldcrofy A, Wilson MG, Garritty C, Lewin S, Godfrey CM, Macdonald MT, Langlois EV, Soares-Weiser K, Moriarty J, Clifford T, Tunçalp Ö, Straus SE. PRISMA extension for scoping reviews (PRISMA-ScR): Checklist and explanation. Ann Intern Med 2018; 169: 467-473
    Search in Google Scholar
  • 21 Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page M, Welch V. Cochrane Handbook for Systematic Reviews of Interventions Version 6.3. Accessed September 25, 2022 at; https://training.cochrane.org/handbook/current
  • 22 Peters MDJ, Godfrey C, McInerney P, Munn Z, Tricco AC, Khalil H. Chapter 11: Scoping Reviews (2020 Version). In: Aromataris E, Munn Z (eds) JBI Manual for Evidence Synthesis, JBI. Accessed February 22, 2020 at: https://synthesismanual.jbi.global
  • 23 Kumar N, Rungseevijitprapa W, Narkkhong N, Suttajit M. 5α-reductase inhibition and hair growth promotion of some Thai plants traditionally used for hair treatment. J Ethnopharmacol 2012; 139: 765-771
    Search in Google Scholar
  • 24 Hou C, Miao Y, Ji H, Wang S. 6-Gingerol inhibits hair cycle via induction of MMP2 and MMP9 expression. An Acad Bras Ciênc 2017; 89: 2707-271725
    Search in Google Scholar
  • 25 Mustarichie R, Indriyati W, Mukmin A, Ramdhani D. Activity of Angiopteris evecta for baldness treatment. J Chem Pharm Res 2016; 8: 821-830
    Search in Google Scholar
  • 26 Huang CY, Huang CY, Yang CC, Lee TM, Chang JS. Hair growth-promoting effects of Sargassum glaucescens oligosaccharides extracts. J Taiwan Inst Chem Eng 2022; 134: 104307
    Search in Google Scholar
  • 27 Truong VL, Jeong WS. Hair growth-promoting mechanisms of red ginseng extract through stimulating dermal papilla cell proliferation and enhancing skin health. Prev Nutr Food Sci 2021; 26: 275-284
    Search in Google Scholar
  • 28 Shin JY, Shin DJ, Kang HJ, Cho BO, Park JH, Jang SI. Hair loss improvement effect of Chrysanthemum zawadskii, peppermint and Glycyrrhiza glabra herbal mixture in human follicle dermal papilla cell and C57BL/6 mice. Food Sci Technol 2022; 42: 1-7
    Search in Google Scholar
  • 29 Shin SY, Kwon JE, Kim S, Lee YG, Park S, Kang SC. Hair regeneration effects of Lespedeza bicolor extract in vivo and in vitro . Appl Sci 2022; 12: 1-10
    Search in Google Scholar
  • 30 David PP, Santiago CD, Castillo AL, de Guzman GQ. Hair regenerative activities of flavonoid-rich extract of Equisetum hyemale L. (Equisetaceae) in chemically-induced alopecia in Sprague–Dawley rats. J Pharm Pharmacogn Res 2019; 7: 323-330
    Search in Google Scholar
  • 31 Truong VL, Bak MJ, Lee C, Jun M, Jeong WS. Hair regenerative mechanisms of red ginseng oil and its major components in the testosterone-induced delay of anagen entry in C57BL/6 mice. Molecules 2017; 22: 1505
    Search in Google Scholar
  • 32 Li Y, Sheng Y, Liu J, Xu G, Yu W, Cui Q, Lu X, Du P, An L. Hair-growth promoting effect and anti-inflammatory mechanism of Ginkgo biloba polysaccharides. Carbohydr Polym 2022; 278: 1-11
    Search in Google Scholar
  • 33 Pi L, Lee W, Min SH. Hot water extract of oriental melon leaf promotes hair growth and prolongs anagen hair cycle: In vivo and in vitro evaluation. Food Sci Biotechnol 2016; 25: 575-580
    Search in Google Scholar
  • 34 Imtiaz F, Islam M, Saeed H, Saleem B, Asghar M, Zikria S. Impact of Trigonella foenum-graecum leaves extract on mice hair growth. Pakistan J Zool 2017; 49: 1405-1412
    Search in Google Scholar
  • 35 Zhang Y, Chen S, Qu F, Su G, Zhao Y. In vivo and in vitro evaluation of hair growth potential of Cacumen platycladi, and GC-MS analysis of the active constituents of volatile oil. J Ethnopharmacol 2019; 238: 1-6
    Search in Google Scholar
  • 36 Wang Q, Wang Y, Pang S, Zhou J, Cai J, Shang J. Alcohol extract from Vernonia anthelmintica willd (L.) seed counteracts stress-induced murine hair follicle growth inhibition. BMC Complement Altern Med 2019; 19: 1-12
    Search in Google Scholar
  • 37 Adhirajan N, Kumar TR, Shanmugasundaram N, Babu M. In vivo and in vitro evaluation of hair growth potential of Hibiscus rosa-sinensis Linn. J Ethnopharmacol 2003; 88: 235-239
    Search in Google Scholar
  • 38 Yang JC, Kim BA. In vivo and In vitro hair growth promotion effects of extract from Glycine soja Siebold et Zucc. J Appl Biol Chem 2016; 59: 137-143
    Search in Google Scholar
  • 39 Allayie SA, Hemalatha S, Elanchezhiyan C, Manoharan V, Balasubramanian K, Sheikh BA. In vivo evaluation of hair growth potential of fresh leaf extracts of Naringi crenulata . J Clin Exp Dermatol Res 2012; 3: 3-6
    Search in Google Scholar
  • 40 Manosroi A, Ruksiriwanich W, Manosroi W, Abe M, Manosroi J. In vivo hair growth promotion activity of gel containing niosomes loaded with the Oryza sativa bran fraction (OSF3). Adv Sci Lett 2012; 5: 1-7
    Search in Google Scholar
  • 41 Choi JS, Jeon MH, Moon WS, Moon JN, Cheon EJ, Kim JW, Jung SK, Ji YH, Son SW, Kim MR. In vivo hair growth-promoting effect of rice bran extract prepared by supercritical carbon dioxide fluid. Biol Pharm Bull 2014; 37: 44-53
    Search in Google Scholar
  • 42 Seo SR, Kang G, Ha JW, Kim JC. In vivo hair growth-promoting efficacies of herbal extracts and their cubosomal suspensions. J Ind Eng Chem 2013; 19: 1331-1339
    Search in Google Scholar
  • 43 Begum S, Gu LJ, Lee MR, Li Z, Li JJ, Hossain MJ, Wang YB, Sung CK. In vivo hair growth-stimulating effect of medicinal plant extract on BALB/c nude mice. Pharm Biol 2015; 53: 1098-1103
    Search in Google Scholar
