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CC BY-NC-ND 4.0 · J Neurol Surg Rep 2025; 86(01): e1-e3
DOI: 10.1055/a-2496-5240
Case Report

HPV-associated Sinonasal Squamous Cell Carcinoma

Rex H. Lee 
1   Department of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, California, United States
,
Annemieke van Zante
2   Department of Pathology, University of California San Francisco, San Francisco, California, United States
,
Ezequiel Goldschmidt
3   Department of Neurological Surgery, University of California San Francisco, San Francisco, California, United States
,
Ivan H. El-Sayed
1   Department of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, California, United States
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Abstract

Human papillomavirus (HPV)-associated sinonasal squamous cell carcinoma (SNSCC) (HPV+ SNSCC) is a recently recognized entity that accounts for up to one-third of SNSCC. Although at present these cancers are not routinely tested for HPV, the incidence is increasing and HPV+ SNSCC is associated with superior survival outcomes compared with HPV− SNSCC. Here, we present the case of a patient with HPV+ SNSCC treated with endoscopic resection followed by postoperative radiation and review the literature summarizing epidemiology and management of this disease, with emphasis on the importance of HPV testing in SNSCC.

Keywords

human papillomavirus - squamous cell carcinoma - sinonasal - endoscopic


Publication History

Received: 21 October 2024

Accepted: 24 November 2024

Accepted Manuscript online:
05 December 2024

Article published online:
07 January 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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