Klin Padiatr
DOI: 10.1055/a-2501-5991
Original Article

Evaluation of the Cow’s Milk and Hen’s Egg Ladder in Daily Practice: A Parent Perspective

Kuhmilch- und Hühnereileitern im täglichen Leben: Die Perspektive der Eltern
Manuela Bozic
1   Allergy and Clinical Immunology, University Children’s Hospital Basel, Basel, Switzerland
,
Michèle S. Roth
1   Allergy and Clinical Immunology, University Children’s Hospital Basel, Basel, Switzerland
,
Lina Martin
2   Nutrional Health, University Children’s Hospital Basel, Basel, BS, CH, Basel, Switzerland
,
Andrea Werder
2   Nutrional Health, University Children’s Hospital Basel, Basel, BS, CH, Basel, Switzerland
,
Felicitas Bellutti Enders
3   Allergy and Clinical Immunology, University Children’s Hospital Basel, Basel, BS, CH, Basel, Switzerland
› Author Affiliations

Abstract

Aim

Evaluation of the cow’s milk (CM) and hen’s egg (HE) ladder to improve medical care of children with CM and/or HE allergy.

Methods

Through an anonymous retrospective online questionnaire, we investigated parent perspectives regarding the therapy option of a CM and HE ladder in children with CM and/or HE allergy.

Results

Of the 54 families contacted, 29 took part in the study. 19/29 children had already completed the ladders when the survey took place. 19/29 children showed an allergic reaction during the treatment of whom 17 presented skin rashes. 16/29 parents were anxious to rise to the next step in the protocol. 15/29 had difficulties with the implementation of the therapy due to the child refusing the offered food and organizational issues. Medical support as well as the ladder as a therapy option were scored satisfactory.

Conclusion

The participating parents were satisfied with the therapy option and medical care. We identified two main areas for improvement: First, the suggested food for every step should be more diverse, according to the families’ culture background and nutritional needs/demands. Second, to reduce anxiety regarding the therapy, parents must be informed that although allergic reactions are common, they remain mild. Furthermore, we will suggest step changes under medical supervision, especially in families with a slow progression of the food ladder. With these improvements, the duration of therapy could be shortened, thus reducing the risk of an allergic reaction, the need for medical care by an allergist and therefore reducing healthcare costs.

Zusammenfassung

Ziel

Beurteilung der Milch- und Eitreppe zur Verbesserung der medizinischen Versorgung von Kindern mit Kuhmilch (KM)- und/oder Hühnerei (HE)-Allergie.

Methoden

Mithilfe eines anonymen retrospektiven Online-Fragebogens untersuchten wir die Perspektive der Eltern hinsichtlich der Therapieoption einer Milch- und Eitreppe bei Kindern mit KM- und/oder HE-Allergie.

Ergebnisse

Von den 54 kontaktierten Familien haben sich 29 an der Studie beteiligt, wobei 19/29 Kinder die Lebensmitteltreppen bereits abgeschlossen hatten. 19/29 Kinder zeigten während der Therapie eine allergische Reaktion, davon waren 17 kutan. 16/29 Eltern waren besorgt über den Stufenwechsel und 15/29 hatten Schwierigkeiten, die Therapie umzusetzen, da das Kind die angebotenen Nahrungsmittel ablehnte und aus Organisationsgründen. Die medizinische Betreuung sowie die Milch- und/oder Eitreppe als Therapieoption wurden als zufriedenstellend bewertet.

Fazit

Die teilnehmenden Eltern waren mit der Therapiemöglichkeit und der medizinischen Versorgung zufrieden. Wir haben zwei Hauptbereiche für Verbesserungen identifiziert: Die empfohlenen Nahrungsmittel für jeden Schritt sollten vielfältiger sein, entsprechend den kulturellen Bedürfnissen bzw. notwendigen Auslassdiäten der Familien/Patienten. Außerdem sollten die Eltern darüber informiert werden, dass allergische Reaktionen zwar häufig auftreten, aber mild bleiben, um Ängste vor der Therapie zu verringern. Zudem möchten wir vor allem Familien, welche nur langsam mit den Treppen vorankommen, vorschlagen, die Stufenwechsel unter medizinischer Überwachung durchzuführen. Dadurch könnte die Therapiedauer verkürzt werden, um das Risiko einer allergischen Reaktion, die Notwendigkeit einer medizinischen Betreuung durch Allergologen/innen sowie die Gesundheitskosten zu senken.



Publication History

Article published online:
20 January 2025

© 2025. Thieme. All rights reserved.