  • 44 Upadhyay S, Ghosh AK, Singh V. Inefficiency of ethanolic extract of Glycyrrhiza glabra and Ziziphus mauritiana roots on androgenic alopecia. J Pharm Negat Results 2014; 5: 25-28 Accessed January 26, 2024 at: https://www.pnrjournal.com/index.php/home/article/view/75/76
    Search in Google Scholar
  • 45 Murata K, Noguchi K, Kondo M, Onishi M, Watanabe N, Okamura K, Matsuda H. Inhibitory activities of Puerariae Flos against testosterone 5α-reductase and its hair growth promotion activities. J Nat Med 2012; 66: 158-165
    Search in Google Scholar
  • 46 Zhang B, Zhang RW, Yin XQ, Lao ZZ, Zhang Z, Wu QG, Yu LW, Lai XP, Wan YH, Li G. Inhibitory activities of some traditional Chinese herbs against testosterone 5-α-reductase and effects of Cacumen platycladi on hair re-growth in testosterone-treated mice. J Ethnopharmacol 2016; 177: 1-9
    Search in Google Scholar
  • 47 Zhang T, Cao S, Yuan H, Park S. Alleviation of androgenetic alopecia with aqueous Paeonia lactiflora and Poria cocos extract intake through suppressing the steroid hormone and inflammatory pathway. Pharmaceuticals 2021; 14: 1-20
    Search in Google Scholar
  • 48 Kazemi M, Taghavi MM, Shabanizadeh A, Taghipour Z, Kaeidi A, Shariati-Kohbanani M. Investigation of grape sap on wingless/integrated and β-catenin genes expression with histological factors on the hair follicle in rat. Res Pharm Sci 2020; 15: 350-357
    Search in Google Scholar
  • 49 Sruthi K, Anupama B, Sudeepthi NL, Krishna PG, Kareem A, Habeed M. Investigation of Wrightia tinctoria extract activity on alopecia using in-silico and in-vivo studies. Res J Pharm Technol 2022; 15: 643-649
    Search in Google Scholar
  • 50 Bhinge SD, Jadhav NR, Randive DS, Bhutkar MA, Chavam R, Kumbhar B. Isolation and identification of hair growth potential fraction from active plant extract of Blumea eriantha DC. grown in Western Ghat of India: In silico study. J Ayurveda Integr Med 2022; 13: 100542
    Search in Google Scholar
  • 51 Jung H, Jung DM, Lee SS, Kim EM, Yoon K, Kim KK. Mangifera indica leaf extracts promote hair growth via activation of Wnt signaling pathway in human dermal papilla cells. Animal Cells Syst 2022; 26: 129-136
    Search in Google Scholar
  • 52 Lee J, Im KR, Jung T, Lee M, Yoon KS. Medicinal herbal complex extract with potential for hair growth-promoting activity. J Soc Cosmet Sci Korea 2012; 38: 277-287
    Search in Google Scholar
  • 53 Huang B, Kang B, Lim SS, Zhang XH. Melandrium firmum extract promotes hair growth by modulating 5α-reductase activity and gene expression in C57BL/6 J mice. Ann Dermatol 2019; 31: 502-510
    Search in Google Scholar
  • 54 Pamudji JS, Suciati T, Sukandar EY, Fidriani I. Microemulsion formulation of Aloe vera gel and Apium graveolens ethanol extract for optimizing hair growth promotion. Asian J Pharm Clin Res 2015; 8: 319-323
    Search in Google Scholar
  • 55 Xiao L, Zhang X, Chen Z, Li J, Li B, Li L. Molecular pathways involved in promoting activity of timosaponin BII on hair growth in C57BL/6 mice. Biomed Res Int 2020; 2020: 1-7
    Search in Google Scholar
  • 56 Lao Z, Fan Y, Huo Y, Liao F, Zhang R, Zhang B, Kong Z, Long H, Xie J, Snag C, Fu L, Lin J, Wu Y, Yu L, Li G. Physcion, a novel inhibitor of 5α-reductase that promotes hair growth in vitro and in vivo . Arch Dermatol Res 2022; 314: 41-51
    Search in Google Scholar
  • 57 Gottumukkala VR, Annamalai T, Mukhopadhyay T, Road P. Phytochemical investigation and hair growth studies on the rhizomes of Nardostachys jatamansi DC. Pharmacogn Mag 2020; 7: 146-150
    Search in Google Scholar
  • 58 Jain PK, Das D, Ak S. Alternative herbal drugs used for treating hair disease. Asian J Pharm Clin Res 2016; 9: 110-112
    Search in Google Scholar
  • 59 Her Y, Lee TK, Sim H, Lee JC, Kim DW, Choi SY, Hong JK, Lee JW, Kim JD, Won MH, Kim SS. Pinus thunbergii bark extract rich in flavonoids promotes hair growth in dorsal skin by regulating inflammatory cytokines and increasing growth factors in mice. Mol Med Rep 2022; 25: 1-9
    Search in Google Scholar
  • 60 Kim EJ, Choi JY, Park BC, Lee B. Platycarya strobilacea s. Et z. extract has a high antioxidant capacity and exhibits hair growth-promoting effects in male C57BL/6 mice. Prev Nutr Food Sci 2014; 19: 136-144
    Search in Google Scholar
  • 61 Rose LC, Rusdi NSS, Asari A, Wahid MEA, Suhaimi H. Potential hair growth of crude extract from Hibiscus rosa-sinensis Linn. Arch Pharma Pr 2020; 11: 13-19
    Search in Google Scholar
  • 62 Chandrasekhar J, Ravindran V, Banji D. Potentiality of aqueous leaf extract of Trichosanthes cucumerina Linn. on hair growth promotion in wistar albino rats. Indian J Nat Prod Resour 2012; 3: 14-19
    Search in Google Scholar
  • 63 Sandhya S, Chandrasekhar J, David B, Vinod KR. Potentiality of hair growth promoting activity of aqueous extract of Abrus precatorius Linn. on wistar albino rats. J Nat Remedies 2012; 12: 1-11
    Search in Google Scholar
  • 64 Sukirti U, Vijender S. Potentiality of petroleum ether (60–80)°C extract of Glycyrrhiza glabra on androgenic alopecia. Asian J Pharm Clin Res 2013; 6: 8-11
    Search in Google Scholar
  • 65 Banerjee PS, Sharma M, Nema RK. Preparation, evaluation and hair growth stimulating activity of herbal hair oil. J Chem Pharm Res 2009; 1: 261-267
    Search in Google Scholar
  • 66 Chen SS, Zhang Y, Lu QL, Lin Z, Zhao Y. Preventive effects of cedrol against alopecia in cyclophosphamide-treated mice. Environ Toxicol Pharmacol 2016; 46: 270-276
    Search in Google Scholar
