Synthesis 2025; 57(07): 1339-1345
DOI: 10.1055/a-2504-3203
paper

Synthesis of Fluorinated 4-Aminopyrimidines via Brønsted Acid Mediated [2+2+2] Cycloaddition of β-Trifluoromethyl-1,3-enynamides with Nitriles

Qin Zeng
a   The Public Experiment Center, University of Shanghai for Science and Technology, 516. Jungong Road, Shanghai 200093, P. R. China
,
Jintong Li
b   Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, P. R. China
,
Yuanjing Xiao
b   Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, P. R. China
› Author Affiliations
We thank the funding support of NSFC (21871093) and STCSM (20ZR1417600).


Abstract

Brønsted acid mediated [2+2+2] cycloaddition of β-CF3-1,3-enynamides with nitriles affording fluorinated 4-aminopyrimidines was developed.

Supporting Information



Publication History

Received: 22 October 2024

Accepted after revision: 17 December 2024

Accepted Manuscript online:
17 December 2024

Article published online:
05 February 2025

© 2025. Thieme. All rights reserved

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany