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Synthesis
DOI: 10.1055/a-2508-9681
paper

Solvent-Free 2-Chloro-1-Methylpyridinium Iodide (CMPI) mediated Biginelli reaction for the construction of 3,4-dihydropyrimidin-2(1H)-ones/thiones.

Ashish Kumar
1   Chemistry, Babu Banarasi Das University School of Basic Sciences, Lucknow, India (Ringgold ID: RIN301447)
,
Shashi Pandey
2   Department of Chemistry, University of Lucknow Faculty of Science, Lucknow, India (Ringgold ID: RIN123538)
,
Monika Gupta
3   School of Basic Sciences, Department of Chemistry, Babu Banarasi Das University, Lucknow, India (Ringgold ID: RIN301429)
,
Chatrasal Singh Rajput
4   synthesis, Chemistry Innovation Research Center Jubilant Biosys Ltd, Greater Noida, India
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The Biginelli product dihydropyrimidinones (DHPMs) and its derivatives have enormous biological significance. This article described the exploration of 2-chloro-1-methylpyridinium iodide (CMPI) reagent for the development of an environmentally safe, solvent-free protocol to construct the functionalized 3,4-dihydropyrimidin-2(1H)-ones/thiones. The protocol involves the three-component condensation reaction of β-keto ester, aldehyde, and urea or thiourea at elevated temperature. The key advantages of the protocol are its capacity to provide both environmental and economic benefits owing to its solvent-free conditions, short reaction times, simple workup, and good to excellent isolated yield of DHPMs.



Publication History

Received: 03 October 2024

Accepted after revision: 30 December 2024

Accepted Manuscript online:
30 December 2024

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