  • 67 Takahashi T, Kamiya T, Yokoo Y. Proanthocyanidins from grape seeds promote proliferation of mouse hair follicle cells in vitro and convert hair cycle in vivo . Acta Derm Venereol 1998; 78: 428-432
    Search in Google Scholar
  • 68 Kamimura A, Takahashi T. Procyanidin B-3, isolated from barley and identified as a hair-growth stimulant, has the potential to counteract inhibitory regulation by TGF-b1. Exp Dermatol 2002; 11: 532-541
    Search in Google Scholar
  • 69 Chung MS, Bae WJ, Choi SW, Lee KW, Jeon HC, Bashraheel F, Jeon SH, Jung JW, Yoon BI, Kwon EB, Oh HA, Hwang SY, Kim SW. An Asian traditional herbal complex containing Houttuynia cordata Thunb, Perilla frutescens var. acuta and green tea stimulates hair growth in mice. BMC Complement Altern Med 2017; 15: 1-11
    Search in Google Scholar
  • 70 Kang JI, Yoo ES, Hyun JW, Koh YS, Lee NH, Ko MH, Ko CS, Kang HK. Promotion effect of apo-9′-fucoxanthinone from Sargassum muticum on hair growth via the activation of Wnt/β-catenin and VEGF-R2. Biol Pharm Bull 2016; 39: 1273-1283
    Search in Google Scholar
  • 71 Kim SC, Kang JI, Kim MK, Hyun JH, Boo HJ, Park DB, Lee YJ, Yoo ES, Kim YH, Kim YH, Kang HK. Promotion effect of norgalanthamine, a component of Crinum asiaticum, on hair growth. Eur J Dermatol 2010; 20: 42-48
    Search in Google Scholar
  • 72 Kang JI, Kim SC, Hyun JH, Kang JH, Park DB, Lee YJ, Yoo ES, Kang HK. Promotion effect of Schisandra nigra on the growth of hair. Eur J Dermatol 2009; 19: 119-125
    Search in Google Scholar
  • 73 Murata K, Noguchi K, Kondo M, Onishi M, Watanabe N, Okamura K, Matsuda H. Promotion of hair growth by Rosmarinus officinalis leaf extract. Phytother Res 2013; 27: 212-217
    Search in Google Scholar
  • 74 Park GH, Park KY, Cho HI, Lee SM, Han JS, Won CH, Chang SE, Lee MW, Choi JH, Moon KC, Shin H, Kang YJ, Lee DH. Red ginseng extract promotes the hair growth in cultured human hair follicles. J Med Food 2015; 18: 354-362
    Search in Google Scholar
  • 75 Maeda T, Yamamoto T, Isikawa Y. Sanguisorba officinalis root extract has fgf-5 inhibitory activity and reduces hair loss by causing prolongation of the anagen period. Nishi Nihon Hifuka 2007; 69: 81-86
    Search in Google Scholar
  • 76 Kamei H, Noguchi K, Matsuda H, Murata K. Screening of Euphorbiaceae plant extracts for anti-5α-reductase. Biol Pharm Bull 2018; 41: 1307-1310
    Search in Google Scholar
  • 77 Bhinge SD, Bhutkar MA, Randive DS, Wadkar GH, Todkar SS, Savali AS, Chittapurkar HR. Screening of hair growth promoting activity of Punica granatum L. (pomegranate) leaves extracts and its potential to exhibit antidandruff and anti-lice effect. Heliyon 2021; 7: 1-10
    Search in Google Scholar
  • 78 Zhu HL, Gao YH, Yang JQ, Li JB, Gao J. Serenoa repens extracts promote hair regeneration and repair of hair loss mouse models by activating TGF-β and mitochondrial signaling pathway. Eur Rev Med Pharmacol Sci 2018; 22: 4000-4008
    Search in Google Scholar
  • 79 Choi M, Choi SJ, Jang S, Choi HI, Kang BM, Hwang ST, Kwon O. Shikimic acid, a mannose bioisostere, promotes hair growth with the induction of anagen hair cycle. Sci Rep 2019; 9: 1-8
    Search in Google Scholar
  • 80 Kim MH, Choi YY, Cho IK, Hong J, Kim SH, Yang WM. Angelica sinensis induces hair regrowth via the inhibition of apoptosis signaling. Am J Chin Med 2014; 42: 1021-1034
    Search in Google Scholar
  • 81 Seiberg M, Liu JC, Babiarz L, Sharlow E, Shapiro S. Soymilk reduces hair growth and hair follicle dimensions. Exp Dermatol 2001; 10: 405-413
    Search in Google Scholar
  • 82 Ishida H, Inaoka Y, Okada M, Fukushima M, Fukazawa H, Tsuji K. Studies of the active substances in herbs used for hair treatment. III. Isolation of hair-regrowth substances from Polygana senega var. latifolia Torr. et Gray. Biol Pharm Bull 1999; 22: 1249-1250
    Search in Google Scholar
  • 83 Inaoka Y, Shakuya A, Fukazawa H, Ishida H, Nukaya H, Tsuji K, Kuroda H, Okada M, Fukushima M, Kosuge T. Studies on active substances in herbs used for hair treatment. I. Effects of herb extracts on hair growth and Isolation of an active substance from Polyporus umbellatus F. Chem Pharm Bull 1994; 42: 530-533
    Search in Google Scholar
  • 84 Zhou Y, Tang G, Li X, Sun W, Liang Y, Gan D, Liu G, Song W, Wang Z. Study on the chemical constituents of nut oil from Prunus mira Koehne and the mechanism of promoting hair growth. J Ethnopharmacol 2020; 258: 1-11
    Search in Google Scholar
  • 85 Luliana S, Rawinda R, Innas SQ. Test activity of hair tonic of ethyl acetate fraction from the ethanol extract of meniran (Phyllanthus niruri L.) as hair grower to male white rat (Rattus norvegicus) wistar strain. Res J Pharm Tech 2019; 12: 999-1002
    Search in Google Scholar
  • 86 Hirata N, Tokunaga M, Naruto S, Iinuma M, Matsuda H. Testosterone 5α-reductase inhibitory active constituents of Piper nigrum leaf. Biol Pharm Bull 2007; 30: 2402-2405
    Search in Google Scholar
  • 87 Chen L, Duan H, Xie F, Gao Z, Wu X, Chen F, Wu W. Tetrahydroxystilbene glucoside effectively prevents apoptosis induced hair loss. Biomed Res Int 2018; 1-11
    Search in Google Scholar
  • 88 Turnip L, Sihotang RA, Turnip KNT, Arico Z. The effect of coffee residue extract on hair growth. IOP Conf Ser Mater Sci Eng 2018; 420: 1-6
    Search in Google Scholar
  • 89 Junkun B, Hong W, Youlu L, Yanzhu L, Tianyu B, Mineshita S, Liman W. The effect of testosterone and fleece-flower root on mouse hair. J Clin Pharmacol Ther 1994; 25: 2-3
    Search in Google Scholar
