Download PDF
Synthesis
DOI: 10.1055/a-2504-3357
feature

Synthesis of 3,5-disubstituted anilines via sequential Mo-catalyzed deoxygenative benzene formation and Pd-catalyzed amination reactions

Gang Fang
1   Department of Chemistry, College of Chemistry and Chemical Engineering,, Xiamen University, Xiamen, China
,
Yi-Zhe Yu
1   Department of Chemistry, College of Chemistry and Chemical Engineering,, Xiamen University, Xiamen, China
,
Chun-Xiang Zhuo
1   Department of Chemistry, College of Chemistry and Chemical Engineering,, Xiamen University, Xiamen, China
› Author AffiliationsSupported by: the National Natural Science Foundation of China 22171236 and 22371238
Supported by: the National Key R&D Program of China 2021YFA1502500
› Further Information
  PDF Download All articles of this category

The substituted anilines play a pivotal role as structural motifs in agrochemicals, organic polymers, and pharmaceuticals, and great efforts have been dedicated to advancing their synthesis. However, the highly efficient and selective synthesis of meta,meta-disubstituted anilines remains a challenge. Here, we report the synthesis of meta,meta-disubstituted anilines via sequential Mo-catalyzed deoxygenative benzene formation and Pd-catalyzed amination reactions. By employing this method, a wide range of meta,meta-disubstituted anilines were accessed with up to 89% yield from readily accessible ynones, allylic amines, and amines.



Publication History

Received: 04 November 2024

Accepted after revision: 17 December 2024

Accepted Manuscript online:
17 December 2024

© . Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany