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Synthesis 2025; 57(07): 1339-1345
DOI: 10.1055/a-2504-3203
DOI: 10.1055/a-2504-3203
paper
Synthesis of Fluorinated 4-Aminopyrimidines via Brønsted Acid Mediated [2+2+2] Cycloaddition of β-Trifluoromethyl-1,3-enynamides with Nitriles
We thank the funding support of NSFC (21871093) and STCSM (20ZR1417600).

Abstract
Brønsted acid mediated [2+2+2] cycloaddition of β-CF3-1,3-enynamides with nitriles affording fluorinated 4-aminopyrimidines was developed.
Key words
β-trifluoromethyl-enynamides - enynamides - pyrimidine - cycloaddition - Brønsted acid - nitrileSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2504-3203.
- Supporting Information
Publication History
Received: 22 October 2024
Accepted after revision: 17 December 2024
Accepted Manuscript online:
17 December 2024
Article published online:
05 February 2025
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