  • 90 Ramadhani FJ, Bak DH, Kang SH, Park CH, Park SH, Chung BY, Bai HW. The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity. PLoS One 2022; 17: 1-13
    Search in Google Scholar
  • 91 Mustarichie R, Wicaksono IA, Gozali D. Anti-alopecia activity of DADAP (Erythrina variegata L.) leaves ethanol extract. J Pharm Sci Res 2017; 9: 1849-1854
    Search in Google Scholar
  • 92 Park S, Kim K, Ahn S, Kim H. The effects of SM-215 on androgeneticalopecia. Res J Pharm Tech 2018; 11: 1745-1751
    Search in Google Scholar
  • 93 Esfandiari A, Kelly AP. The effects of tea polyphenolic compounds on hair loss among rodents. J Natl Med Assoc 2005; 97: 1165-1169
    Search in Google Scholar
  • 94 Park W, Lee C, Lee B, Chang I. The extract of Thujae occidentalis semen inhibited 5 a-reductase and androchronogenetic alopecia of B6CBAF1/j hybrid mouse. J Dermatol Sci 2003; 31: 91-98
    Search in Google Scholar
  • 95 Rho SS, Park SJ, Hwang SL, Lee MH, Kim CD, Lee IH, Chang SY, Rang MJ. The hair growth promoting effect of Asiasari radix extract and its molecular regulation. J Dermatol Sci 2005; 38: 89-97
    Search in Google Scholar
  • 96 Awe EO, Makinde JM. The hair growth promoting effect of Russelia equisetiformis Schclect&Chan. J Nat Prod 2009; 2: 70-73
    Search in Google Scholar
  • 97 Roh SS, Deok C, Lee MH, Hwang SL, Rang MJ, Yoon YK. The hair growth promoting effect of Sophora flavescens extract and its molecular regulation. J Dermatol Sci 2002; 30: 43-49
    Search in Google Scholar
  • 98 Lee H, Kim NH, Yang H, Bae SK, Heo Y, Choudhary I, Kwon YC, Byun JK, Yim HJ, Noh BS, Heo JD, Kim E, Kang C. The hair growth-promoting effect of Rumex japonicus Houtt. extract. Evid Based Complement Altern Med 2016; 2016: 1-10
    Search in Google Scholar
  • 99 Shin HS, Park SY, Hwang ES, Lee DG, Song HG, Mavlonov GT, Yi TH. The inductive effect of ginsenoside F2 on hair growth by altering the WNT signal pathway in telogen mouse skin. Eur J Pharmacol 2014; 730: 82-89
    Search in Google Scholar
  • 100 Putra IB, Jusuf NK, Sumantri IB. The potency of Hibiscus rosa-sinensis Linn. leaves ethanol extract as hair growth. O A Maced J Med Sci 2020; 8: 89-92
    Search in Google Scholar
  • 101 Kang JI, Kim EJ, Kim MK, Jeon YJ, Kang SM, Koh YS, Yoo ES, Kang HK. The promoting effect of Ishige sinicola on hair growth. Mar Drugs 2013; 11: 1783-1799
    Search in Google Scholar
  • 102 Mustarichie R, Hasanah AN. Anti-alopecia activity of waste cacao (Theobroma cacao L.) peels. Drug Invent Today 2019; 11: 2194-2199
    Search in Google Scholar
  • 103 Zheng JL, Gu LL, Kim KCD. The promotion of hair regrowth by topical application of a Perilla frutescens extract through increased cell viability and antagonism of testosterone and dihydrotestosterone. J Nat Med 2018; 72: 96-105
    Search in Google Scholar
  • 104 Tong T, Kim N, Park T. Topical application of oleuropein induces anagen hair growth in telogen mouse skin. PLoS One 2015; 10: 1-17
    Search in Google Scholar
  • 105 Park H, Zhang N, Ki D. Topical application of Polygonum multiflorum extract induces hair growth of resting hair follicles through upregulating Shh and catenin expression in C57BL/6 mice. J Ethnopharmacol 2011; 135: 369-375
    Search in Google Scholar
  • 106 Kim MH, Choi YY, Lee JE, Kim K, Yang WM. Topical treatment of hair loss with formononetin by modulating apoptosis. Planta Med 2016; 82: 65-69
    Search in Google Scholar
  • 107 Kang JI, Kim MK, Lee JH, Jeon YJ, Hwang EK, Koh YS, Hyun JW, Kwon SY, Yoo ES, Kan HK. Undariopsis peterseniana promotes hair growth by the activation of Wnt/β-catenin and ERK pathways. Mar Drugs 2017; 15: 1-16
    Search in Google Scholar
  • 108 Mustarichie R, Wicaksono IA, Hayati C. Anti-alopecia characteristics of ethanol extract, n-hexane, ethyl acetate and water fractions of Malvaviscus arboreus Cav. Res J Pharm Tech 2018; 11: 5066-5072
    Search in Google Scholar
  • 109 Matsuda H, Yamazaki M, Matsuo K, Asanuma Y, Kubo M. Anti-androgenic activity of Myricae Cortex – isolation of active constituents from bark of Myrica rubra . Biol Pharm Bull 2001; 24: 259-263
    Search in Google Scholar
  • 110 Patel S, Nag MK, Sharma V, Chauhan NS, Dixit VK. A comparative in vivo and in vitro evaluation of hair growth potential of extracts and an isolate from petroleum ether extract of Cuscuta reflexa Roxb. Beni-Suef Univ J Basic Appl Sci 2014; 3: 165-171
    Search in Google Scholar
  • 111 Matsuda H, Yamazaki M, Naruo S, Asanuma Y, Kubo M. Anti-androgenic and hair growth promoting activities of Lygodii spora (spore of Lygodium japonicum) I. Active constituents inhibiting testosterone 5a-reductase. Biol Pharm Bull 2002; 25: 622-626
    Search in Google Scholar
  • 112 Sakib SA, Tareq AM, Islam A, Rakib A, Islam MN, Udiin MA, Rahman M, Seidel V, Emran TB. Anti-inflammatory, thrombolytic and hair-growth promoting activity of the n-hexane fraction of the methanol extract of Leea indica leaves. Plants 2021; 10: 1-14
    Search in Google Scholar
  • 113 Tiwari G, Tiwari R. Assessment of nutraceutical potential of herbs for promoting hair growth: Formulation considerations of herbal hair oil. Open Dermatol J 2022; 15: 78-83
    Search in Google Scholar
  • 114 Shin SH, Bak S, Kim MK. Baicalin, a flavonoid, affects the activity of human dermal papilla cells and promotes anagen induction in mice. Naunyn Schmiedebergs Arch Pharmacol 2014; 388: 583-586
    Search in Google Scholar
