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Synthesis
DOI: 10.1055/a-2502-7704
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Scandium(III)-Catalyzed N-Alkylation of Carbazoles with Alcohols

Yu-Dan Niu
1   School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, China (Ringgold ID: RIN47862)
,
Pei Lv
2   Ningbo institute of Measurement and Testing, Ningbo Institute of Measurement and Testing, Ningbo, China (Ringgold ID: RIN617514)
,
Hao-Lan Hu
1   School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, China (Ringgold ID: RIN47862)
,
Jianghuan Shi
2   Ningbo institute of Measurement and Testing, Ningbo Institute of Measurement and Testing, Ningbo, China (Ringgold ID: RIN617514)
,
Peng Chen 
1   School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, China (Ringgold ID: RIN47862)
,
Yi-Jun Jiang 
3   School of Material Science and Chemical Engineering, Ningbo University, Ningbo, China (Ringgold ID: RIN47862)
› InstitutsangabenGefördert durch: Natural Science Foundation of Ningbo Municipality 202003N4009
Gefördert durch: Natural Science Foundation of Zhejiang Province LY23B040001
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A general and efficient protocol has been developed for the N-alkylation of carbazoles with benzylic alcohols via scandium-catalyzed reaction. This transformation proceeds smoothly under an air atmosphere and features simple reaction conditions and wide substrate scope, which deliver a variety of N-alkylated carbazoles with up to 99% yields and broad functional group compatibilities.



Publikationsverlauf

Eingereicht: 09. Oktober 2024

Angenommen nach Revision: 15. Dezember 2024

Accepted Manuscript online:
15. Dezember 2024

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