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CC BY 4.0 · Planta Med 2025; 91(05): 226-237
DOI: 10.1055/a-2512-8928
Reviews

Application of Network Pharmacology in the Treatment of Neurodegenerative Diseases with Traditional Chinese Medicine

Qiang Chen
1   Department of Pharmacy, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
,
Guanghui Chen
2   Department of Pharmacy, Renmin Hospital, Wuhan University, Wuhan, Hubei, China
,
Qianyan Wang
3   Liyuan Cardiovascular Center, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
› InstitutsangabenThe authors are thankful for the support provided by the Natural Science Foundation of Hubei Province (Grant Nos. 2023AFB677, 2024AFB578) and the Intramural Research Program of Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology (Grant Nos. 2023LYYYSZRP0001,2023LYYYGZRP0003). We confirm that the funding sources had no role in the study design, data collection, analysis, interpretation, or manuscript preparation.
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Abstract

In recent years, the incidence of neurodegenerative diseases, including Alzheimerʼs disease, Parkinsonʼs disease, Huntingtonʼs disease, and amyotrophic lateral sclerosis, has exhibited a steadily rising trend, which has posed a major challenge to the global public health. Traditional Chinese medicine, with its multicomponent and multitarget characteristics, offers a promising approach to treating neurodegenerative diseases. However, comprehensively elucidating the complex mechanisms underlying traditional Chinese medicine formulations remains challenging. As an emerging systems biology method, network pharmacology has provided a vital tool for revealing the multitarget mechanisms of traditional Chinese medicine through high-throughput technologies, molecular docking, and network analysis. This paper reviews the advancements in the application of network pharmacology in treating neurodegenerative diseases using traditional Chinese medicine, analyzes the current status of relevant databases and technological methods, discusses the limitations, and proposes future directions to promote the modernization of traditional Chinese medicine and the development of precision medicine.

Keywords

neurodegenerative diseases - traditional Chinese medicine - network pharmacology - therapeutic targets


Publikationsverlauf

Eingereicht: 20. Oktober 2024

Angenommen nach Revision: 06. Januar 2025

Accepted Manuscript online:
08. Januar 2025

Artikel online veröffentlicht:
18. Februar 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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