  • 115 Xing F, Yi WJ, Miao F, Su MY, Lei TC. Baicalin increases hair follicle development by increasing canonical Wnt/β-catenin signaling and activating dermal papillar cells in mice. Int J Mol Med 2018; 41: 2079-2085
    Search in Google Scholar
  • 116 Kim MH, Kim S, Yang WM. Beneficial effects of astragaloside IV for hair loss via inhibition of Fas/Fas L-mediated apoptotic signaling. PLoS One 2014; 9: 1-7
    Search in Google Scholar
  • 117 Hajhashemi V, Rajabi P, Mardani M. Beneficial effects of pumpkin seed oil as a topical hair growth promoting agent in a mice model. Avicenna J Phytomed 2019; 9: 499-504
    Search in Google Scholar
  • 118 Tanaka S, Saito M, Tabata M. Bioassay of crude drugs for hair growth promoting activity in mice by a new simple method. Planta Med 1980; Suppl: 84-90
    Search in Google Scholar
  • 119 Nanashima N, Horie K. Blackcurrant extract with phytoestrogen activity alleviates hair loss in ovariectomized rats. Molecules 2019; 24: 1-11
    Search in Google Scholar
  • 120 Mustarichie R, Ramdhani D, Iskandar Y. Characteristics and alopecia activity of pakis gajah (Angiopteris evecta (G. Forst) Hoffm.) growing in Galunggung mountainside, West Java. Asian J Pharm Clin Res 2017; 10: 337-340
    Search in Google Scholar
  • 121 Hou IC, Oi Y, Fujita H, Yano Y, Fukami H, Yoshikawa M. A hair growth-promoting effect of Chinese black tea extract in mice. Biosci Biotechnol Biochem 2013; 77: 1606-1607
    Search in Google Scholar
  • 122 Li Z, Li J, Gu L, Begum S, Wang Y, Sun B, Lee M, Sung C. Chrysanthemum zawadskii extract induces hair growth by stimulating the proliferation and differentiation of hair matrix. Int J Mol Med 2014; 34: 130-136
    Search in Google Scholar
  • 123 Begum S, Lee MR, Gu LJ, Hossain J, Kim HK, Sung CK. Comparative hair restorer efficacy of medicinal herb on nude (foxn1 nu) mice. Biomed Res Int 2014; 2014: 1-9
    Search in Google Scholar
  • 124 Park KS, Park DH. Comparison of Saccharina japonica–Undaria pinnatifida mixture and minoxidil on hair growth promoting effect in mice. Arch Plast Surg 2016; 43: 498-505
    Search in Google Scholar
  • 125 Jung YH, Chae CW, Choi GE, Shin HC, Lim JR, Chang HS, Park J, Cho JH, Park MR, Lee HJ, Han HJ. Cyanidin 3-O-arabinoside suppresses DHT-induced dermal papilla cell senescence by modulating p 38-dependent ER-mitochondria contacts. J Biomed Sci 2022; 29: 1-17
    Search in Google Scholar
  • 126 Jang SK, Kim ST, Lee DI, Park JS, Jo BR, Park JY, Heo J, Joo SS. Decoction and fermentation of selected medicinal herbs promote hair regrowth by inducing hair follicle growth in conjunction with Wnts signaling. Evid Based Complement Altern Med 2016; 2016: 1-10
    Search in Google Scholar
  • 127 Purwal L, Gupta SP, Pande MS. Development and evaluation of herbal formulations for hair growth. J Chem 2008; 5: 34-38
    Search in Google Scholar
  • 128 Deepak H, Kumar SK. Development and evaluation of polyherbal antidandruff hair oil. Pharmacogn J 2010; 2: 328-334
    Search in Google Scholar
  • 129 Bak SS, Ahn BN, Kim JA, Shin SH, Kim JC, Kim MK, Sung YK, Kim SK. Ecklonia cava promotes hair growth. Clin Exp Dermatol 2013; 38: 904-910
    Search in Google Scholar
  • 130 Datta K, Singh AT, Mukherjee A, Bhat B, Ramesh B, Burman AC. Eclipta alba extract with potential for hair growth promoting activity. J Ethnopharmacol 2009; 124: 450-456
    Search in Google Scholar
  • 131 Lee KH, Choi D, Jeong SI, Kim SJ, Lee CH, Seo HS, Jeong HS. Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5. Pharm Biol 2019; 57: 105-111
    Search in Google Scholar
  • 132 Ahn S, Lee JY, Choi SM, Shin Y, Park S. A mixture of tocopherol acetate and L-menthol synergistically promotes hair growth in c57bl/6 mice. Pharmaceutics 2020; 12: 1-14
    Search in Google Scholar
  • 133 Noubarani M, Rostamkhani H, Erfan M, Kamalinejad M, Eskandari MR, Babaeian M, Salamzadeh J. Effect of Adiantum capillus veneris Linn. on an animal model of testosterone-induced hair loss. Iran J Pharm Res 2014; 13: 113-118
    Search in Google Scholar
  • 134 Kim Y, Pi L, Lee W. Effect of Chrysanthemum zawadskii extract on dermal papilla cell proliferation and hair growth. Ann Dermatol 2020; 32: 395-401
    Search in Google Scholar
  • 135 Wen TC, Li YS, Rajamani K, Harn HJ, Lin SZ, Chiou TW. Effect of Cinnamomum osmophloeum Kanehira leaf aqueous extract on dermal papilla cell proliferation and hair growth. Cell Transplant 2018; 27: 256-263
    Search in Google Scholar
  • 136 Roy RK, Thakur M, Dixit VK. Effect of Citrullus colocynthis on hair growth in albino rats. Pharm Biol 2007; 45: 739-744
    Search in Google Scholar
  • 137 Dhanotia R, Chauhan NS, Saraf DK, Vinod K. Effect of Citrullus colocynthis Schrad fruits on testosterone-induced alopecia. Nat Prod Res 2011; 25: 1432-1443
    Search in Google Scholar
  • 138 Pandit S, Chauhan NS, Dixit VK. Effect of Cuscuta reflexa Roxb on androgen-induced alopecia. J Cosmet Dermatol 2008; 7: 199-204
    Search in Google Scholar
  • 139 Kang JI, Kim SC, Kim MK, Boo HJ, Jeon YJ, Koh YS, Yoo ES, Kang SM, Kang HK. Effect of dieckol, a component of Ecklonia cava, on the promotion of hair growth. Int J Mol Sci 2012; 13: 6407-6423
    Search in Google Scholar
  • 140 Huang B, Kang BG, Wang Z, Lim S. Effect of ethanol extract of plant mixture on hair regeneration in human dermal papilla cells and C57BL/6 J mice. J Med Plants Res 2015; 9: 1103-1110
    Search in Google Scholar
  • 141 Upadhyay SM, Upadhyay P, Ghosh AK, Singh V, Dixit VK. Effect of ethanolic extract of Hibiscus rosa sinensis L., flowers on hair growth in female wistar rats. Sch Res Libr 2011; 3: 258-263
