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Neuropediatrics
DOI: 10.1055/a-2505-8378
Short Communication

Neonatal Rhabdomyolysis: A Case Report and Review of the Literature

Özlem Ünal Uzun
1   Department of Pediatric Metabolism, Kocaeli University School of Medicine, Izmit, Kocaeli, Turkey
,
Müge Çınar
2   Department of Pediatrics Division of Metabolism, Kocaeli University, Kocaeli, Turkey
,
Meral Bahar İster
1   Department of Pediatric Metabolism, Kocaeli University School of Medicine, Izmit, Kocaeli, Turkey
,
Merve Eşgi
3   Kocaeli University School of Medicine, Izmit, Kocaeli, Turkey
,
Bülent Kara
3   Kocaeli University School of Medicine, Izmit, Kocaeli, Turkey
,
Özge Serçe Pehlevan
4   Division of Child Neurology, Department of Pediatrics, Kocaeli University, Kocaeli Üniversitesi Tıp Fakültesi Çocuk Nörolojisi Bilim Dalı Umuttepe Kampüsü, Kocaeli, Turkey
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Abstract

Rhabdomyolysis is a potentially life-threatening condition in pediatric patients, often triggered by various factors, such as infections, trauma, hereditary metabolic disorders, and certain medications. Elevated creatine kinase levels are commonly observed in newborns and are often attributed to factors such as hypoxia, labor dystocia, and birth trauma. However, rhabdomyolysis in this population is rare and typically associated with hereditary metabolic disorders, medications, or infections. In this report, we describe the case of a neonate diagnosed with very long-chain acyl-CoA dehydrogenase deficiency after markedly elevated creatine kinase levels and rhabdomyolysis were identified during the neonatal period. Additionally, we suggested a guideline for the evaluation of creatine kinase elevation and rhabdomyolysis in neonates.

Keywords

very long-chain acyl-CoA dehydrogenase deficiency - rhabdomyolysis - newborn


Publication History

Received: 17 September 2024

Accepted: 13 December 2024

Accepted Manuscript online:
19 December 2024

Article published online:
09 January 2025

© 2025. Thieme. All rights reserved.

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