Facial Plast Surg
DOI: 10.1055/a-2510-6807
FPS Alerts

Exosomes in Facial Plastic Surgery

Manoj T. Abraham
1   Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York
,
John Wilson IV
1   Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York
› Institutsangaben

Abstract

Exosomes have emerged as a promising therapeutic frontier in facial plastic surgery. Preclinical studies have demonstrated their ability to modulate wound healing, skin rejuvenation, hair growth, and nerve regeneration. Early clinical evidence suggests potential benefits in enhancing recovery after laser resurfacing, treating acne scars, and promoting hair growth. Despite their potential, there are currently no exosome products that are FDA-approved for medical use, and they should be considered experimental until receiving regulatory approval and robust clinical validation. As research advances, exosomes may offer valuable tools for facial plastic surgeons to improve patient outcomes and expand regenerative medicine applications in facial aesthetics and reconstruction.



Publikationsverlauf

Artikel online veröffentlicht:
20. Januar 2025

© 2025. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 
  • References

  • 1 Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science 2020; 367 (6478) eaau6977
  • 2 Ku YC, Omer Sulaiman H, Anderson SR, Abtahi AR. The potential role of exosomes in aesthetic plastic surgery: a review of current literature. Plast Reconstr Surg Glob Open 2023; 11 (06) e5051
  • 3 McGraw IT, Wilson EE, Behfar A, Paradise CR, Rohrich RJ, Wyles SP. Evolving role of exosomes in plastic and reconstructive surgery and dermatology. Plast Reconstr Surg Glob Open 2024; 12 (08) e6061
  • 4 Théry C, Witwer KW, Aikawa E. et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles 2018; 7 (01) 1535750
  • 5 Hu S, Li Z, Cores J. et al. Needle-free injection of exosomes derived from human dermal fibroblast spheroids ameliorates skin photoaging. ACS Nano 2019; 13 (10) 11273-11282
  • 6 Liang JX, Liao X, Li SH. et al. Antiaging properties of exosomes from adipose-derived mesenchymal stem cells in photoaged rat skin. BioMed Res Int 2020; 2020: 6406395
  • 7 Li X, Xie X, Lian W. et al. Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model. Exp Mol Med 2018; 50 (04) 1-14
  • 8 Zhao B, Zhang Y, Han S. et al. Exosomes derived from human amniotic epithelial cells accelerate wound healing and inhibit scar formation. J Mol Histol 2017; 48 (02) 121-132
  • 9 Zhou L, Wang H, Jing J, Yu L, Wu X, Lu Z. Regulation of hair follicle development by exosomes derived from dermal papilla cells. Biochem Biophys Res Commun 2018; 500 (02) 325-332
  • 10 Zhang Y, Chopp M, Meng Y. et al. Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury. J Neurosurg 2015; 122 (04) 856-867
  • 11 Dayan S, Gandhi N, Wilson J. et al. Safety and efficacy of human platelet extract in skin recovery after fractional CO2 laser resurfacing of the face: a randomized, controlled, evaluator-blinded pilot study. J Cosmet Dermatol 2023; 22 (09) 2464-2470
  • 12 Kwon HH, Yang SH, Lee J. et al. Combination treatment with human adipose tissue stem cell-derived exosomes and fractional CO2 laser for acne scars: a 12-week prospective, double-blind, randomized, split-face study. Acta Derm Venereol 2020; 100 (18) adv00310
  • 13 Chernoff G. The utilization of human placental mesenchymal stem cell derived exosomes in aging skin: an investigational pilot study. J Surg 2021; 6: 1388
  • 14 Cho BS, Lee J, Won Y. et al. Skin brightening efficacy of exosomes derived from human adipose tissue-derived stem/stromal cells: a prospective, split-face, randomized placebo-controlled study. Cosmetics 2020; 7 (04) 90
  • 15 Huh CH, Kwon SH. Exosome for hair regeneration: from bench to bedside. J Am Acad Dermatol 2019; 81 (04) AB62