    Search in Google Scholar
  • 142 Upadhyay S, Upadhyay P, Vinode R, Dixit VK. Effect of ethanolic fraction of Hibiscus rosa sinensis L., leaves in androgenic alopecia. Egypt Dermatol Online J 2013; 9: 1-7
    Search in Google Scholar
  • 143 Krishanamoorthy J, Ranganathan S, Gokulshankar S, Ranjith M. A novel herbal formulation enhancing protein synthesis specific for hair growth – a Northern blot analysis. J Appl Cosmetol 2003; 175: 167-175
    Search in Google Scholar
  • 144 Itankar PR, Thakre PT, Murkute AV, Tauqeer M. Effect of medicated oil of Martynia annua leaves and fruits on testosterone induced alopecia in mice. Asian J Pharm Clin Res 2013; 6: 49-52
    Search in Google Scholar
  • 145 Jeong GH, Boisvert WA, Xi MZ, Zhang YL, Choi YB, Cho S, Lee S, Choi C, Lee BH. Effect of Miscanthus sinensis var. purpurascens flower extract on proliferation and molecular regulation in human dermal papilla cells and stressed C57BL/6 mice. Chin J Integr Med 2018; 24: 591-599
    Search in Google Scholar
  • 146 Upadhyay S, Dixit VK, Ghosh AK. Effect of petroleum ether and ethanol fractions of seeds of Abrus precatorius on androgenic alopecia. Rev Bras Farmacogn 2012; 22: 359-363
    Search in Google Scholar
  • 147 Akhtar MS, Jabbar MA. Effect of topical application of oils of amla, coconut, sarson and samsol on growth of rabbitʼs hair and sheep wool. J Pak Med Assoc 1981; 31: 246-249
    Search in Google Scholar
  • 148 Barve KH, Ojha N. Effective detoxification of Abrus precatorius Linn. seeds by shodhana. J Ayurveda Integr Med 2013; 4: 82-85
    Search in Google Scholar
  • 149 Shin K, Kim TS, Kyung J, Kim D, Park D, Choi EK, Lee SP, Yang WS, Kang MH, Kim YB. Effectiveness of the combinational treatment of Laminaria japonica and Cistanche tubulosa extracts in hair growth. Lab Anim Res 2015; 31: 24-32
    Search in Google Scholar
  • 150 Lee TK, Kim B, Kim DW, Ahn JH, Sim H, Lee JC, Yang GE, Her Y, Park JH, Kim HS, Sim HS, Lee HS, Won MH. Effects of decursin and Angelica gigas Nakai root extract on hair growth in mouse dorsal skin via regulating inflammatory cytokines. Molecules 2020; 25: 1-14
    Search in Google Scholar
  • 151 Murata K, Takeshita F, Samukawa K, Tani T, Matsuda H. Effects of Ginseng rhizome and ginsenoside Ro on testosterone 5α-reductase and hair re-growth in testosterone-treated mice. Phytother Res 2012; 53: 48-53
    Search in Google Scholar
  • 152 Uchiyama C, Ishida K, Tsutsui T, Naito A, Kurita K, Hanihara H, Serizawa T, Fujiwara M, Ohdera M. Effects of Hura crepitans and its active ingredient, daphne factor F3, on dihydrotestosterone-induced neurotrophin-4 activation and hair retardation. Biol Pharm Bull 2012; 35: 42-47
    Search in Google Scholar
  • 153 Choi JS, Jung SK, Jeon MH, Moon JN, Moon WS, Ji YH, Choi IS, Son SW. Effects of Lycopersicon esculentum extract on hair growth and alopecia prevention. J Cosmet Sci 2013; 64: 429-443
    Search in Google Scholar
  • 154 Tsuji Y, Denda S, Soma T, Raftery L, Momoi T, Hibino T. A potential suppressor of TGF-β delays catagen progression in hair follicles. JID Symp Proc 2003; 8: 65-68
    Search in Google Scholar
  • 155 Park SY, Kim TY, Shin SM, Park IS, Kim KB, Lee JH. Effects of SM-215 on hair growth by hair follicle stimulation. Indian J Sci Technol 2015; 8: 1-8
    Search in Google Scholar
  • 156 Fard SG, Shamsabadi F, Emadi M, Goh YM, Muhammad K, Mohamed S. Ethanolic extract of Eucheuma cottonii promotes in vivo hair growth and wound healing. J Anim Vet Adv 2011; 10: 601-605
    Search in Google Scholar
  • 157 Jain PK, Das D, Jain P. Evaluating hair growth activity of herbal hair oil. Int J Pharm Tech Res 2016; 9: 321-327
    Search in Google Scholar
  • 158 Jain PK, Dass DJ. Evaluating hair growth potential of some traditional herbs. Asian J Pharm Clin Res 2015; 8: 150-152
    Search in Google Scholar
  • 159 Nandeesh R, Kumar BSA, Lakshman K, Khan S, Swamy VBN, Bharathi T, Ganapathy S. Evaluation of hair growth activity of Buxus wallichiana Baill extract in rats. Iran J Basic Med Sci 2009; 11: 236-241
    Search in Google Scholar
  • 160 Singh N, Tailang M, Pathak AK. Evaluation of hair growth activity of Hibiscus rosa-sinensis and Calotropis gigantea leaves on stress induced alopecia. World J Pharm Res 2017; 6: 477-484
    Search in Google Scholar
  • 161 Savali A, Chitapurkar H, Bhinge S. Evaluation of hair growth promoting activity of Musa paradisiaca unripe fruit extract. J Nat Pharm 2011; 2: 120
    Search in Google Scholar
  • 162 Patel S, Sharma V, Chauhan NS, Thakur M, Dixit VK. Evaluation of hair growth promoting activity of Phyllanthus niruri . Avicenna J Phytomed 2015; 5: 512-519
    Search in Google Scholar
  • 163 Alboreadi MA, Al-Najdawi MM, Jarrar QB, Moshawih S. Evaluation of hair growth properties of topical kombucha tea extracts. Adv Tradit Med 2022; 22: 155-161
    Search in Google Scholar
  • 164 Cruz GK, Martins MIM, Antunes FTT, Souza AH, Wiilland EF, Picada JN, Brum LFS. Evaluation of the efficacy and toxicity of oral and topical pumpkin oil on the hair growth of mice. Acta Histochem 2022; 124: 1-7
    Search in Google Scholar
  • 165 Orafidiya LO, Agbani EO, Adelusola KA, Iwalewa EO. A study on the effect of the leaf essential oil of Ocimum gratissimum Linn. on cyclophosphamide-induced hair loss. Int J Aromather 2004; 14: 119-128
    Search in Google Scholar
  • 166 Begum S, Lee MR, Gu LIJ, Hossain J, Sung CK. Exogenous stimulation with Eclipta alba promotes hair matrix keratinocyte proliferation and downregulates TGF-β1 expression in nude mice. Int J Mol Med 2015; 35: 496-502
