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CC BY 4.0 · Endoscopy
DOI: 10.1055/a-2510-8759
Original article

Comparison of Adenoma Detection Rate Between Three-dimensional and Standard Colonoscopy: A Multicenter Randomized Controlled Trial

Wei-Yuan Chang
1   Internal medicine, National Taiwan University Hospital, Taipei, Taiwan (Ringgold ID: RIN38006)
,
Li-Chun Chang
2   Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (Ringgold ID: RIN38006)
,
Hsuan-Ho Lin
3   Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch Hsin-Chu Hospital, Hsinchu, Taiwan (Ringgold ID: RIN63423)
,
Pin-Ya Wei
3   Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch Hsin-Chu Hospital, Hsinchu, Taiwan (Ringgold ID: RIN63423)
,
Hsing-Chien Wu
4   Internal Medicine, National Taiwan University Cancer Center, Taipei, Taiwan (Ringgold ID: RIN587787)
,
Wei-Chih Liao
2   Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (Ringgold ID: RIN38006)
,
Han-Mo Chiu
2   Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (Ringgold ID: RIN38006)
,
Ming-Shiang Wu
2   Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (Ringgold ID: RIN38006)
› InstitutsangabenGefördert durch: MedicalTek Co. Ltd, Taiwan.

Clinical Trial: Registration number (trial ID): NCT05153746, Trial registry: ClinicalTrials.gov (http://www.clinicaltrials.gov/), Type of Study: Randomized, Multi-Center Study
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Background and study aim: Improvement of adenoma detection rate (ADR) effectively reduces the subsequent incidence of colorectal cancer (CRC). Three-dimensional (3D) colonoscopy provided more anatomical details than standard two-dimensional (2D) colonoscopy and improved ADR in a simulation study. We aimed to compare the ADR between 2D and 3D colonoscopy. Patients and methods: In this multicenter randomized controlled trial, subjects aged ≥ 40 years who underwent colonoscopy for screening, surveillance, or symptoms were consecutively enrolled between February 2022 and June 2023 and randomized into 2D or 3D groups with a 1:1 ratio. The primary outcome was ADR. The secondary outcomes included the detection rates of flat adenoma, right-sided adenoma, proximal adenoma, sessile serrated lesion and advanced adenoma. Results: Of the 348 participants recruited, 158 and 160 were allocated to 2D and 3D colonoscopy, respectively. The mucosa inspection time was comparable between the 3D (9.8±2.6 minutes) and 2D (9.4±3.1 minutes) groups (p=.21). The 3D group had significantly higher ADR (53.1% vs. 38.6%, difference (95% confidence interval, CI): 14.5% (3.7-25.4), p=.0094), as well as higher detection rates for flat adenoma (35.0% vs. 21.5%, difference: 13.5% (3.7-23.3), p=.0076), right-sided adenoma (26.3% vs. 15.2%, difference: 11.1% (2.2-19.9), p=.015), proximal adenoma (38.1% vs. 23.4%, difference: 14.7% (4.7-24.7), p=.0045) and adenoma sized 5-9mm (45.0% vs. 31.0%, difference: 14.0% (3.4-24.5), p=.010). However, there was no difference in the detection rate of sessile serrated lesion and advanced adenoma. Conclusions: 3D colonoscopy improved the detection of adenomas without significantly increasing the mucosa inspection time. (ClinicalTrials.gov: NCT05153746)



Publikationsverlauf

Eingereicht: 17. August 2024

Angenommen nach Revision: 29. November 2024

Accepted Manuscript online:
07. Januar 2025

© . The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

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