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  • References

  • 1 Wood RA, Sicherer SH, Vickery BP. et al. The natural history of milk allergy in an observational cohort. J Allergy Clin Immunol 2013; 131: 805-812
  • 2 Sicherer SH, Wood RA, Vickery BP. et al. The natural history of egg allergy in an observational cohort. J Allergy Clin Immunol 2014; 133: 492-499
  • 3 Mousan G, Kamat D. Cow’s Milk Protein Allergy. Clin Pediatr (Phila) 2016; 55: 1054-1063
  • 4 Caffarelli C, Giannetti A, Rossi A. et al. Egg Allergy in Children and Weaning Diet. Nutrients 2022; 14
  • 5 Sakihara T, Otsuji K, Arakaki Y. et al. Early Discontinuation of Cow’s Milk Protein Ingestion Is Associated with the Development of Cow’s Milk Allergy. J Allergy Clin Immunol Pract 2022; 10: 172-179
  • 6 Lachover-Roth I, Cohen-Engler A, Furman Y. et al. Early, continuing exposure to cow’s milk formula and cow’s milk allergy: The COMEET study, a single center, prospective interventional study. Ann Allergy Asthma Immunol 2023; 130: 233-239 e234
  • 7 Valero-Moreno S, Torres-Llanos R, Pérez-Marín M. Impact of Childhood Food Allergy on Quality of Life: A Systematic Review. Applied Sciences. 2024; 14: 10989
  • 8 Greenhawt M. Food allergy quality of life and living with food allergy. Curr Opin Allergy Clin Immunol 2016; 16: 284-290
  • 9 Kim JD, Kim SY, Kwak EJ. et al. Reduction Rate of Specific IgE Level as a Predictor of Persistent Egg Allergy in Children. Allergy Asthma Immunol Res 2019; 11: 498-507
  • 10 Katz Y, Goldberg MR. Natural history of food protein-induced enterocolitis syndrome. Curr Opin Allergy Clin Immunol 2014; 14: 229-239
  • 11 Santos AF, Riggioni C, Agache I. et al EAACI guidelines on the management of IgE-mediated food allergy. Allergy 2024; 10.1111/all.16345
  • 12 Meyer R. Nutritional disorders resulting from food allergy in children. Pediatr Allergy Immunol 2018; 29: 689-704
  • 13 Pajno GB, Fernandez-Rivas M, Arasi S. et al. EAACI Guidelines on allergen immunotherapy: IgE-mediated food allergy. Allergy 2018; 73: 799-815
  • 14 Sabouraud M, Bierme P, Andre-Gomez SA. et al. Oral immunotherapy in food allergies: A practical update for pediatricians. Arch Pediatr 2021; 28: 319-324
  • 15 Pouessel G, Lezmi G. Oral immunotherapy for food allergy: Translation from studies to clinical practice?. World Allergy Organ J 2023; 16: 100747
  • 16 Meyer R, Venter C, Bognanni A. et al. World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow’s Milk Allergy (DRACMA) Guideline update – VII – Milk elimination and reintroduction in the diagnostic process of cow’s milk allergy. World Allergy Organ J 2023; 16: 100785
  • 17 Netting M, Makrides M, Gold M. et al. Heated allergens and induction of tolerance in food allergic children. Nutrients 2013; 5: 2028-2046
  • 18 Venter C, Meyer R, Ebisawa M. et al. Food allergen ladders: A need for standardization. Pediatr Allergy Immunol 2022; 33: e13714
  • 19 Luyt D, Ball H, Makwana N. et al. BSACI guideline for the diagnosis and management of cow’s milk allergy. Clin Exp Allergy 2014; 44: 642-672
  • 20 Athanasopoulou P, Deligianni E, Dean T. et al. Use of baked milk challenges and milk ladders in clinical practice: a worldwide survey of healthcare professionals. Clin Exp Allergy 2017; 47: 430-434
  • 21 Zepeda-Ortega B, Goh A, Xepapadaki P. et al. Strategies and Future Opportunities for the Prevention, Diagnosis, and Management of Cow Milk Allergy. Front Immunol 2021; 12: 608372
  • 22 Vassilopoulou E, McMilin C, Venter C. Mediterranean Milk Ladder: Integrating a Healthy Eating Plan While Reintroducing Cow’s Milk. Children (Basel) 2023; 10
  • 23 Chomyn A, Chan ES, Yeung J. et al. Canadian food ladders for dietary advancement in children with IgE-mediated allergy to milk and/or egg. Allergy Asthma Clin Immunol 2021; 17: 83
  • 24 Chomyn A, Chan ES, Yeung J. et al. Safety and effectiveness of the Canadian food ladders for children with IgE-mediated food allergies to cow’s milk and/or egg. Allergy Asthma Clin Immunol 2023; 19: 94
  • 25 d’Art YM, Forristal L, Byrne AM. et al. Single low-dose exposure to cow’s milk at diagnosis accelerates cow’s milk allergic infants’ progress on a milk ladder programme. Allergy 2022; 77: 2760-2769
  • 26 Philip ES. It seems unbelievable’: Ont. mother warns of allergy therapy risks after daughter’s death. In 2021
  • 27 Chua GT, Chan ES, Yeung J. et al. Patient selection for milk and egg ladders using a food ladder safety checklist. Allergy Asthma Clin Immunol 2022; 18: 51
  • 28 Vazquez-Ortiz M, Infante S. Diagnostic criteria for food protein-induced enterocolitis syndrome: Can we do better?. Ann Allergy Asthma Immunol 2021; 126: 458-459
  • 29 Anagnostou A. Weighing the benefits and risks of oral immunotherapy in clinical practice. Allergy Asthma Proc 2021; 42: 118-123
  • 30 Swanson V, Hannula L. Parenting stress in the early years – a survey of the impact of breastfeeding and social support for women in Finland and the UK. BMC Pregnancy Childbirth 2022; 22: 699