    Search in Google Scholar
  • 167 Anjum F, Bukhari SA, Shahid M, Bokhari TH, Talpu MMA. Exploration of nutraceutical potential of herbal oil formulated from parasitic plant. Afr J Tradit Complement Altern Med 2014; 11: 78-86
    Search in Google Scholar
  • 168 Park KM, Kim DW, Lee SH. Extract of Allium tuberosum Rottler ex Spreng promoted the hair growth through regulating the expression of IGF-1. Evid Based Complement Altern Med 2015; 2015: 1-11
    Search in Google Scholar
  • 169 Kubo C, Ogawa M, Uehara N, Katakura Y. Fisetin promotes hair growth by augmenting TERT expression. Front Cell Dev Biol 2020; 8: 1-13
    Search in Google Scholar
  • 170 Lee GS, Hong EJ, Gwak KS, Park MJ, Choi KC, Choi IG, Jang JW, Jeung EB. Fitoterapia the essential oils of Chamaecyparis obtusa promote hair growth through the induction of vascular endothelial growth factor gene. Fitoterapia 2010; 81: 17-24
    Search in Google Scholar
  • 171 Park S, Shin W, Ho J. Fructus Panax ginseng extract promotes hair regeneration in C57BL/6 mice. J Ethnopharmacol 2011; 138: 340-344
    Search in Google Scholar
  • 172 Shin HS, Park SY, Hwang ES, Lee DG, Mavlonov GT, Yi TH. Ginsenoside F2 reduces hair loss by controlling apoptosis through the sterol regulatory element-binding protein cleavage activating protein and transforming growth factor-β pathways in a dihydrotestosterone-induced mouse model. Biol Pharm Bull 2014; 37: 755-763
    Search in Google Scholar
  • 173 Li Z, Li JJ, Gu LJ, Zhang DL, Wang YB, Sung CK. Ginsenosides Rb1 and Rd regulate proliferation of mature keratinocytes through induction of p 63 expression in hair follicles. Phytother Res 2013; 27: 1095-1101
    Search in Google Scholar
  • 174 Shin HS, Lee JM, Park SY, Yang JE, Kim JH, Yi TH. Hair growth activity of Crataegus pinnatifida on C57BL/6 mouse model. Phyther Res 2013; 27: 1352-1357
    Search in Google Scholar
  • 175 Lee BM, Park KS, Lee YJ, Choi ES, Park DH. Hair growth effects of Laminaria japonica extract and growth factor mixture on a C57BL/6 mouse model. Biotechnol Bioprocess Eng 2016; 21: 175-182
    Search in Google Scholar
  • 176 Patel S, Sharma V, Chauhan NS, Dixit VK. A study on the extracts of Cuscuta reflexa Roxb. in treatment of cyclophosphamide induced alopecia. DARU J Pharm Sci 2014; 22: 1-8
    Search in Google Scholar
  • 177 Lee CY, Yang CY, Lin CC, Yu MC. Hair growth is promoted by BeauTop via expression of EGF and FGF-7. Mol Med Rep 2018; 17: 8047-8052
    Search in Google Scholar
  • 178 Ahn JH, Park YE, Kim B, Park CW, Sim TH, Lee TK, Lee JC, Park JH, Kim JD, Lee HS, Won MH. Hair growth is promoted in mouse dorsal skin by a mixture of Platycladus orientalis (L.) Franco leaf extract and alpha-terpineol by increasing growth factors and Wnt3/β-catenin. Nat Prod Commun 2020; 15: 1-8
    Search in Google Scholar
  • 179 Wardani D, Abdassah M, Susilawati Y, Subarnas A. Hair growth potential combination of celery (Apium graveolens L.) and mangkokan (Nothopanax scutellarium Merr.) leaf extract on male white rabbits. Int J Curr Med Sci 2016; 6: 188-195
    Search in Google Scholar
  • 180 Jin GR, Zhang YL, Yap J, Boisver WA, Lee BH. Hair growth potential of Salvia plebeia extract and its associated mechanisms. Pharm Biol 2020; 58: 400-409
    Search in Google Scholar
  • 181 Upadhyay S, Ghosh AK, Singh V. Hair growth promotant activity of petroleum ether root extract of Glycyrrhiza glabra L. (Fabaceae) in female rats. Trop J Pharm Res 2012; 11: 753-758
    Search in Google Scholar
  • 182 Kumar N, Chaiyasut C. Hair growth promoting activity of carthamus tinctorius florets extract- loaded nanostructured lipid carriers. Int J Pharm Pharm Sci 2015; 7: 252-257
    Search in Google Scholar
  • 183 Zhang Y, Han L, Chen SS, Guan J, Qu FZ, Zhao YQ. Hair growth promoting activity of cedrol isolated from the leaves of Platycladus orientalis . Biomed Pharmacother 2016; 83: 641-647
    Search in Google Scholar
  • 184 Rambwawasvika H, Dzomba P, Gwatidzo L. Hair growth promoting effect of Dicerocaryum senecioides phytochemicals. Int J Med Chem 2019; 2019: 1-12
    Search in Google Scholar
  • 185 In J, Al-Reza SM, Chul S. Hair growth promoting effect of Zizyphus jujuba essential oil. Food Chem Toxicol 2010; 48: 1350-1354
    Search in Google Scholar
  • 186 Li Y, Han M, Lin P, He Y, Yu J, Zhao R. Hair growth promotion activity and its mechanism of Polygonum multiflorum . Evid Based Complement Altern Med 2015; 2015: 1-10
    Search in Google Scholar
  • 187 Park SO, Park BS, Noh GY. Action mechanism of natural plant extracts for hair loss prevention and hair growth promotion in C57BL/6 Mice. Int J Pharmacol 2015; 11: 588-595
    Search in Google Scholar
  • 188 Park HJ, Jin GR, Jung JH, Hwang SB, Lee SH, Lee BH. Hair growth promotion effect of nelumbinis semen extract with high antioxidant activity. Evid Based Complement Altern Med 2021; 2021: 1-11
    Search in Google Scholar
  • 189 Kawano M, Han J, Kchouk ME, Isoda H. Hair growth regulation by the extract of aromatic plant Erica multiflora . J Nat Med 2009; 63: 335-339
    Search in Google Scholar
  • 190 Mustarichie R, Wicaksono IA. Hair growth stimulants activity from Sterculia urceolata JE Smith ethanol extract. Res J Pharm Tech 2019; 12: 4111-4116
    Search in Google Scholar
  • 191 Saumendu DR, Raj KP, Suvakanta D, Jashabir C, Biswajit B. Hair growth stimulating effect and phytochemical evaluation of hydro-alcoholic extract of Glycyrrhiza glabra . Glob J Res Med Plants Indig Med 2014; 3: 40-47
    Search in Google Scholar
  • 192 Zhang N, Park DK, Park H. Hair growth-promoting activity of hot water extract of Thuja orientalis . BMC Complement Altern Med 2013; 13: 1-11
    Search in Google Scholar
  • 193 Park PJ, Moon BS, Lee SH, Kim SN, Kim AR, Kim HJ, Park WS, Choi KY, Cho EG, Lee TR. Hair growth-promoting effect of aconiti ciliare tuber extract mediated by the activation of Wnt/β-catenin signaling. Life Sci 2012; 91: 935-943
    Search in Google Scholar
  • 194 Junlatat J, Sripanidkulchai B. Hair growth-promoting effect of carthamus tinctorius floret extract. Phyther Res 2014; 28: 1030-1036
    Search in Google Scholar
  • 195 Boisvert WA, Yu M, Choi Y, Jeong GH, Zhang YL, Cho S, Choi C, Lee S, Lee BH. Hair growth-promoting effect of Geranium sibiricum extract in human dermal papilla cells and C57BL/6 mice. BMC Complement Altern Med 2017; 17: 1-9
    Search in Google Scholar
  • 196 Zhang Y, Ni C, Huang Y, Tang Y, Yang K, Shi X, Zhang Y, Li Z, Wang J, Zhu Y, Li H, Ma Y, Lin J, Wang J, Liu Q, Wu W. Hair growth-promoting effect of resveratrol in mice, human hair follicles and dermal papilla cells. Clin Cosmet Investig Dermatol 2021; 14: 1805-1814
    Search in Google Scholar
  • 197 Wang J, Shen H, Chen T, Ma L. Hair growth-promoting effects of camellia seed cake extract in human dermal papilla cells and C57BL/6 mice. J Cosmet Dermatol 2022; 21: 5018-5025
    Search in Google Scholar
  • 198 Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Galnville J, Grimshaw JM, Hróbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. PLoS Med 2021; 18: e1003583
    Search in Google Scholar
  • 199 Cho EC, Kim K. A comprehensive review of biochemical factors in herbs and their constituent compounds in experimental studies on alopecia. J Ethnopharmacol 2020; 258: 1-19
    Search in Google Scholar
  • 200 Rivera D, Allkin R, Obón C, Alcaraz F, Verpoorte R, Heirich M. What is in a name? The need for accurate scientific nomenclature for plants. J Ethnopharmacol 2014; 152: 393-402
    Search in Google Scholar
  • 201 Jain PK, Das D, Das C. Prospect of herbs as hair growth potential. Innovare J Med Sci 2017; 5: 25-33
    Search in Google Scholar
  • 202 Tenore GC, Caruso D, Buonomo G, DʼAvino M, Santamaria R, Irace C, Piccolo M, Maisto M, Novellino E. Annurca apple nutraceutical formulation enhances keratin expression in a human model of skin and promotes hair growth and tropism in a randomized clinical trial. J Med Food 2018; 21: 90-103
    Search in Google Scholar
  • 203 Kwon OS, Han JH, Yoo HG, Chung JH, Cho KH, Eun HC, Kim KH. Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG). Phytomedicine 2007; 14: 551-555
    Search in Google Scholar
  • 204 Harada N, Okajima K, Arai M, Kurihara H, Nakagata N. Administration of capsaicin and isoflavone promotes hair growth by increasing insulin-like growth factor-I production in mice and in humans with alopecia. Growth Horm IGF Res 2007; 17: 408-415
    Search in Google Scholar
  • 205 Herman A, Herman AP. Mechanism of action of herbs and their active constituents used in hair loss treatment. Fitoterapia 2016; 114: 18-25
    Search in Google Scholar
  • 206 Everts HB, Silva KA, Montgomery S, Suo L, Menser M, Valet AS, King LE, Ong DE, Sunderberg JP. Retinoid metabolism is altered in human and mouse cicatricial alopecia. J Invest Dermatol 2013; 133: 325-333
    Search in Google Scholar
  • 207 Müller-Röver S, Foitzik K, Paus R, Handjiski B, van der Veen C, Eichmüller S, McKay IA, Stenn KS. A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol 2001; 117: 3-15
    Search in Google Scholar
  • 208 Slominski A, Paus R. Melanogenesis is coupled to murine anagen: Toward new concepts for the role of melanocytes and the regulation of melanogenesis in hair growth. J Invert Derm 1993; 101: 90S-97S
    Search in Google Scholar
  • 209 Paus R, Foitzik K. In search of the ʼhair cycle clockʼ: A guided tour. Differentiation 2004; 72: 489-511
    Search in Google Scholar
  • 210 Garza LA, Liu Y, Yang Z, Alagesan B, Lawson JA, Norberg SM, Loy DE, Zhao T, Blatt HB, Stanton DC, Carrasco L, Ahluwalia G, Fischer SM, Fitzgerald GA, Cotsarelis G. Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. Sci Transl Med 2012; 4: 1-21
    Search in Google Scholar
  • 211 Yang K, Tang Y, Ma Y, Liu Q, Huang Y, Zhang Y, Shi X, Zhang L, Zhang Y, Wang J, Zhu Y, Liu W, Tan Y, Lin J, Wu W. Hair growth promoting effects of 650 nm red light stimulation on human hair follicles and study of its mechanisms via RNA sequencing transcriptome analysis. Ann Dermatol 2021; 33: 553-561
    Search in Google Scholar
  • 212 Martinez-Jacobo L, Villarreal-Villarreal CD, Ortiz-López R, Ocampo-Candiani J, Rojas-Martínez A. Genetic and molecular aspects of androgenetic alopecia. Indian J Dermatol Venereol Leprol 2018; 84: 263-268
    Search in Google Scholar
  • 213 Herman A, Herman AP. Topically used herbal products for the treatment of hair loss: Preclinical and clinical studies. Arch Dermatol Res 2017; 309: 595-610
    Search in Google Scholar
  • 214 Lonni AASG, Dahmer D, da Costa IAP, DiCiaula MC, Ritter MR, Bruschi ML, Guimarães FB, Bento AC, Rohling JH, Leite-Mello EVS, Natali MRM, Baesso ML, Mello JCP. Evaluation of a multiple microemulsion from Trichilia catigua extract and the percutaneous penetration through skin by Phase-Resolved photoacoustic spectroscopy. Spectrochim Acta A Mol Biomol Spectrosc 2022; 275: 1-11
    Search in Google Scholar